Skip to main content
Top
Published in: Skeletal Radiology 11/2017

01-11-2017 | Scientific Article

Ultrasonographic changes after steroid injection in carpal tunnel syndrome

Authors: Yeon Soo Lee, Eunseok Choi

Published in: Skeletal Radiology | Issue 11/2017

Login to get access

Abstract

Objective

To determine the ultrasonographic changes after steroid injection in carpal tunnel syndrome (CTS) and to evaluate the diagnostic value of ultrasound in post-treatment examination with clinical correlation.

Materials and methods

Twenty-seven wrists with idiopathic CTS after a single injection of 40 mg of prednisolone hydrochloride were prospectively studied using a high-resolution ultrasound. Axial images of the wrists were obtained at the level of the distal radius, pisiform and hamate prior to and 1, 4 and 8 weeks after steroid injection. The cross-sectional area (CSA, mm2) and flattening ratio (FR) of the median nerve were measured. The bowing of the flexor retinaculum (palmar displacement: PD, mm) and the transverse sliding distance of the median nerve (TSD, mm) during flexion-extension of the index finger were computed. Pre- and post-injection ultrasonographic findings were analyzed in relation to clinical parameters such as pain score.

Results

At all levels of the wrist, the CSA decreased significantly at 1 week after the injection, which continued to 8 weeks post-injection. The PD also diminished significantly 1 week after the injection. Furthermore, the TSD significantly increased from 1 week after injection, which lasted to the end of this study. The CSA, PD and TSD showed significant correlation with improvement of pain scores.

