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Pediatric Radiology

Published in:

01-10-2012 | Original Article

Periventricular nodular heterotopia is related to severity of the hindbrain deformity in Chiari II malformation

Authors: Ayako Hino-Shishikura, Tetsu Niwa, Noriko Aida, Tetsuhiko Okabe, Tomoaki Nagaoka, Jun Shibasaki

Published in: Pediatric Radiology | Issue 10/2012

Abstract

Background

Knowledge of the occurrence of malformations of cortical development (MCDs) and its relationship to hindbrain deformity in Chiari II malformation (CIIM) is limited.

Objective

To assess malformations of cortical development and its relationship to hindbrain deformity regarding Chiari II malformation.

Materials and methods

Brain and cervical spinal MRI from 66 children (age range, 1-256 days; mean age, 22.3 days) with Chiari II malformation were retrospectively reviewed. If present, the type, number and location of malformations of cortical development were recorded. Hindbrain deformity was assessed for the level of the medullary kink, the descent of the pons and the shape of the fourth ventricle; these parameters were compared in children with and without malformations of cortical development.

Results

Twenty children with malformations of cortical development were identified. Only periventricular nodular heterotopia was noted. The median level of the medullary kink was significantly lower in children with malformations of cortical development compared with children without it (P = 0.037). A low pontomesencephalic junction was identified more frequently in children with malformations of cortical development (65.0%), relative to children without malformations of cortical development (34.8%) (P = 0.045). The fourth ventricular shape was not significantly different in children with or without malformations of cortical development (P = 0.684).

Conclusion

Periventricular nodular heterotopia was seen in a relatively high proportion of children with Chiari II malformation, suggesting that it may be associated with severe hindbrain deformity.

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Title: Periventricular nodular heterotopia is related to severity of the hindbrain deformity in Chiari II malformation
Authors: Ayako Hino-Shishikura
Tetsu Niwa
Noriko Aida
Tetsuhiko Okabe
Tomoaki Nagaoka
Jun Shibasaki
Publication date: 01-10-2012
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 10/2012
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-012-2431-1

At a glance: The STEP trials

Springer Medicine

Periventricular nodular heterotopia is related to severity of the hindbrain deformity in Chiari II malformation

Abstract

Background

Objective

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Objective

Materials and methods

Results

Conclusion

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