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Pediatric Radiology
Published in: Pediatric Radiology 3/2020

Open Access 01-03-2020 | Magnetic Resonance Imaging | Original Article

T1ρ-mapping for assessing knee joint cartilage in children with juvenile idiopathic arthritis — feasibility and repeatability

Authors: Anouk M. Barendregt, Valentina Mazzoli, J. Merlijn van den Berg, Taco W. Kuijpers, Mario Maas, Aart J. Nederveen, Robert Hemke

Published in: Pediatric Radiology | Issue 3/2020

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Abstract

Background

Ongoing arthritis in children with juvenile idiopathic arthritis (JIA) can result in cartilage damage.

Objective

To study the feasibility and repeatability of T1ρ for assessing knee cartilage in JIA and also to describe T1ρ values and study correlation between T1ρ and conventional MRI scores for disease activity.

Materials and methods

Thirteen children with JIA or suspected JIA underwent 3-tesla (T) knee MRI that included conventional sequences and a T1ρ sequence. Segmentation of knee cartilage was carried out on T1ρ images. We used intraclass correlation coefficient to study the repeatability of segmentation in a subset of five children. We used the juvenile arthritis MRI scoring system to discriminate inflamed from non-inflamed knees. The Mann-Whitney U and Spearman correlation compared T1ρ between children with and without arthritis on MRI and correlated T1ρ with the juvenile arthritis MRI score.

Results

All children successfully completed the MRI examination. No images were excluded because of poor quality. Repeatability of T1ρ measurement had an intraclass correlation coefficient (ICC) of 0.99 (P<0.001). We observed no structural cartilage damage and found no differences in T1ρ between children with (n=7) and without (n=6) inflamed knees (37.8 ms vs. 31.7 ms, P=0.20). However, we observed a moderate correlation between T1ρ values and the juvenile arthritis MRI synovitis score (r=0.59, P=0.04).

Conclusion

This pilot study suggests that T1ρ is a feasible and repeatable quantitative imaging technique in children. T1ρ values were associated with the juvenile arthritis MRI synovitis score.
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Metadata
Title
T1ρ-mapping for assessing knee joint cartilage in children with juvenile idiopathic arthritis — feasibility and repeatability
Authors
Anouk M. Barendregt
Valentina Mazzoli
J. Merlijn van den Berg
Taco W. Kuijpers
Mario Maas
Aart J. Nederveen
Robert Hemke
Publication date
01-03-2020
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Radiology / Issue 3/2020
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-019-04557-4

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