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Published in: Skeletal Radiology 6/2020

01-06-2020 | Antibiotic | Review Article

Prosthetic joint infections: diagnosis, management, and complications of the two-stage replacement arthroplasty

Authors: Jack Porrino, Annie Wang, Austin Moats, Hyojeong Mulcahy, Kimia Kani

Published in: Skeletal Radiology | Issue 6/2020

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Abstract

Despite improved strategies to prevent prosthetic joint infection, as the total number of joint replacements increases, so does the absolute number of infections. Radiography serves as the first-line imaging modality for the assessment of a suspected prosthetic joint infection. Additionally, serial radiographs acquired after a surgery to eradicate a prosthetic joint infection are an important clinical tool. Prosthetic joint infections are often treated with a 2-stage replacement arthroplasty utilizing a prosthesis with antibiotic-loaded acrylic cement. While complications are uncommon with this procedure, imaging may demonstrate periprosthetic fractures, as well as spacer migration, joint dislocation, and spacer fracture. We describe the classification of prosthetic joint infections, the clinical and imaging diagnosis, and treatment strategies. Familiarity with the hardware utilized in the management of the prosthetic joint infection, and its potential complications is fundamental to accurate imaging interpretation.
Literature
2.
go back to reference Cyteval C, Bourdon A. Imaging orthopedic implant infections. Diagn Interv Imaging. 2012;93:547–57.CrossRefPubMed Cyteval C, Bourdon A. Imaging orthopedic implant infections. Diagn Interv Imaging. 2012;93:547–57.CrossRefPubMed
3.
go back to reference Heffernan EJ, Alkubaidan FO, White LM, Masri BA, Munk PL. The radiology of antibiotic-impregnated cement. AJR Am J Roentgenol. 2007;189:446–54.CrossRefPubMed Heffernan EJ, Alkubaidan FO, White LM, Masri BA, Munk PL. The radiology of antibiotic-impregnated cement. AJR Am J Roentgenol. 2007;189:446–54.CrossRefPubMed
4.
go back to reference Otto-Lambertz C, Yagdiran A, Wallscheid F, Eysel P, Jung N. Periprosthetic infection in joint replacement. Dtsch Arztebl Int. 2017;114:347–53.PubMedPubMedCentral Otto-Lambertz C, Yagdiran A, Wallscheid F, Eysel P, Jung N. Periprosthetic infection in joint replacement. Dtsch Arztebl Int. 2017;114:347–53.PubMedPubMedCentral
6.
go back to reference Gee R, Munk PL, Keogh C, Nicolaou S, Masri B, Marchinkow LO, et al. Radiography of the PROSTALAC (prosthesis with antibiotic-loaded acrylic cement) orthopedic implant. AJR Am J Roentgenol. 2003;180:1701–6.CrossRefPubMed Gee R, Munk PL, Keogh C, Nicolaou S, Masri B, Marchinkow LO, et al. Radiography of the PROSTALAC (prosthesis with antibiotic-loaded acrylic cement) orthopedic implant. AJR Am J Roentgenol. 2003;180:1701–6.CrossRefPubMed
7.
go back to reference Saeed K. Diagnostics in prosthetic joint infections. J Antimicrob Chemother. 2014;69(Suppl 1):i11–9.CrossRefPubMed Saeed K. Diagnostics in prosthetic joint infections. J Antimicrob Chemother. 2014;69(Suppl 1):i11–9.CrossRefPubMed
8.
go back to reference Springer BD. The diagnosis of periprosthetic joint infection. J Arthroplast. 2015;30:908–11.CrossRef Springer BD. The diagnosis of periprosthetic joint infection. J Arthroplast. 2015;30:908–11.CrossRef
9.
go back to reference Diaz-Ledezma C, Espinosa-Mendoza R, Gallo J, Glaudemans A, Gómez-García F, Goodman S, et al. General assembly, diagnosis, imaging: proceedings of international consensus on orthopedic infections. J Arthroplast. 2019;34:S215–23.CrossRef Diaz-Ledezma C, Espinosa-Mendoza R, Gallo J, Glaudemans A, Gómez-García F, Goodman S, et al. General assembly, diagnosis, imaging: proceedings of international consensus on orthopedic infections. J Arthroplast. 2019;34:S215–23.CrossRef
10.
go back to reference Coventry MB. Treatment of infections occurring in total hip surgery. Orthop Clin North Am. 1975;6:991–1003.PubMed Coventry MB. Treatment of infections occurring in total hip surgery. Orthop Clin North Am. 1975;6:991–1003.PubMed
11.
