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01-05-2012 | Scientific Article

Quantitative assessment of bone defect healing by multidetector CT in a pig model

Authors: Carolin Riegger, Patric Kröpil, Pascal Jungbluth, Rotem S. Lanzman, Falk R. Miese, Ahmad R. Hakimi, Mohssen Hakimi, Michael Wild, Gerald Antoch, Axel Scherer

Published in: Skeletal Radiology | Issue 5/2012

Abstract

Objective

To evaluate multidetector CT volumetry in the assessment of bone defect healing in comparison to histopathological findings in an animal model.

Materials and methods

In 16 mini-pigs, a circumscribed tibial bone defect was created. Multidetector CT (MDCT) of the tibia was performed on a 64-row scanner 42 days after the operation. The extent of bone healing was estimated quantitatively by MDCT volumetry using a commercially available software programme (syngo Volume, Siemens, Germany).The volume of the entire defect (including all pixels from −100 to 3,000 HU), the nonconsolidated areas (−100 to 500 HU), and areas of osseous consolidation (500 to 3,000 HU) were assessed and the extent of consolidation was calculated. Histomorphometry served as the reference standard.

Results

The extent of osseous consolidation in MDCT volumetry ranged from 19 to 92% (mean 65.4 ± 18.5%). There was a significant correlation between histologically visible newly formed bone and the extent of osseous consolidation on MDCT volumetry (r = 0.82, P < 0.0001). A significant negative correlation was detected between osseous consolidation on MDCT and histological areas of persisting defect (r = −0.9, P < 0.0001).

Conclusion

MDCT volumetry is a promising tool for noninvasive monitoring of bone healing, showing excellent correlation with histomorphometry.

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Title: Quantitative assessment of bone defect healing by multidetector CT in a pig model
Authors: Carolin Riegger
Patric Kröpil
Pascal Jungbluth
Rotem S. Lanzman
Falk R. Miese
Ahmad R. Hakimi
Mohssen Hakimi
Michael Wild
Gerald Antoch
Axel Scherer
Publication date: 01-05-2012
Publisher: Springer-Verlag
Published in: Skeletal Radiology / Issue 5/2012
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI: https://doi.org/10.1007/s00256-011-1203-6

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Quantitative assessment of bone defect healing by multidetector CT in a pig model

Abstract

Objective

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

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