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Published in: Pediatric Cardiology 2/2014

01-02-2014 | Review Article

Role of Endomyocardial Biopsy for Children Presenting With Acute Systolic Heart Failure

Author: Bibhuti B. Das

Published in: Pediatric Cardiology | Issue 2/2014

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Abstract

Myocarditis, an inflammatory disease of the heart, frequently results from viral infections, postviral immune-mediated responses, or both. It is a common cause of acute-onset systolic heart failure in children. Endomyocardial biopsy (EMB) remains the gold standard for the diagnosis of myocarditis. However, EMB is not performed for most myocarditis cases involving children in the United States. Clinical scenarios in which EMB results added unique prognostic data and guidance to therapy have been defined recently. This review outlines the role of EMB in the diagnosis and management of myocarditis for children presenting with acute-onset systolic heart failure.
Literature
1.
go back to reference Angelini A, Calzolaari V, Boffa GM, Maddalena F, Chioin R, Thiene G (2000) Myocarditis mimicking acute myocardial infarction: role of endomyocardial biopsy in the differential diagnosis. Heart 84:245–250PubMedCentralCrossRefPubMed Angelini A, Calzolaari V, Boffa GM, Maddalena F, Chioin R, Thiene G (2000) Myocarditis mimicking acute myocardial infarction: role of endomyocardial biopsy in the differential diagnosis. Heart 84:245–250PubMedCentralCrossRefPubMed
2.
go back to reference Aretz HT, Billingham ME, Edwards WD et al (1987) Myocarditis: a histopathological definition and classification. Am J Cardiovasc Pathol 1:3–14PubMed Aretz HT, Billingham ME, Edwards WD et al (1987) Myocarditis: a histopathological definition and classification. Am J Cardiovasc Pathol 1:3–14PubMed
3.
5.
go back to reference Breinholt JP, Moulik M, Dreyer WJ et al (2010) Viral epidemiologic shift in inflammatory heart disease: the interesting involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. J Heart Lung Transplant 29:739–746PubMedCentralCrossRefPubMed Breinholt JP, Moulik M, Dreyer WJ et al (2010) Viral epidemiologic shift in inflammatory heart disease: the interesting involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. J Heart Lung Transplant 29:739–746PubMedCentralCrossRefPubMed
6.
go back to reference Chow LH, Radio SJ, Sears TD, McManus BM (1989) Insensitivity of right ventricular endomyocardial biopsy in the diagnosis of myocarditis. J Am Coll Cardiol 14:915–920CrossRefPubMed Chow LH, Radio SJ, Sears TD, McManus BM (1989) Insensitivity of right ventricular endomyocardial biopsy in the diagnosis of myocarditis. J Am Coll Cardiol 14:915–920CrossRefPubMed
7.
go back to reference Cooper LT, Baughman KL, Feldman AM et al (2007) AHA/ACCF/ESC scientific statement: the role of endomyocardial biopsy in the management of cardiovascular disease. Circulation 50:1914–1931 Cooper LT, Baughman KL, Feldman AM et al (2007) AHA/ACCF/ESC scientific statement: the role of endomyocardial biopsy in the management of cardiovascular disease. Circulation 50:1914–1931
8.
go back to reference Crossland DS, Edmonds K, Rassl D et al (2008) Histology of explanted hearts in children transplanted for dilated cardiomyopathy. Pediatr Transplant 12:85–90CrossRefPubMed Crossland DS, Edmonds K, Rassl D et al (2008) Histology of explanted hearts in children transplanted for dilated cardiomyopathy. Pediatr Transplant 12:85–90CrossRefPubMed
9.
go back to reference Daly KP, Marshall AC, Vincent JA et al (2012) Endomyocardial biopsy and selective coronary angiography are low-risk procedures in pediatric heart transplant recipients: results of a multicenter experience. J Heart Lung Transplant 31:398–409PubMedCentralCrossRefPubMed Daly KP, Marshall AC, Vincent JA et al (2012) Endomyocardial biopsy and selective coronary angiography are low-risk procedures in pediatric heart transplant recipients: results of a multicenter experience. J Heart Lung Transplant 31:398–409PubMedCentralCrossRefPubMed
10.