go back to reference Fitzgerald RH, Nolan DR, Ilstrup DM, Van Scoy RE, Washington JA, Coventry MB. Deep wound sepsis following total hip arthroplasty. J Bone Joint Surg Am. 1977;59:847–55.CrossRefPubMed Fitzgerald RH, Nolan DR, Ilstrup DM, Van Scoy RE, Washington JA, Coventry MB. Deep wound sepsis following total hip arthroplasty. J Bone Joint Surg Am. 1977;59:847–55.CrossRefPubMed
12.
go back to reference Tsukayama DT, Estrada R, Gustilo RB. Infection after total hip arthroplasty. A study of the treatment of one hundred and six infections. J Bone Joint Surg Am. 1996;78:512–23.CrossRefPubMed Tsukayama DT, Estrada R, Gustilo RB. Infection after total hip arthroplasty. A study of the treatment of one hundred and six infections. J Bone Joint Surg Am. 1996;78:512–23.CrossRefPubMed
13.
14.
go back to reference Pellegrini A, Legnani C, Meani E. A new perspective on current prosthetic joint infection classifications: introducing topography as a key factor affecting treatment strategy. Arch Orthop Trauma Surg. 2019;139:317–22.CrossRefPubMed Pellegrini A, Legnani C, Meani E. A new perspective on current prosthetic joint infection classifications: introducing topography as a key factor affecting treatment strategy. Arch Orthop Trauma Surg. 2019;139:317–22.CrossRefPubMed
15.
go back to reference Giulieri SG, Graber P, Ochsner PE, Zimmerli W. Management of infection associated with total hip arthroplasty according to a treatment algorithm. Infection. 2004;32:222–8.CrossRefPubMed Giulieri SG, Graber P, Ochsner PE, Zimmerli W. Management of infection associated with total hip arthroplasty according to a treatment algorithm. Infection. 2004;32:222–8.CrossRefPubMed
16.
go back to reference Zimmerli W. Infection and musculoskeletal conditions: prosthetic-joint-associated infections. Best Pract Res Clin Rheumatol. 2006;20:1045–63.CrossRefPubMed Zimmerli W. Infection and musculoskeletal conditions: prosthetic-joint-associated infections. Best Pract Res Clin Rheumatol. 2006;20:1045–63.CrossRefPubMed
17.
go back to reference Barrett L, Atkins B. The clinical presentation of prosthetic joint infection. J Antimicrob Chemother. 2014;69(Suppl 1):i25–7.CrossRefPubMed Barrett L, Atkins B. The clinical presentation of prosthetic joint infection. J Antimicrob Chemother. 2014;69(Suppl 1):i25–7.CrossRefPubMed
18.
go back to reference McPherson EJ, Tontz W, Patzakis M, Woodsome C, Holtom P, Norris L, et al. Outcome of infected total knee utilizing a staging system for prosthetic joint infection. Am J Orthop. 1999;28:161–5.PubMed McPherson EJ, Tontz W, Patzakis M, Woodsome C, Holtom P, Norris L, et al. Outcome of infected total knee utilizing a staging system for prosthetic joint infection. Am J Orthop. 1999;28:161–5.PubMed
19.
go back to reference McPherson EJ, Woodson C, Holtom P, Roidis N, Shufelt C, Patzakis M. Periprosthetic total hip infection: outcomes using a staging system. Clin Orthop Relat Res 2002;8–15. McPherson EJ, Woodson C, Holtom P, Roidis N, Shufelt C, Patzakis M. Periprosthetic total hip infection: outcomes using a staging system. Clin Orthop Relat Res 2002;8–15.
20.
go back to reference Romanò CL, Romanò D, Logoluso N, Drago L. Bone and joint infections in adults: a comprehensive classification proposal. Eur Orthop Traumatol. 2011;1:207–17.CrossRefPubMedPubMedCentral Romanò CL, Romanò D, Logoluso N, Drago L. Bone and joint infections in adults: a comprehensive classification proposal. Eur Orthop Traumatol. 2011;1:207–17.CrossRefPubMedPubMedCentral
21.
go back to reference Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, et al. Executive summary: diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2013;56:1–10.CrossRefPubMed Osmon DR, Berbari EF, Berendt AR, Lew D, Zimmerli W, Steckelberg JM, et al. Executive summary: diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2013;56:1–10.CrossRefPubMed
22.
