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Published in: Skeletal Radiology 12/2004

01-12-2004 | Newer Technology

The impact of technical conditions of X-ray imaging on reproducibility and precision of digital computer-assisted X-ray radiogrammetry (DXR)

Authors: A. Malich, J. Boettcher, A. Pfeil, D. Sauner, J. P. Heyne, A. Petrovitch, A. Hansch, W. Linss, W. A. Kaiser

Published in: Skeletal Radiology | Issue 12/2004

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Abstract

Objective

To evaluate the reproducibility of imaging and analysis for bone mineral density (BMD) determination using digital computer-assisted X-ray radiogrammetry (DXR; Pronosco X-posure, version V.2, Sectra Pronosco, Denmark); to verify potential factors that influence BMD extrapolation such as tube voltage, film-focus distance (FFD), film quality and brand (Kodak T-MAT-Plus, Konika SRH, Agfa Scopix), imaging technology (conventional, digital), imaging system (Kodak, Agfa) and exposure level (mAs); and to clarify whether DXR analysis based on printouts of digital images is comparable to analysis of conventional images.

Design and patients

The hand of a cadaver was X-rayed using varied parameters: 4–8 mAs, 40–52 kV, 90–130 cm FFD. Radiographs under standardised conditions were performed 10 times using a conventional machine (Philips Super 80 CP) and the printouts of a digital system (Digital Diagnost Philips Optimus) for the analysis of reproducibility. One image was scanned and analysed 10 times additionally for imaging reproducibility.

Results

Reliability error of the system for the imaging process using conventional radiographs-rays was 0.49% (standard conditions: 6 mAs, 40 kV, 1 m FFD), using printouts of digital images was 2.89% (4 mAs, 42 kV, 1 m FFD) and regarding the analysis process was 0.22%. BMD calculation is not affected by alterations in FFD (precision error 1.21%), mAs (0.83%) or film quality/brand (0.38%), but differs significantly depending on tube voltage (2.70%). The system was not able to analyse conventional images with tube voltages of 49/52 kV.