go back to reference D’Ambrosio A, Patti G, Mazoli A et al (2001) The fate of acute myocarditis between spontaneous improvement and evolution to dilated cardiomyopathy: a review. Heart 85:499–504PubMedCentralCrossRefPubMed D’Ambrosio A, Patti G, Mazoli A et al (2001) The fate of acute myocarditis between spontaneous improvement and evolution to dilated cardiomyopathy: a review. Heart 85:499–504PubMedCentralCrossRefPubMed
11.
go back to reference Daubency PE, Nugent AW, Chondors P, National Australian Childhood Cardiomyopathy Study et al (2006) Clinical features and outcomes of childhood dilated cardiomyopathy: results from a national population-based study. Circulation 114:2671–2678CrossRef Daubency PE, Nugent AW, Chondors P, National Australian Childhood Cardiomyopathy Study et al (2006) Clinical features and outcomes of childhood dilated cardiomyopathy: results from a national population-based study. Circulation 114:2671–2678CrossRef
13.
go back to reference Felker GM, Boehmer JP, Hruban RH et al (2000) Echocardiographic findings in fulminant and acute myocarditis. J Am Coll Cardiol 36:227–232CrossRefPubMed Felker GM, Boehmer JP, Hruban RH et al (2000) Echocardiographic findings in fulminant and acute myocarditis. J Am Coll Cardiol 36:227–232CrossRefPubMed
14.
go back to reference Foerster SR, Canter CE, Cinar A et al (2010) Ventricular remodeling and survival are more favorable for myocarditis than for idiopathic cardiomyopathy in childhood: an outcome study from the pediatric cardiomyopathy registry. Circ Heart Fail 3:689–697CrossRefPubMed Foerster SR, Canter CE, Cinar A et al (2010) Ventricular remodeling and survival are more favorable for myocarditis than for idiopathic cardiomyopathy in childhood: an outcome study from the pediatric cardiomyopathy registry. Circ Heart Fail 3:689–697CrossRefPubMed
15.
go back to reference Friedrich MG, Sechtem U, Shulz-Menger J et al (2009) Cardiovascular magnetic resonance in myocarditis: a JACC white paper. International Sensus Group on Cardiovascular Magnetic Resonance in Myocarditis. J Am Coll Cardiol 53:1475–1487PubMedCentralCrossRefPubMed Friedrich MG, Sechtem U, Shulz-Menger J et al (2009) Cardiovascular magnetic resonance in myocarditis: a JACC white paper. International Sensus Group on Cardiovascular Magnetic Resonance in Myocarditis. J Am Coll Cardiol 53:1475–1487PubMedCentralCrossRefPubMed
16.
go back to reference Freimuth P, Philipson L, Carson SD (2008) The Coxsackie virus and adenovirus receptor. Curr Top Microbiol Immunol 323:67–87PubMed Freimuth P, Philipson L, Carson SD (2008) The Coxsackie virus and adenovirus receptor. Curr Top Microbiol Immunol 323:67–87PubMed
17.
go back to reference Frustaci A, Chimenti C, Calabrese F, Pieroni M, Thiene G, Maseri A (2003) Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunological profile of responders versus nonresponders. Circulation 107:857–863CrossRefPubMed Frustaci A, Chimenti C, Calabrese F, Pieroni M, Thiene G, Maseri A (2003) Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunological profile of responders versus nonresponders. Circulation 107:857–863CrossRefPubMed
18.
go back to reference Frustaci A, Russo MA, Chimenti C (2009) Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathies: the TIMC study. Eur Heart J 30:1995–2002CrossRefPubMed Frustaci A, Russo MA, Chimenti C (2009) Randomized study on the efficacy of immunosuppressive therapy in patients with virus-negative inflammatory cardiomyopathies: the TIMC study. Eur Heart J 30:1995–2002CrossRefPubMed
19.