go back to reference Shohat N, Bauer T, Buttaro M, Budhiparama N, Cashman J, Della Valle CJ, et al. Hip and knee section, what is the definition of a periprosthetic joint infection (PJI) of the knee and the hip? Can the same criteria be used for both joints?: proceedings of international consensus on orthopedic infections. J Arthroplast. 2019;34:S325–7.CrossRef Shohat N, Bauer T, Buttaro M, Budhiparama N, Cashman J, Della Valle CJ, et al. Hip and knee section, what is the definition of a periprosthetic joint infection (PJI) of the knee and the hip? Can the same criteria be used for both joints?: proceedings of international consensus on orthopedic infections. J Arthroplast. 2019;34:S325–7.CrossRef
23.
go back to reference Parvizi J, Zmistowski B, Berbari EF, Bauer TW, Springer BD, Della Valle CJ, et al. New definition for periprosthetic joint infection: from the Workgroup of the Musculoskeletal Infection Society. Clin Orthop Relat Res. 2011;469:2992–4.CrossRefPubMedPubMedCentral Parvizi J, Zmistowski B, Berbari EF, Bauer TW, Springer BD, Della Valle CJ, et al. New definition for periprosthetic joint infection: from the Workgroup of the Musculoskeletal Infection Society. Clin Orthop Relat Res. 2011;469:2992–4.CrossRefPubMedPubMedCentral
24.
go back to reference Parvizi J, Tan TL, Goswami K, Higuera C, Della Valle C, Chen AF, et al. The 2018 definition of periprosthetic hip and knee infection: an evidence-based and validated criteria. J Arthroplasty. 2018;33:1309–1314.e2.CrossRefPubMed Parvizi J, Tan TL, Goswami K, Higuera C, Della Valle C, Chen AF, et al. The 2018 definition of periprosthetic hip and knee infection: an evidence-based and validated criteria. J Arthroplasty. 2018;33:1309–1314.e2.CrossRefPubMed
25.
go back to reference Patel R, Alijanipour P, Parvizi J. Advancements in diagnosing periprosthetic joint infections after total hip and knee arthroplasty. Open Orthop J. 2016;10:654–61.CrossRefPubMedPubMedCentral Patel R, Alijanipour P, Parvizi J. Advancements in diagnosing periprosthetic joint infections after total hip and knee arthroplasty. Open Orthop J. 2016;10:654–61.CrossRefPubMedPubMedCentral
26.
go back to reference Lee YS, Koo K-H, Kim HJ, Tian S, Kim T-Y, Maltenfort MG, et al. Synovial fluid biomarkers for the diagnosis of periprosthetic joint infection: a systematic review and meta-analysis. J Bone Joint Surg Am. 2017;99:2077–84.CrossRefPubMed Lee YS, Koo K-H, Kim HJ, Tian S, Kim T-Y, Maltenfort MG, et al. Synovial fluid biomarkers for the diagnosis of periprosthetic joint infection: a systematic review and meta-analysis. J Bone Joint Surg Am. 2017;99:2077–84.CrossRefPubMed
27.
go back to reference Deirmengian C, Kardos K, Kilmartin P, Cameron A, Schiller K, Parvizi J. Diagnosing periprosthetic joint infection: has the era of the biomarker arrived? Clin Orthop Relat Res. 2014;472:3254–62.CrossRefPubMedPubMedCentral Deirmengian C, Kardos K, Kilmartin P, Cameron A, Schiller K, Parvizi J. Diagnosing periprosthetic joint infection: has the era of the biomarker arrived? Clin Orthop Relat Res. 2014;472:3254–62.CrossRefPubMedPubMedCentral
28.
go back to reference Ting NT, Della Valle CJ. Diagnosis of periprosthetic joint infection-an algorithm-based approach. J Arthroplast. 2017;32:2047–50.CrossRef Ting NT, Della Valle CJ. Diagnosis of periprosthetic joint infection-an algorithm-based approach. J Arthroplast. 2017;32:2047–50.CrossRef
29.
go back to reference Zmistowski B, Della Valle C, Bauer TW, Malizos KN, Alavi A, Bedair H, et al. Diagnosis of periprosthetic joint infection. J Orthop Res. 2014;32(Suppl 1):S98–107.PubMed Zmistowski B, Della Valle C, Bauer TW, Malizos KN, Alavi A, Bedair H, et al. Diagnosis of periprosthetic joint infection. J Orthop Res. 2014;32(Suppl 1):S98–107.PubMed
30.
go back to reference Parvizi J, Ghanem E, Sharkey P, Aggarwal A, Burnett RSJ, Barrack RL. Diagnosis of infected total knee: findings of a multicenter database. Clin Orthop Relat Res. 2008;466:2628–33.CrossRefPubMedPubMedCentral Parvizi J, Ghanem E, Sharkey P, Aggarwal A, Burnett RSJ, Barrack RL. Diagnosis of infected total knee: findings of a multicenter database. Clin Orthop Relat Res. 2008;466:2628–33.CrossRefPubMedPubMedCentral
31.
go back to reference Abdel Karim M, Andrawis J, Bengoa F, Bracho C, Compagnoni R, Cross M, et al. Hip and knee section, diagnosis, algorithm: proceedings of international consensus on orthopedic infections. J Arthroplast. 2019;34:S339–50.CrossRef Abdel Karim M, Andrawis J, Bengoa F, Bracho C, Compagnoni R, Cross M, et al. Hip and knee section, diagnosis, algorithm: proceedings of international consensus on orthopedic infections. J Arthroplast. 2019;34:S339–50.CrossRef
