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Published in: Pediatric Radiology 11/2016

01-10-2016 | Original Article

Characteristic calcaneal ossification: an additional early radiographic finding in infants with fibrodysplasia ossificans progressiva

Authors: Sachi Hasegawa, Teresa Victoria, Hülya Kayserili, Elaine Zackai, Gen Nishimura, Nobuhiko Haga, Yasuharu Nakashima, Osamu Miyazaki, Hiroshi Kitoh

Published in: Pediatric Radiology | Issue 11/2016

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Abstract

Background

We have clinically encountered children with fibrodysplasia ossificans progressiva who had abnormal calcaneal ossification.

Objective

To evaluate whether calcaneal ossification variants are significant radiographic findings in children with fibrodysplasia ossificans progressiva.

Materials and methods

Lateral feet radiographs in nine children who fulfilled the diagnostic criteria of fibrodysplasia ossificans progressiva were reviewed. The studies were obtained during infancy or early childhood.

Results

Fourteen lateral foot radiographs of fibrodysplasia ossificans progressiva were available for this study (ages at examination: 1-104 months). Four children ages 2 months to 11 months showed double calcaneal ossification centers; 7 children had plantar calcaneal spurs that decreased in size with age. Overall, eight of nine children with fibrodysplasia ossificans progressiva demonstrated double calcaneal ossifications and/or plantar calcaneal spurs in infancy or childhood.

Conclusion

Double calcaneal ossification centers in early infancy and plantar calcaneal spurs in childhood are frequently seen in children with fibrodysplasia ossificans progressiva and may be a useful radiologic indicator for early diagnosis.
Literature
1.
go back to reference Shore EM, Xu M, Feldman GJ et al (2006) A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat Genet 38:525–527CrossRefPubMed Shore EM, Xu M, Feldman GJ et al (2006) A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat Genet 38:525–527CrossRefPubMed
2.
go back to reference Pignolo RJ, Shore EM, Kaplan FS (2013) Fibrodysplasia ossificans progressiva: diagnosis, management, and therapeutic horizons. Pediatr Endocrinol Rev 10:437–448PubMedPubMedCentral Pignolo RJ, Shore EM, Kaplan FS (2013) Fibrodysplasia ossificans progressiva: diagnosis, management, and therapeutic horizons. Pediatr Endocrinol Rev 10:437–448PubMedPubMedCentral
3.
go back to reference Nakashima Y, Haga N, Kitoh H et al (2010) Deformity of the great toe in fibrodysplasia ossificans progressiva. J Orthop Sci 15:804–809CrossRefPubMed Nakashima Y, Haga N, Kitoh H et al (2010) Deformity of the great toe in fibrodysplasia ossificans progressiva. J Orthop Sci 15:804–809CrossRefPubMed
4.
go back to reference Mishima K, Kitoh H, Katagiri T et al (2011) Early clinical and radiographic characteristics in fibrodysplasia ossificans progressiva: a report of two cases. J Bone Joint Surg Am 93, e52CrossRefPubMed Mishima K, Kitoh H, Katagiri T et al (2011) Early clinical and radiographic characteristics in fibrodysplasia ossificans progressiva: a report of two cases. J Bone Joint Surg Am 93, e52CrossRefPubMed
5.
go back to reference Mishima K, Kitoh H, Haga N et al (2014) Radiographic characteristics of the hand and cervical spine in fibrodysplasia ossificans progressiva. Intractable Rare Dis Res 3:46–51CrossRefPubMedPubMedCentral Mishima K, Kitoh H, Haga N et al (2014) Radiographic characteristics of the hand and cervical spine in fibrodysplasia ossificans progressiva. Intractable Rare Dis Res 3:46–51CrossRefPubMedPubMedCentral
7.
go back to reference Robinson HM (1976) Symmetrical reversed plantar calcaneal spurs in children. A normal variant? Radiology 119:187–188CrossRefPubMed Robinson HM (1976) Symmetrical reversed plantar calcaneal spurs in children. A normal variant? Radiology 119:187–188CrossRefPubMed
8.
go back to reference Sever JW (1930) Bifid os calcis. Surg Gynecol Obstet 50:1012–1013 Sever JW (1930) Bifid os calcis. Surg Gynecol Obstet 50:1012–1013
9.
go back to reference Ogden JA (1982) Anomalous multifocal ossification of the os calcis. Clin Orthop Relat Res 162:112–118PubMed Ogden JA (1982) Anomalous multifocal ossification of the os calcis. Clin Orthop Relat Res 162:112–118PubMed
10.
go back to reference Szaboky GT, Anderson JJ, Wiltsie RA (1970) Bifid os calcis. An anomalous ossification of the calcaneus. Clin Orthop Relat Res 68:136–137CrossRefPubMed Szaboky GT, Anderson JJ, Wiltsie RA (1970) Bifid os calcis. An anomalous ossification of the calcaneus. Clin Orthop Relat Res 68:136–137CrossRefPubMed
11.
go back to reference Cormier-Daire V, Savarirayan R, Unger S et al (2001) “Duplicate Calcaneus”: a rare developmental defect observed in several skeletal dysplasias. Pediatr Radiol 31:38–42CrossRefPubMed Cormier-Daire V, Savarirayan R, Unger S et al (2001) “Duplicate Calcaneus”: a rare developmental defect observed in several skeletal dysplasias. Pediatr Radiol 31:38–42CrossRefPubMed
12.
go back to reference Krakow D, Robertson SP, King LM et al (2004) Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis. Nat Genet 36:405–410CrossRefPubMed Krakow D, Robertson SP, King LM et al (2004) Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis. Nat Genet 36:405–410CrossRefPubMed
13.
Metadata
Title
Characteristic calcaneal ossification: an additional early radiographic finding in infants with fibrodysplasia ossificans progressiva
Authors
Sachi Hasegawa
Teresa Victoria
Hülya Kayserili
Elaine Zackai
Gen Nishimura
Nobuhiko Haga
Yasuharu Nakashima
Osamu Miyazaki
Hiroshi Kitoh
Publication date
01-10-2016
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Radiology / Issue 11/2016
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-016-3662-3

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