Conclusion

DXR technology is stable with most of the tested parameters. Normative data should exclusively be used for calculations using similar tube voltage or correction factors. All other parameters had no significant influence on the BMD calculation. Reproducibility is high. For technical reasons it is not recommended to use the printouts of digital images for BMD determination.
Literature
1.
go back to reference Barnett E, Nordin B. The radiological diagnosis of osteoporosis: a new approach. Clin Radiol 1960; 11:166–174.PubMed Barnett E, Nordin B. The radiological diagnosis of osteoporosis: a new approach. Clin Radiol 1960; 11:166–174.PubMed
2.
go back to reference Virtama P, Mahonen H. Thickness of the cortical layer as an estimate of mineral content of human finger bones. Br J Radiol 1960; 6:60–62. Virtama P, Mahonen H. Thickness of the cortical layer as an estimate of mineral content of human finger bones. Br J Radiol 1960; 6:60–62.
3.
go back to reference Wishart JM, Horowitz M, Bochner M, Need AG, Nordin BEC. Relationship between metacarpal morphometry, forearm and vertebral bone density and fractures in postmenopausal women. Br J Radiol 1993; 66:435–440.PubMed Wishart JM, Horowitz M, Bochner M, Need AG, Nordin BEC. Relationship between metacarpal morphometry, forearm and vertebral bone density and fractures in postmenopausal women. Br J Radiol 1993; 66:435–440.PubMed
4.
go back to reference Rosholm A, Hylsdrup L, Baeksgaard L, Grunkin M, Thodberg HH. Estimation of bone mineral density by digital X-ray radiogrammetry: theoretical background and clinical testing. Osteoporosis Int 2001; 12:961–969.CrossRef Rosholm A, Hylsdrup L, Baeksgaard L, Grunkin M, Thodberg HH. Estimation of bone mineral density by digital X-ray radiogrammetry: theoretical background and clinical testing. Osteoporosis Int 2001; 12:961–969.CrossRef
5.
go back to reference Hardin DS, Sy JP. Effects of growth hormone treatment in children with cystic fibrosis: the National Cooperative Growth Study experience. J Pediatr 1997; 131:65–69. Hardin DS, Sy JP. Effects of growth hormone treatment in children with cystic fibrosis: the National Cooperative Growth Study experience. J Pediatr 1997; 131:65–69.
6.
go back to reference Black DM, Palermo L, Sorensen T, et al. A normative reference database study for the Pronosco X-posure radiogrammetry system. J Clin Densitom 2001; 4:5-12.CrossRefPubMed Black DM, Palermo L, Sorensen T, et al. A normative reference database study for the Pronosco X-posure radiogrammetry system. J Clin Densitom 2001; 4:5-12.CrossRefPubMed
7.
go back to reference Anon. EXPO/DK-04: a clinical study to establish a normative reference database for the Pronosco X-posure system for Scandinavian Caucasian women. Clinical report V.2 20-11-2000 Anon. EXPO/DK-04: a clinical study to establish a normative reference database for the Pronosco X-posure system for Scandinavian Caucasian women. Clinical report V.2 20-11-2000
8.
go back to reference Wüster C, Wenzler M, Kappes J, Rehm C, Gühring T, Arnbjerg C. Digital X-ray radiogrammetry as a clinical method for estimating bone mineral density: a German reference database. J Bone Miner Res 2000; 15:298. Wüster C, Wenzler M, Kappes J, Rehm C, Gühring T, Arnbjerg C. Digital X-ray radiogrammetry as a clinical method for estimating bone mineral density: a German reference database. J Bone Miner Res 2000; 15:298.
9.
go back to reference Maffei L, Venarotti H, Treviso J, Sorensen TK, Nissen D. Digital X-ray radiogrammetry: a Hispanic normative reference database for the Pronosco X-posure system. J Bone Miner Res 2000; 15:304. Maffei L, Venarotti H, Treviso J, Sorensen TK, Nissen D. Digital X-ray radiogrammetry: a Hispanic normative reference database for the Pronosco X-posure system. J Bone Miner Res 2000; 15:304.
10.
go back to reference Yan J, Li M, Zhonhou L, et al. Normal values of forearm bone BMD and incidence of primary osteoporosis in Chinese women. Chinese J Osteoporos 2000; 6:30–32. Yan J, Li M, Zhonhou L, et al. Normal values of forearm bone BMD and incidence of primary osteoporosis in Chinese women. Chinese J Osteoporos 2000; 6:30–32.
11.
go back to reference Anon. XPO/TECH-016: reproducibility study for X-posure V.2: conventional image capture. Technical report 24-7-2000. Anon. XPO/TECH-016: reproducibility study for X-posure V.2: conventional image capture. Technical report 24-7-2000.
12.
go back to reference Malich A, Azhari T, Boehm T, Fleck M, Kaiser WA. Reproducibility of a commercially available computer aided detection (CAD) system. Eur J Radiol 2000; 36:170–174.CrossRefPubMed Malich A, Azhari T, Boehm T, Fleck M, Kaiser WA. Reproducibility of a commercially available computer aided detection (CAD) system. Eur J Radiol 2000; 36:170–174.CrossRefPubMed