go back to reference Gagliardi MG, Bevilacqua M, Di Renzi P, Picardo S, Passariello R, Marcelletti C (1991) Usefulness of magnetic resonance imaging for diagnosis of acute myocarditis in infants and children, and comparison with endomyocardial biopsy. Am J Cardiol 68:1089–1091CrossRefPubMed Gagliardi MG, Bevilacqua M, Di Renzi P, Picardo S, Passariello R, Marcelletti C (1991) Usefulness of magnetic resonance imaging for diagnosis of acute myocarditis in infants and children, and comparison with endomyocardial biopsy. Am J Cardiol 68:1089–1091CrossRefPubMed
20.
go back to reference Hauck AJ, Kearney DL, Edwards WD (1989) Evaluation of postmortem endomyocardial biopsy specimens from 38 patients with lymphocytic myocarditis: implications for the role of sampling error. Mayo Clin Proc 64:1235–1245CrossRefPubMed Hauck AJ, Kearney DL, Edwards WD (1989) Evaluation of postmortem endomyocardial biopsy specimens from 38 patients with lymphocytic myocarditis: implications for the role of sampling error. Mayo Clin Proc 64:1235–1245CrossRefPubMed
21.
go back to reference Hill KD, Atkinson JB, Doyle TP, Dodd D (2009) Routine performance of endomyocardial biopsy decreases the incidence of orthotopic heart transplant for myocarditis. J Heart Lung Transplant 26:1261–1266CrossRef Hill KD, Atkinson JB, Doyle TP, Dodd D (2009) Routine performance of endomyocardial biopsy decreases the incidence of orthotopic heart transplant for myocarditis. J Heart Lung Transplant 26:1261–1266CrossRef
22.
go back to reference Jessup M, Abraham WT, Casey DE et al (2009) 2009 Focused Update: ACCF/AHA guidelines for the diagnosis and management of heart failure in adults: a report of the ACCCF/AHA Task Force on Practice Guidelines: Developed in Collaboration with ISHLT. Circulation 119:1977–2016CrossRefPubMed Jessup M, Abraham WT, Casey DE et al (2009) 2009 Focused Update: ACCF/AHA guidelines for the diagnosis and management of heart failure in adults: a report of the ACCCF/AHA Task Force on Practice Guidelines: Developed in Collaboration with ISHLT. Circulation 119:1977–2016CrossRefPubMed
23.
go back to reference Kinderman I, Kinderman M, Kandolf R et al (2008) Predictors of outcome in patients with suspected myocarditis. Circulation 118:639–648CrossRef Kinderman I, Kinderman M, Kandolf R et al (2008) Predictors of outcome in patients with suspected myocarditis. Circulation 118:639–648CrossRef
24.
go back to reference Kuhl U, Lauer B, Souvatzoglu M, Vosberg H, Schultheiss HP (1998) Antimyosin scintigraphy and immunohistologic analysis of endomyocardial biopsy in patients with clinically suspected myocarditis evidence of myocardial cell damage and inflammation in the absence of histological signs of myocarditis. J Am Coll Cardiol 32:1371–1376CrossRefPubMed Kuhl U, Lauer B, Souvatzoglu M, Vosberg H, Schultheiss HP (1998) Antimyosin scintigraphy and immunohistologic analysis of endomyocardial biopsy in patients with clinically suspected myocarditis evidence of myocardial cell damage and inflammation in the absence of histological signs of myocarditis. J Am Coll Cardiol 32:1371–1376CrossRefPubMed
26.
go back to reference Lie JT (1988) Myocarditis and endomyocardial biopsy in unexplained heart failure: a diagnosis in search of a disease (editorial). Ann Intern Med 109:525–528CrossRefPubMed Lie JT (1988) Myocarditis and endomyocardial biopsy in unexplained heart failure: a diagnosis in search of a disease (editorial). Ann Intern Med 109:525–528CrossRefPubMed
27.
