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Pediatric Radiology

Published in:

01-06-2008 | Original Article

Splenic nodules in paediatric Gaucher disease treated by enzyme replacement therapy

Authors: Samantha Chippington, Kieran McHugh, Ashok Vellodi

Published in: Pediatric Radiology | Issue 6/2008

Abstract

Background

The natural history of focal splenic lesions in paediatric Gaucher disease (GD) is unknown and these lesions are thought to persist despite enzyme replacement therapy (ERT).

Objective

To assess the prevalence, evolution and resolution of splenic nodules in a cohort of paediatric Gaucher patients treated with ERT.

Materials and methods

The US findings in 37 children with GD were retrospectively reviewed. A total of 28 children underwent serial abdominal US examinations as part of their initial assessment and during routine follow-up. All patients received ERT.

Results

Six children (21%) had splenic nodules on US examination, either at presentation or on follow-up examination. In all six patients, the nodules had resolved on follow-up imaging, with resolution taking 17 months to 4 years 8 months. Two sets of siblings developed nodules that resolved over a similar time period.

Conclusion

Disappearance of focal splenic lesions in children with GD during follow-up has not been previously reported. The development of new focal splenic lesions in children with GD whilst on ERT has not been previously documented.

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Title: Splenic nodules in paediatric Gaucher disease treated by enzyme replacement therapy
Authors: Samantha Chippington
Kieran McHugh
Ashok Vellodi
Publication date: 01-06-2008
Publisher: Springer-Verlag
Published in: Pediatric Radiology / Issue 6/2008
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-008-0811-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Splenic nodules in paediatric Gaucher disease treated by enzyme replacement therapy

Abstract

Background

Objective

Materials and methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Objective

Materials and methods

Results

Conclusion

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