Conclusion

Ultrasound is useful in follow-up examinations of CTS. Significant ultrasound findings after steroid injections in CTS include decreased swelling of the median nerve, decreased bowing of the flexor retinaculum and increased mobility of the median nerve. All of them significantly correlate with clinical symptoms.
Literature
1.
go back to reference Beekman R, Visser LH. Sonography in the diagnosis of carpal tunnel syndrome: a critical review of the literature. Muscle Nerve. 2003;27(1):26–33.CrossRefPubMed Beekman R, Visser LH. Sonography in the diagnosis of carpal tunnel syndrome: a critical review of the literature. Muscle Nerve. 2003;27(1):26–33.CrossRefPubMed
2.
go back to reference Nathan PA, Keniston RC, Meadows KD, Lockwood RS. Predictive value of nerve conduction measurements at the carpal tunnel. Muscle Nerve. 1993;16(12):1377–82.CrossRefPubMed Nathan PA, Keniston RC, Meadows KD, Lockwood RS. Predictive value of nerve conduction measurements at the carpal tunnel. Muscle Nerve. 1993;16(12):1377–82.CrossRefPubMed
3.
go back to reference Padua L, LoMonaco M, Gregori B, Valente EM, Padua R, Tonali P. Neurophysiological classification and sensitivity in 500 carpal tunnel syndrome hands. Acta Neurol Scand. 1997;96(4):211–7.CrossRefPubMed Padua L, LoMonaco M, Gregori B, Valente EM, Padua R, Tonali P. Neurophysiological classification and sensitivity in 500 carpal tunnel syndrome hands. Acta Neurol Scand. 1997;96(4):211–7.CrossRefPubMed
4.
go back to reference Duncan I, Sullivan P, Lomas F. Sonography in the diagnosis of carpal tunnel syndrome. AJR Am J Roentgenol. 1999;173(3):681–4.CrossRefPubMed Duncan I, Sullivan P, Lomas F. Sonography in the diagnosis of carpal tunnel syndrome. AJR Am J Roentgenol. 1999;173(3):681–4.CrossRefPubMed
5.
go back to reference Buchberger W, Schön G, Strasser K, Jungwirth W. High-resolution ultrasonography of the carpal tunnel. J Ultrasound Med. 1991;10(10):531–7.CrossRefPubMed Buchberger W, Schön G, Strasser K, Jungwirth W. High-resolution ultrasonography of the carpal tunnel. J Ultrasound Med. 1991;10(10):531–7.CrossRefPubMed
6.
go back to reference Wong SM, Griffith JF, Hui AC, Lo SK, Fu M, Wong KS. Carpal tunnel syndrome: diagnostic usefulness of sonography. Radiology. 2004;232(1):93–9.CrossRefPubMed Wong SM, Griffith JF, Hui AC, Lo SK, Fu M, Wong KS. Carpal tunnel syndrome: diagnostic usefulness of sonography. Radiology. 2004;232(1):93–9.CrossRefPubMed
7.
go back to reference Junck AD, Escobedo EM, Lipa BM, et al. Reliability assessment of various sonographic techniques for evaluating carpal tunnel syndrome. J Ultrasound Med. 2015;34(11):2077–88.CrossRefPubMedPubMedCentral Junck AD, Escobedo EM, Lipa BM, et al. Reliability assessment of various sonographic techniques for evaluating carpal tunnel syndrome. J Ultrasound Med. 2015;34(11):2077–88.CrossRefPubMedPubMedCentral
8.
go back to reference Buchberger W, Judmaier W, Birbamer G, Lener M, Schmidauer C. Carpal tunnel syndrome: diagnosis with high-resolution sonography. AJR Am J Roentgenol. 1992;159(4):793–8.CrossRefPubMed Buchberger W, Judmaier W, Birbamer G, Lener M, Schmidauer C. Carpal tunnel syndrome: diagnosis with high-resolution sonography. AJR Am J Roentgenol. 1992;159(4):793–8.CrossRefPubMed
9.
10.
go back to reference McDonagh C, Alexander M, Kane D. The role of ultrasound in the diagnosis and management of carpal tunnel syndrome: a new paradigm. Rheumatology. 2015;54(1):9–19.CrossRefPubMed McDonagh C, Alexander M, Kane D. The role of ultrasound in the diagnosis and management of carpal tunnel syndrome: a new paradigm. Rheumatology. 2015;54(1):9–19.CrossRefPubMed
11.
go back to reference Yurdakul OV, Mesci N, Çetinkaya Y, Geler KD. Diagnostic significance of ultrasonographic measurements and median-ulnar ratio in carpal tunnel syndrome: correlation with nerve conduction studies. J Clin Neurol. 2016;12(3):289–94.CrossRefPubMedPubMedCentral Yurdakul OV, Mesci N, Çetinkaya Y, Geler KD. Diagnostic significance of ultrasonographic measurements and median-ulnar ratio in carpal tunnel syndrome: correlation with nerve conduction studies. J Clin Neurol. 2016;12(3):289–94.CrossRefPubMedPubMedCentral
