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European Journal of Nuclear Medicine and Molecular Imaging

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01-02-2008 | Original article

Impact of dual-time-point ¹⁸F-FDG PET imaging and partial volume correction in the assessment of solitary pulmonary nodules

Authors: Khaled Alkhawaldeh, Gonca Bural, Rakesh Kumar, Abass Alavi

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 2/2008

Abstract

Purpose

Our aim was to assess the diagnostic potential of ¹⁸F-FDG PET using partial volume correction and dual-time-point imaging in the assessment of solitary pulmonary nodules.

Methods

We included 265 patients in this retrospective study (171 men; 94 women; age range, 41–92 years). All had pulmonary nodules on CT, and diagnosis was confirmed by biopsy or follow-up CT. All underwent whole body FDG PET, 60 min after FDG injection. Of the 265 patients, 255 underwent second FDG PET for chest 100 min after injection. Maximum SUVs for nodules were calculated from both scans. Partial volume correction for first time SUVs was applied, using coefficient factor. Malignancy was defined using the following criteria: (1) Visual assessment; (2) First time SUV ≥ 2.5; (3) Partial volume corrected first time SUV ≥ 2.5; (4) second time SUV ≥ 2.5; (5) Increase in SUV over time; (6) Increase or no change in SUV; (7) First time SUV ≥ 2.5 and/or increase or no change in SUV.

Results

Biopsy and follow-up revealed 72 malignant lung nodules and 193 benign nodules. Sensitivity, specificity and accuracy for the five criteria were as follows: (1) 97, 58 and 68%; (2) 65, 92 and 85%; (3) 84, 91 and 89%; (4) 90, 80 and 83%; (5) 84, 95 and 92%; (6) 92, 92, and 92%; (7) 95, 90 and 91%, respectively.

Conclusion

Dual-time-point ¹⁸F-FDG PET has potential impact on improving the diagnostic accuracy for malignant lung nodules. Dual-time-point ¹⁸F-FDG PET imaging should be included in the clinical work-up of patients with pulmonary nodule.

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Title: Impact of dual-time-point 18F-FDG PET imaging and partial volume correction in the assessment of solitary pulmonary nodules
Authors: Khaled Alkhawaldeh
Gonca Bural
Rakesh Kumar
Abass Alavi
Publication date: 01-02-2008
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 2/2008
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-007-0584-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Impact of dual-time-point ¹⁸F-FDG PET imaging and partial volume correction in the assessment of solitary pulmonary nodules

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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