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Skeletal Radiology
Published in: Skeletal Radiology 11/2017

01-11-2017 | Scientific Article

Normative values for CT-based texture analysis of vertebral bodies in dual X-ray absorptiometry-confirmed, normally mineralized subjects

Authors: Manoj Mannil, Matthias Eberhard, Anton S. Becker, Denise Schönenberg, Georg Osterhoff, Diana P. Frey, Ender Konukoglu, Hatem Alkadhi, Roman Guggenberger

Published in: Skeletal Radiology | Issue 11/2017

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Abstract

Objectives

To develop age-, gender-, and regional-specific normative values for texture analysis (TA) of spinal computed tomography (CT) in subjects with normal bone mineral density (BMD), as defined by dual X-ray absorptiometry (DXA), and to determine age-, gender-, and regional-specific differences.

Materials and methods

In this retrospective, IRB-approved study, TA was performed on sagittal CT bone images of the thoracic and lumbar spine using dedicated software (MaZda) in 141 individuals with normal DXA BMD findings. Numbers of female and male subjects were balanced in each of six age decades. Three hundred and five TA features were analyzed in thoracic and lumbar vertebrae using free-hand regions-of-interest. Intraclass correlation (ICC) coefficients were calculated for determining intra- and inter-observer agreement of each feature. Further dimension reduction was performed with correlation analyses.

Results

The TA features with an ICC < 0.81 indicating compromised intra- and inter-observer agreement and with Pearson correlation scores r > 0.8 with other features were excluded from further analysis for dimension reduction. From the remaining 31 texture features, a significant correlation with age was found for the features mean (r = −0.489, p < 0.001), variance (r = −0.681, p < 0.001), kurtosis (r = 0.273, p < 0.001), and WavEnLL_s4 (r = 0.273, p < 0.001). Significant differences were found between genders for various higher-level texture features (p < 0.001). Regional differences among the thoracic spine, thoracic–lumbar junction, and lumbar spine were found for most TA features (p < 0.021).

Conclusion

This study established normative values of TA features on CT images of the spine and showed age-, gender-, and regional-specific differences in individuals with normal BMD as defined by DXA.
Appendix
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Metadata
Title
Normative values for CT-based texture analysis of vertebral bodies in dual X-ray absorptiometry-confirmed, normally mineralized subjects
Authors
Manoj Mannil
Matthias Eberhard
Anton S. Becker
Denise Schönenberg
Georg Osterhoff
Diana P. Frey
Ender Konukoglu
Hatem Alkadhi
Roman Guggenberger
Publication date
01-11-2017
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 11/2017
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-017-2728-0

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