12.
go back to reference Chen YT, Williams L, Zak MJ, Fredericson M. Review of ultrasonography in the diagnosis of carpal tunnel syndrome and a proposed scanning protocol. J Ultrasound Med. 2016;35(11):2311–24.CrossRefPubMed Chen YT, Williams L, Zak MJ, Fredericson M. Review of ultrasonography in the diagnosis of carpal tunnel syndrome and a proposed scanning protocol. J Ultrasound Med. 2016;35(11):2311–24.CrossRefPubMed
13.
go back to reference Nakamichi K, Tachibana S. Restricted motion of the median nerve in carpal tunnel syndrome. J Hand Surg Br. 1995;20(4):460–4.CrossRefPubMed Nakamichi K, Tachibana S. Restricted motion of the median nerve in carpal tunnel syndrome. J Hand Surg Br. 1995;20(4):460–4.CrossRefPubMed
14.
go back to reference Yoshii Y, Ishii T, Tung WL, Sakai S, Amadio PC. Median nerve deformation and displacement in the carpal tunnel during finger motion. J Orthop Res. 2013;31(12):1876–80.CrossRefPubMed Yoshii Y, Ishii T, Tung WL, Sakai S, Amadio PC. Median nerve deformation and displacement in the carpal tunnel during finger motion. J Orthop Res. 2013;31(12):1876–80.CrossRefPubMed
15.
go back to reference Ooi CC, Wong SK, Tan AB, et al. Diagnostic criteria of carpal tunnel syndrome using high-resolution ultrasonography: correlation with nerve conduction studies. Skelet Radiol. 2014;43(10):1387–94.CrossRef Ooi CC, Wong SK, Tan AB, et al. Diagnostic criteria of carpal tunnel syndrome using high-resolution ultrasonography: correlation with nerve conduction studies. Skelet Radiol. 2014;43(10):1387–94.CrossRef
16.
go back to reference Kang HJ, Yoon JS. Effect of finger motion on transverse median nerve movement in the carpal tunnel. Muscle Nerve. 2016;54(4):738–42.CrossRefPubMed Kang HJ, Yoon JS. Effect of finger motion on transverse median nerve movement in the carpal tunnel. Muscle Nerve. 2016;54(4):738–42.CrossRefPubMed
17.
go back to reference Hagebeuk EE, de Weerd AW. Clinical and electrophysiological follow-up after local steroid injection in the carpal tunnel syndrome. Clin Neurophysiol. 2004;115(6):1464–8.CrossRefPubMed Hagebeuk EE, de Weerd AW. Clinical and electrophysiological follow-up after local steroid injection in the carpal tunnel syndrome. Clin Neurophysiol. 2004;115(6):1464–8.CrossRefPubMed
18.
go back to reference Smidt MH, Visser LH. Carpal tunnel syndrome: clinical and sonographic follow-up after surgery. Muscle Nerve. 2008;38(2):987–91.CrossRefPubMed Smidt MH, Visser LH. Carpal tunnel syndrome: clinical and sonographic follow-up after surgery. Muscle Nerve. 2008;38(2):987–91.CrossRefPubMed
19.
go back to reference Abicalaf CA, de Barros N, Sernik RA, et al. Ultrasound evaluation of patients with carpal tunnel syndrome before and after endoscopic release of the transverse carpal ligament. Clin Radiol. 2007;62(9):891–4.CrossRefPubMed Abicalaf CA, de Barros N, Sernik RA, et al. Ultrasound evaluation of patients with carpal tunnel syndrome before and after endoscopic release of the transverse carpal ligament. Clin Radiol. 2007;62(9):891–4.CrossRefPubMed
20.
go back to reference Inui A, Nishimoto H, Mifune Y, Kokubu T, Sakata R, Kurosaka M. Ultrasound measurement of median nerve cross-sectional area at the inlet and outlet of carpal tunnel after carpal tunnel release compared to electrodiagnostic findings. Arch Orthop Trauma Surg. 2016;136(9):1325–30.CrossRefPubMed Inui A, Nishimoto H, Mifune Y, Kokubu T, Sakata R, Kurosaka M. Ultrasound measurement of median nerve cross-sectional area at the inlet and outlet of carpal tunnel after carpal tunnel release compared to electrodiagnostic findings. Arch Orthop Trauma Surg. 2016;136(9):1325–30.CrossRefPubMed
21.