32.
go back to reference Signore A, Sconfienza LM, Borens O, Glaudemans AWJM, Cassar-Pullicino V, Trampuz A, et al. Consensus document for the diagnosis of prosthetic joint infections: a joint paper by the EANM, EBJIS, and ESR (with ESCMID endorsement). Eur J Nucl Med Mol Imaging. 2019;46:971–88.CrossRefPubMedPubMedCentral Signore A, Sconfienza LM, Borens O, Glaudemans AWJM, Cassar-Pullicino V, Trampuz A, et al. Consensus document for the diagnosis of prosthetic joint infections: a joint paper by the EANM, EBJIS, and ESR (with ESCMID endorsement). Eur J Nucl Med Mol Imaging. 2019;46:971–88.CrossRefPubMedPubMedCentral
33.
go back to reference Della Valle CJ, Scher DM, Kim YH, Oxley CM, Desai P, Zuckerman JD, et al. The role of intraoperative Gram stain in revision total joint arthroplasty. J Arthroplast. 1999;14:500–4.CrossRef Della Valle CJ, Scher DM, Kim YH, Oxley CM, Desai P, Zuckerman JD, et al. The role of intraoperative Gram stain in revision total joint arthroplasty. J Arthroplast. 1999;14:500–4.CrossRef
34.
go back to reference Talbot BS, Weinberg EP. MR imaging with metal-suppression sequences for evaluation of total joint arthroplasty. Radiographics. 2016;36:209–25.CrossRefPubMed Talbot BS, Weinberg EP. MR imaging with metal-suppression sequences for evaluation of total joint arthroplasty. Radiographics. 2016;36:209–25.CrossRefPubMed
35.
go back to reference Scher DM, Pak K, Lonner JH, Finkel JE, Zuckerman JD, Di Cesare PE. The predictive value of indium-111 leukocyte scans in the diagnosis of infected total hip, knee, or resection arthroplasties. J Arthroplast. 2000;15:295–300.CrossRef Scher DM, Pak K, Lonner JH, Finkel JE, Zuckerman JD, Di Cesare PE. The predictive value of indium-111 leukocyte scans in the diagnosis of infected total hip, knee, or resection arthroplasties. J Arthroplast. 2000;15:295–300.CrossRef
36.
go back to reference Ouyang Z, Li H, Liu X, Zhai Z, Li X. Prosthesis infection: diagnosis after total joint arthroplasty with three-phase bone scintigraphy. Ann Nucl Med. 2014;28:994–1003.CrossRefPubMed Ouyang Z, Li H, Liu X, Zhai Z, Li X. Prosthesis infection: diagnosis after total joint arthroplasty with three-phase bone scintigraphy. Ann Nucl Med. 2014;28:994–1003.CrossRefPubMed
37.
go back to reference Aalirezaie A, Bauer TW, Fayaz H, Griffin W, Higuera CA, Krenn V, et al. Hip and knee section, diagnosis, reimplantation: proceedings of international consensus on orthopedic infections. J Arthroplast. 2019;34:S369–79.CrossRef Aalirezaie A, Bauer TW, Fayaz H, Griffin W, Higuera CA, Krenn V, et al. Hip and knee section, diagnosis, reimplantation: proceedings of international consensus on orthopedic infections. J Arthroplast. 2019;34:S369–79.CrossRef
38.
go back to reference Jung J, Schmid NV, Kelm J, Schmitt E, Anagnostakos K. Complications after spacer implantation in the treatment of hip joint infections. Int J Med Sci. 2009;6:265–73.CrossRefPubMedPubMedCentral Jung J, Schmid NV, Kelm J, Schmitt E, Anagnostakos K. Complications after spacer implantation in the treatment of hip joint infections. Int J Med Sci. 2009;6:265–73.CrossRefPubMedPubMedCentral
39.
go back to reference Anagnostakos K, Jung J, Schmid NV, Schmitt E, Kelm J. Mechanical complications and reconstruction strategies at the site of hip spacer implantation. Int J Med Sci. 2009;6:274–9.CrossRefPubMedPubMedCentral Anagnostakos K, Jung J, Schmid NV, Schmitt E, Kelm J. Mechanical complications and reconstruction strategies at the site of hip spacer implantation. Int J Med Sci. 2009;6:274–9.CrossRefPubMedPubMedCentral
Metadata
Title
Prosthetic joint infections: diagnosis, management, and complications of the two-stage replacement arthroplasty
Authors
Jack Porrino
Annie Wang
Austin Moats
Hyojeong Mulcahy
Kimia Kani
Publication date
01-06-2020
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 6/2020
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-020-03389-w

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