Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Skeletal Radiology
Published in: Skeletal Radiology 9/2016

01-09-2016 | Case Report

Recurrent surgical site infection of the spine diagnosed by dual 18F-NaF-bone PET/CT with early-phase scan

Authors: Jai-Joon Shim, Jeong Won Lee, Min Hyok Jeon, Sang Mi Lee

Published in: Skeletal Radiology | Issue 9/2016

Login to get access

Abstract

We report a case of a 31-year-old man who showed recurrently elevated level of the serum inflammatory marker C-reactive protein (CRP) after spinal operation. He underwent 18F-flurodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) and dual 18F-sodium-fluoride (18F-NaF) PET/CT with an additional early-phase scan to find a hidden inflammation focus. Only mildly increased 18F-FDG was found at the surgical site of T11 spine on 18F-FDG PET/CT. In contrast, dual 18F-NaF bone PET/CT with early-phase scan demonstrated focal active inflammation at the surgical site of T11 spine. After a revision operation of the T11 spine, serum CRP level decreased to the normal range without any symptom or sign of inflammation. Inflammatory focus in the surgical site of the spine can be detected with using dual 18F-NaF bone PET/CT scan with early-phase scan.
Literature
1.
Parchi PD, Evangelisti G, Andreani L, Girardi F, Darren L, Sama A, et al. Postoperative spine infections. Orthop Rev (Pavia). 2015;7(3):5900.CrossRef
2.
Mazzie JP, Brooks MK, Gnerre J. Imaging and management of postoperative spine infection. Neuroimaging Clin N Am. 2014;24(2):365–74.CrossRefPubMed
3.
Basu S, Zhuang H, Torigian DA, Rosenbaum J, Chen W, Alavi A. Functional imaging of inflammatory diseases using nuclear medicine techniques. Semin Nucl Med. 2009;39(2):124–45.CrossRefPubMed
4.
Wong KK, Piert M. Dynamic bone imaging with 99mTc-labeled diphosphonates and 18F-NaF: mechanisms and applications. J Nucl Med. 2013;54(4):590–9.CrossRefPubMed
5.
Watanabe T, Takase-Minegishi K, Ihata A, Kunishita Y, Kishimoto D, Kamiyama R, et al. F-FDG and F-NaF PET/CT demonstrate coupling of inflammation and accelerated bone turnover in rheumatoid arthritis. Mod Rheumatol. 2016;26(2):180–7.PubMed
6.
Freesmeyer M, Stecker FF, Schierz JH, Hofmann GO, Winkens T. First experience with early dynamic (18)F-NaF-PET/CT in patients with chronic osteomyelitis. Ann Nucl Med. 2014;28(4):314–21.CrossRefPubMed
7.
El-Maghraby TA, Moustafa HM, Pauwels EK. Nuclear medicine methods for evaluation of skeletal infection among other diagnostic modalities. Q J Nucl Med Mol Imaging. 2006;50(3):167–92.PubMed
8.
Brammen L, Palestro C, Sinzinger H. Radionuclide imaging: past, present and future outlook in the diagnosis of infected prosthetic joints. Hell J Nucl Med. 2015;18 Suppl 1:95–102.PubMed
9.
Love C, Palestro CJ. Radionuclide imaging of infection. J Nucl Med Technol. 2004;32(2):47–57.PubMed
10.
11.
Palestro CJ, Love C, Tronco GG, Tomas MB, Rini JN. Combined labeled leukocyte and technetium 99m sulfur colloid bone marrow imaging for diagnosing musculoskeletal infection. Radiographics. 2006;26(3):859–70.CrossRefPubMed
12.
Palestro CJ, Kim CK, Swyer AJ, Vallabhajosula S, Goldsmith SJ. Radionuclide diagnosis of vertebral osteomyelitis: indium-111-leukocyte and technetium-99m-methylene diphosphonate bone scintigraphy. J Nucl Med. 1991;32(10):1861–5.PubMed
13.
Fuster D, Tomas X, Mayoral M, Soriano A, Manchon F, Cardenal C, et al. Prospective comparison of whole-body (18)F-FDG PET/CT and MRI of the spine in the diagnosis of haematogenous spondylodiscitis. Eur J Nucl Med Mol Imaging. 2015;42(2):264–71.CrossRefPubMed
14.
15.
16.
Liu Y. Orthopedic surgery-related benign uptake on FDG-PET: case examples and pitfalls. Ann Nucl Med. 2009;23(8):701–8.CrossRefPubMed
Metadata
Title
Recurrent surgical site infection of the spine diagnosed by dual 18F-NaF-bone PET/CT with early-phase scan
Authors
Jai-Joon Shim
Jeong Won Lee
Min Hyok Jeon
Sang Mi Lee
Publication date
01-09-2016
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 9/2016
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-016-2429-0

Other articles of this Issue 9/2016

Skeletal Radiology 9/2016 Go to the issue

Case Report

Asymmetric epiphyseal closure of the femoral head as a potential cause of the primary cam lesion: a case report

Scientific Article

Evaluation of the disco-vertebral junction using ultrashort time-to-echo magnetic resonance imaging: inter-reader agreement and association with vertebral endplate lesions

Test Yourself: Answer

Chronic hip pain

Test Yourself: Question

Chronic hip pain

Review Article

Cross-sectional imaging of adult crystal and inflammatory arthropathies

Scientific Article

Significant associated MRI findings in patients with anterior cruciate ligament stump entrapment