go back to reference Kapuścińska K, Urbanik A. Efficacy of high frequency ultrasound in postoperative evaluation of carpal tunnel syndrome treatment. J Ultrason. 2016;16(64):16–24.CrossRefPubMedPubMedCentral Kapuścińska K, Urbanik A. Efficacy of high frequency ultrasound in postoperative evaluation of carpal tunnel syndrome treatment. J Ultrason. 2016;16(64):16–24.CrossRefPubMedPubMedCentral
22.
go back to reference Jeong JS, Yoon JS, Kim SJ, et al. Usefulness of ultrasonography to predict response to injection therapy in carpal tunnel syndrome. Ann Rehabil Med. 2011;35(3):388–94.CrossRefPubMedPubMedCentral Jeong JS, Yoon JS, Kim SJ, et al. Usefulness of ultrasonography to predict response to injection therapy in carpal tunnel syndrome. Ann Rehabil Med. 2011;35(3):388–94.CrossRefPubMedPubMedCentral
23.
24.
go back to reference Karadaş O, Omaç OK, Tok F, Ozgül A, Odabaşi Z. Effects of steroid with repetitive procaine HCl injection in the management of carpal tunnel syndrome: an ultrasonographic study. J Neurol. 2012;316(1-2):76–8. Karadaş O, Omaç OK, Tok F, Ozgül A, Odabaşi Z. Effects of steroid with repetitive procaine HCl injection in the management of carpal tunnel syndrome: an ultrasonographic study. J Neurol. 2012;316(1-2):76–8.
25.
go back to reference Bayrak IK, Bayrak AO, Tilki HE, Nural MS, Sunter T. Ultrasonography in carpal tunnel syndrome: comparison with electrophysiological stage and motor unit number estimate. Muscle Nerve. 2007;35(3):344–8.CrossRefPubMed Bayrak IK, Bayrak AO, Tilki HE, Nural MS, Sunter T. Ultrasonography in carpal tunnel syndrome: comparison with electrophysiological stage and motor unit number estimate. Muscle Nerve. 2007;35(3):344–8.CrossRefPubMed
26.
go back to reference Lu Y, Meng Z, Pan X, Qin L, Wang G. Value of high-frequency ultrasound in diagnosing carpal tunnel syndrome. Int J Clin Exp Med. 2015;8(12):22418–24.PubMedPubMedCentral Lu Y, Meng Z, Pan X, Qin L, Wang G. Value of high-frequency ultrasound in diagnosing carpal tunnel syndrome. Int J Clin Exp Med. 2015;8(12):22418–24.PubMedPubMedCentral
27.
go back to reference Ajeena IM, Al-Saad RH, Al-Mudhafar A, Hadi NR, Al-Aridhy SH. Ultrasonic assessment of females with carpal tunnel syndrome proved by nerve conduction study. Neural Plast. 2013;2013:754564.CrossRefPubMedPubMedCentral Ajeena IM, Al-Saad RH, Al-Mudhafar A, Hadi NR, Al-Aridhy SH. Ultrasonic assessment of females with carpal tunnel syndrome proved by nerve conduction study. Neural Plast. 2013;2013:754564.CrossRefPubMedPubMedCentral
28.
go back to reference Orman G, Ozben S, Huseyinoglu N, Duymus M, Orman KG. Ultrasound elastographic evaluation in the diagnosis of carpal tunnel syndrome: initial findings. Ultrasound Med Biol. 2013;39(7):1184–9.CrossRefPubMed Orman G, Ozben S, Huseyinoglu N, Duymus M, Orman KG. Ultrasound elastographic evaluation in the diagnosis of carpal tunnel syndrome: initial findings. Ultrasound Med Biol. 2013;39(7):1184–9.CrossRefPubMed
29.
go back to reference Azami A, Maleki N, Anari H, Iranparvar Alamdari M, Kalantarhormozi M, Tavosi Z. The diagnostic value of ultrasound compared with nerve conduction velocity in carpal tunnel syndrome. Int J Rheum Dis. 2014;17(6):612–20.CrossRefPubMed Azami A, Maleki N, Anari H, Iranparvar Alamdari M, Kalantarhormozi M, Tavosi Z. The diagnostic value of ultrasound compared with nerve conduction velocity in carpal tunnel syndrome. Int J Rheum Dis. 2014;17(6):612–20.CrossRefPubMed
30.
go back to reference Sarría L, Cabada T, Cozcolluela R, Martínez-Berganza T, García S. Carpal tunnel syndrome: usefulness of sonography. Eur Radiol. 2000;10(12):1920–5.CrossRefPubMed Sarría L, Cabada T, Cozcolluela R, Martínez-Berganza T, García S. Carpal tunnel syndrome: usefulness of sonography. Eur Radiol. 2000;10(12):1920–5.CrossRefPubMed
31.