13.
go back to reference Glastre C, Braillon P, David L, Cochat P, Meunier PJ, Delmas PD. Measurement of bone mineral content of the lumbar spine by dual energy X-ray absorptiometry in normal children: correlations with growth parameters. J Clin Endocrinol Metab 1990; 70:1330–1333.PubMed Glastre C, Braillon P, David L, Cochat P, Meunier PJ, Delmas PD. Measurement of bone mineral content of the lumbar spine by dual energy X-ray absorptiometry in normal children: correlations with growth parameters. J Clin Endocrinol Metab 1990; 70:1330–1333.PubMed
14.
go back to reference Njeh CF, Fuerst T, Hans D, Blake GM, Genant HK. Radiation exposure in bone mineral density assessment. Appl Radiat Isot 1999; 50:215–236.CrossRefPubMed Njeh CF, Fuerst T, Hans D, Blake GM, Genant HK. Radiation exposure in bone mineral density assessment. Appl Radiat Isot 1999; 50:215–236.CrossRefPubMed
15.
go back to reference Wünsche K, Wünsche B, Fähnrich H, et al. Ultrasound bone densitometry of the os calcis in children and adolescents. Calcif Tissue Int 2000; 67:349–355.CrossRefPubMed Wünsche K, Wünsche B, Fähnrich H, et al. Ultrasound bone densitometry of the os calcis in children and adolescents. Calcif Tissue Int 2000; 67:349–355.CrossRefPubMed
16.
go back to reference Malich A, Mainz J, John S, Böttcher K, Vogt S, Kaiser WA. Ultrasound based bone densitometry of the os calcis measured on asthmatic children using regional normative data. Eur Radiol 2002; 12(Suppl 1):284. Malich A, Mainz J, John S, Böttcher K, Vogt S, Kaiser WA. Ultrasound based bone densitometry of the os calcis measured on asthmatic children using regional normative data. Eur Radiol 2002; 12(Suppl 1):284.
17.
go back to reference Helboe AB, Juul K, Rosholm A, Andersen PB, Bjarnason NH. High short-term in-vivo precision of the Pronosco X-posure System on hand X-rays. J Bone Miner Soc 2001; 28(Suppl):335. Helboe AB, Juul K, Rosholm A, Andersen PB, Bjarnason NH. High short-term in-vivo precision of the Pronosco X-posure System on hand X-rays. J Bone Miner Soc 2001; 28(Suppl):335.
18.
go back to reference Malich A, Freesmeyer MG, Mentzel HJ, et al. Normative values of bone parameters of children and adolescents using digital computer-assisted radiogrammetry (DXR). J Clin Densitom 2003; 6:103–111.CrossRefPubMed Malich A, Freesmeyer MG, Mentzel HJ, et al. Normative values of bone parameters of children and adolescents using digital computer-assisted radiogrammetry (DXR). J Clin Densitom 2003; 6:103–111.CrossRefPubMed
19.
go back to reference Felsenberg D, Gowin W, Diessel E, Armbrust S, Mews J. Recent developments in DXA. Quality of new DXA/MXA-devices to densitometry and morphometry. Eur J Radiol 1995; 20:179–184.CrossRefPubMed Felsenberg D, Gowin W, Diessel E, Armbrust S, Mews J. Recent developments in DXA. Quality of new DXA/MXA-devices to densitometry and morphometry. Eur J Radiol 1995; 20:179–184.CrossRefPubMed
20.
go back to reference Boonen S, Cheng X, Nicholson PH, Verbeke G, Broos P, Dequeker J. The accuracy of peripheral skeletal assessment at the radius in estimating femoral bone density as measured by dual-energy X-ray absorptiometry: a comparative study of single-photon absorptiometry and computed tomography. J Intern Med 1997; 242:323–328.CrossRefPubMed Boonen S, Cheng X, Nicholson PH, Verbeke G, Broos P, Dequeker J. The accuracy of peripheral skeletal assessment at the radius in estimating femoral bone density as measured by dual-energy X-ray absorptiometry: a comparative study of single-photon absorptiometry and computed tomography. J Intern Med 1997; 242:323–328.CrossRefPubMed
21.
go back to reference Nordin BEC. Calcium, phosphate and magnesium metabolism. In: Clinical physiology and diagnostic procedures. Edinburgh: Churchill Livingstone, 1976:391–397, 512–516, 570–572. Nordin BEC. Calcium, phosphate and magnesium metabolism. In: Clinical physiology and diagnostic procedures. Edinburgh: Churchill Livingstone, 1976:391–397, 512–516, 570–572.
Metadata
Title
The impact of technical conditions of X-ray imaging on reproducibility and precision of digital computer-assisted X-ray radiogrammetry (DXR)
Authors
A. Malich
J. Boettcher
A. Pfeil
D. Sauner
J. P. Heyne
A. Petrovitch
A. Hansch
W. Linss
W. A. Kaiser
Publication date
01-12-2004
Publisher
Springer-Verlag
Published in
Skeletal Radiology / Issue 12/2004
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-004-0861-z

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