Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Skeletal Radiology

01-12-2010 | Scientific Article

Morphologic imaging in muscular dystrophies and inflammatory myopathies

Published in: Skeletal Radiology | Issue 12/2010

Login to get access

Abstract

Objective

To determine if magnetic resonance imaging (MR imaging) is useful in the diagnostic workup of muscular dystrophies and idiopathic inflammatory myopathies for describing the topography of muscle involvement.

Materials and methods

MR imaging was performed in 31 patients: 8 with dystrophic myotony types 1 (n = 4) or 2 (n = 4); 11 with limb-girdle muscular dystrophy, including dysferlinopathy, calpainopathy, sarcoglycanopathy, and dystrophy associated with fukutin-related protein mutation; 3 with Becker muscular dystrophy; and 9 with idiopathic inflammatory myopathies, including polymyositis, dermatomyositis, and sporadic inclusion body myositis.

Results

Analysis of T1 images enabled us to describe the most affected muscles and the muscles usually spared for each muscular disease. In particular, examination of pelvis, thigh, and leg muscles demonstrated significant differences between the muscular diseases. On STIR images, hyperintensities were present in 62% of our patients with muscular dystrophies.

Conclusion

A specific pattern of muscular involvement was established for each muscular disease. Hyperintensities observed on STIR images precede fatty degeneration and are not specific for inflammatory myopathies.
Literature
1.
Fischer D, Walter MC, Kesper K, et al. Diagnostic value of muscle MRI in differentiating LGMD2I from other LGMDs. J Neurol. 2005;252:538–47.CrossRefPubMed
2.
Schweitzer ME, Fort J. Cost-effectiveness of MR imaging in evaluating polymyositis. AJR Am J Roentgenol. 1995;165:1469–71.PubMed
3.
Stiglbauer R, Graninger W, Prayer L, et al. Polymyositis: MRI-appearance at 1.5 T and correlation to clinical findings. Clin Radiol. 1993;48:244–8.CrossRefPubMed
4.
Castillo J, Pumar JM, Rodriguez JR, et al. Magnetic resonance imaging of muscles in myotonic dystrophy. Eur J Radiol. 1993;17:141–4.CrossRefPubMed
5.
Damian MS, Bachmann G, Herrmann D, Dorndorf W. Magnetic resonance imaging of muscle and brain in myotonic dystrophy. J Neurol. 1993;240:8–12.CrossRefPubMed
6.
Kornblum C, Lutterbey G, Bogdanow M, et al. Distinct neuromuscular phenotypes in myotonic dystrophy types 1 and 2: a whole body highfield MRI study. J Neurol. 2006;253:753–61.CrossRefPubMed
7.
Lovitt S, Moore SL, Marden FA. The use of MRI in the evaluation of myopathy. Clin Neurophysiol. 2006;117:486–95.CrossRefPubMed
8.
Mercuri E, Bushby K, Ricci E, et al. Muscle MRI findings in patients with limb girdle muscular dystrophy with calpain 3 deficiency (LGMD2A) and early contractures. Neuromuscul Disord. 2005;15:164–71.CrossRefPubMed
9.
Schreiber A, Smith WL, Ionasescu V, et al. Magnetic resonance imaging of children with Duchenne muscular dystrophy. Pediatr Radiol. 1987;17:495–7.CrossRefPubMed
10.
Matsumura K, Nakano I, Fukuda N, Ikehira H, Tateno Y, Aoki Y. Proton spin-lattice relaxation time of Duchenne dystrophy skeletal muscle by magnetic resonance imaging. Muscle Nerve. 1988;1:97–102.CrossRef
11.
Fanin M, Nascimbeni AC, Fulizio L, Trevisan CP, Meznaric-Petrusa M, Angelini C. Loss of calpain-3 autocatalytic activity in LGMD2A patients with normal protein expression. J Pathol. 2003;163:1929–36.
12.
Cupler EJ, Bohlega S, Hessler R, McLean D, Stigsby B, Ahmad J. Miyoshi myopathy in Saudi Arabia: clinical, electrophysiological, histopathological and radiological features. Neuromuscul Disord. 1998;8:321–6.CrossRefPubMed
13.
Lodi R, Muntoni F, Taylor J, et al. Correlative MR imaging and 31P-MR spectroscopy study in sarcoglycan deficient limb girdle muscular dystrophy. Neuromuscul Disord. 1997;7:505–11.CrossRefPubMed
14.
Dion E, Cherin P. Use of muscular MRI in inflammatory myopathies (in French). Rev Med Interne. 2004;6:435–41.CrossRef
15.
Scott DL, Kingsley GH. Use of imaging to assess patients with muscle disease. Curr Opin Rheumatol. 2004;16:678–83.CrossRefPubMed
16.
Dion E, Cherin P, Payan C, et al. Magnetic resonance imaging criteria for distinguishing between inclusion body myositis and polymyositis. J Rheumatol. 2002;29:1897–906.PubMed
17.
18.
Mahjneh I, Lamminen AE, Udd B, et al. Muscle magnetic resonance imaging shows distinct diagnostic patterns in Welander and tibial muscular dystrophy. Acta Neurol Scand. 2004;110(2):87–93.CrossRefPubMed
19.
Kaplan PA, Helms CA, Dussault R, Anderson MW, Major NM. Musculoskeletal MRI. Philadelphia: Saunders; 2001.
20.
Meyer RA, Towse TF, Reid RW, Jayaraman RC, Wiseman RW, McCully KK. BOLD MRI mapping of transient hyperemia in skeletal muscle after single contractions. NMR Biomed. 2004;17:392–8.CrossRefPubMed
Metadata
Title
Morphologic imaging in muscular dystrophies and inflammatory myopathies
Publication date
01-12-2010
Published in
Skeletal Radiology / Issue 12/2010
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-010-0930-4