go back to reference Keleş I, Karagülle Kendi AT, Aydin G, Zöğ SG, Orkun S. Diagnostic precision of ultrasonography in patients with carpal tunnel syndrome. Am J Phys Med Rehabil. 2005;84(6):443–50.CrossRefPubMed Keleş I, Karagülle Kendi AT, Aydin G, Zöğ SG, Orkun S. Diagnostic precision of ultrasonography in patients with carpal tunnel syndrome. Am J Phys Med Rehabil. 2005;84(6):443–50.CrossRefPubMed
32.
go back to reference Elsaman AM, Thabit MN, Radwan AR, Ohrndorf S. Idiopathic carpal tunnel syndrome: evaluation of the depth of the carpal tunnel by ultrasonography. Ultrasound Med Biol. 2015;41(11):2827–35.CrossRefPubMed Elsaman AM, Thabit MN, Radwan AR, Ohrndorf S. Idiopathic carpal tunnel syndrome: evaluation of the depth of the carpal tunnel by ultrasonography. Ultrasound Med Biol. 2015;41(11):2827–35.CrossRefPubMed
33.
go back to reference Roll SC, Case-Smith J, Evans KD. Diagnostic accuracy of ultrasonography vs. electromyography in carpal tunnel syndrome: a systematic review of literature. Ultrasound Med Biol. 2011;37(10):1539–53.CrossRefPubMed Roll SC, Case-Smith J, Evans KD. Diagnostic accuracy of ultrasonography vs. electromyography in carpal tunnel syndrome: a systematic review of literature. Ultrasound Med Biol. 2011;37(10):1539–53.CrossRefPubMed
35.
go back to reference Kim JK, Koh YD, Kim JO, Choi SW. Changes in clinical symptoms, functions, and the median nerve cross-sectional area at the carpal tunnel inlet after open carpal tunnel release. Clin Orthop Surg. 2016;8(3):298–302.CrossRefPubMedPubMedCentral Kim JK, Koh YD, Kim JO, Choi SW. Changes in clinical symptoms, functions, and the median nerve cross-sectional area at the carpal tunnel inlet after open carpal tunnel release. Clin Orthop Surg. 2016;8(3):298–302.CrossRefPubMedPubMedCentral
36.
go back to reference Mondelli M, Filippou G, Aretini A, Frediani B, Reale F. Ultrasonography before and after surgery in carpal tunnel syndrome and relationship with clinical and electrophysiological findings. A new outcome predictor? Scand J Rheumatol. 2008;37(3):219–24.CrossRefPubMed Mondelli M, Filippou G, Aretini A, Frediani B, Reale F. Ultrasonography before and after surgery in carpal tunnel syndrome and relationship with clinical and electrophysiological findings. A new outcome predictor? Scand J Rheumatol. 2008;37(3):219–24.CrossRefPubMed
37.
go back to reference Oh WT, Kang HJ, Koh IH, Jang JY, Choi YR. Morphologic change of nerve and symptom relief are similar after mini-incision and endoscopic carpal tunnel release: a randomized trial. BMC Musculoskelet Disord. 2017;18(1):65.CrossRefPubMedPubMedCentral Oh WT, Kang HJ, Koh IH, Jang JY, Choi YR. Morphologic change of nerve and symptom relief are similar after mini-incision and endoscopic carpal tunnel release: a randomized trial. BMC Musculoskelet Disord. 2017;18(1):65.CrossRefPubMedPubMedCentral
38.
go back to reference Naranjo A, Ojeda S, Rúa-Figueroa I, Garcia-Duque O, Fernández-Palacios J, Carmona L. Limited value of ultrasound assessment in patients with poor outcome after carpal tunnel release surgery. Scand J Rheumatol. 2010;39(5):409–12.CrossRefPubMed Naranjo A, Ojeda S, Rúa-Figueroa I, Garcia-Duque O, Fernández-Palacios J, Carmona L. Limited value of ultrasound assessment in patients with poor outcome after carpal tunnel release surgery. Scand J Rheumatol. 2010;39(5):409–12.CrossRefPubMed
39.
go back to reference Meys V, Thissen S, Rozeman S, Beekman R. Prognostic factors in carpal tunnel syndrome treated with a corticosteroid injection. Muscle Nerve. 2011;44(5):763–8.CrossRefPubMed Meys V, Thissen S, Rozeman S, Beekman R. Prognostic factors in carpal tunnel syndrome treated with a corticosteroid injection. Muscle Nerve. 2011;44(5):763–8.CrossRefPubMed
Metadata
Title
Ultrasonographic changes after steroid injection in carpal tunnel syndrome
Authors
Yeon Soo Lee
Eunseok Choi
Publication date
01-11-2017
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 11/2017
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-017-2738-y

Other articles of this Issue 11/2017

Skeletal Radiology 11/2017 Go to the issue

Browser's Notes

Browser’s notes