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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-06-2003

Epidemiology of Hodgkin's disease and non-Hodgkin's lymphoma

Author: A. J. Swerdlow

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Special Issue 1/2003

Abstract

This review considers in detail the descriptive and aetiological epidemiology of Hodgkin's disease and non-Hodgkin's lymphoma (NHL), with attention to histological subcategories when the literature allows. The aetiology of Hodgkin's disease remains only partially understood. There is evidence that Epstein-Barr virus (EBV) may be involved in the causation of some cases, and clinical immune deficiency is a risk factor for a few, but the evidence is not entirely consistent and other factors may also be important in causing the EBV-associated cases of Hodgkin's disease. The cause of EBV-unassociated cases remains obscure. For NHL, although it has been shown that some cases are related to immune deficiency and chronic antigenic stimulation, and especially to EBV in the context of immune deficiency, the causation of the majority of cases remains unknown. The increasing incidence of NHL, other than that related to AIDS, is also essentially unexplained. Epidemiological investigation of the aetiology of NHL and Hodgkin's disease is making steady progress, however, and there remain leads to be followed that may result in a better understanding and hence prevention.

1. The descriptive epidemiology particularly parallels that of paralytic polio for the nodular sclerosis subtype of Hodgkin's disease; the epidemiology of mixed cellularity tumours more closely resembles that of tuberculosis, with rates greater in people in lower socio-economic conditions and rising with age [11].

2. There is a substantial preponderance of male over female incidence of Hodgkin's disease in children [1], which would accord with the greater general susceptibility of boys than girls to infection [20].

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Title: Epidemiology of Hodgkin's disease and non-Hodgkin's lymphoma
Author: A. J. Swerdlow
Publication date: 01-06-2003
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue Special Issue 1/2003
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-003-1154-9

At a glance: The STEP trials

Springer Medicine

Epidemiology of Hodgkin's disease and non-Hodgkin's lymphoma

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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