28.
go back to reference Martin AB, Webber S, Fricker FJ et al (1994) Acute myocarditis: rapid diagnosis by PCR in children. Circulation 90:330–339CrossRefPubMed Martin AB, Webber S, Fricker FJ et al (1994) Acute myocarditis: rapid diagnosis by PCR in children. Circulation 90:330–339CrossRefPubMed
29.
go back to reference Mason JW, O’Connell JB, Herskowtiz A et al (1995) A clinical trial of immunosuppressive therapy for myocarditis: the myocarditis treatment trial investigators. N Engl J Med 333:269–275CrossRefPubMed Mason JW, O’Connell JB, Herskowtiz A et al (1995) A clinical trial of immunosuppressive therapy for myocarditis: the myocarditis treatment trial investigators. N Engl J Med 333:269–275CrossRefPubMed
30.
go back to reference McNamara DM, Holubkov R, Starling RC et al (2001) Controlled trial of intravenous immune globulin in recent-onset cardiomyopathy. Circulation 103:2254–2259CrossRefPubMed McNamara DM, Holubkov R, Starling RC et al (2001) Controlled trial of intravenous immune globulin in recent-onset cardiomyopathy. Circulation 103:2254–2259CrossRefPubMed
31.
go back to reference Mendes LA, Dec GW, Picard MH, Palacios IF, Newell J, Davidoff R (1994) Right ventricular dysfunction: an independent predictor of adverse outcome in patients with myocarditis. Am Heart J 128:301–307CrossRefPubMed Mendes LA, Dec GW, Picard MH, Palacios IF, Newell J, Davidoff R (1994) Right ventricular dysfunction: an independent predictor of adverse outcome in patients with myocarditis. Am Heart J 128:301–307CrossRefPubMed
32.
go back to reference Pietra BA, Kantor PF, Bartlett HL et al (2012) Early predictors of survival to and after heart transplantation in children with dilated cardiomyopathy. Circulation 126:1079–1086PubMedCentralCrossRefPubMed Pietra BA, Kantor PF, Bartlett HL et al (2012) Early predictors of survival to and after heart transplantation in children with dilated cardiomyopathy. Circulation 126:1079–1086PubMedCentralCrossRefPubMed
33.
go back to reference Pophal SG, Sigfusson G, Booth KL et al (1999) Complications of endomyocardial biopsy in children. J Am Coll Cardiol 34:2105–2110CrossRefPubMed Pophal SG, Sigfusson G, Booth KL et al (1999) Complications of endomyocardial biopsy in children. J Am Coll Cardiol 34:2105–2110CrossRefPubMed
34.
go back to reference Richardson P, McKenna W, Bristow M et al (1996) Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of Cardiomyopathies. Circulation 93:841–842CrossRefPubMed Richardson P, McKenna W, Bristow M et al (1996) Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of Cardiomyopathies. Circulation 93:841–842CrossRefPubMed
35.
go back to reference Schmaltz AA, Apitz J, Hort W, Maisch B (1990) Endomyocardial biopsy in infants and children: experience in 60 patients. Pediatr Cardiol 11:15–21CrossRefPubMed Schmaltz AA, Apitz J, Hort W, Maisch B (1990) Endomyocardial biopsy in infants and children: experience in 60 patients. Pediatr Cardiol 11:15–21CrossRefPubMed
37.
go back to reference Stanton C, Mookadam F, Cha S et al (2008) Greater symptom duration predicts response to immunomodulatory therapy in dilated cardiomyopathy. Int J Cardiol 128:38–41CrossRefPubMed Stanton C, Mookadam F, Cha S et al (2008) Greater symptom duration predicts response to immunomodulatory therapy in dilated cardiomyopathy. Int J Cardiol 128:38–41CrossRefPubMed
38.
go back to reference Wojnicz R, Nowalany-Kozielska E, Wojciechowska C et al (2001) Randomized, placebo-controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy: two-year follow-up results. Circulation 104:39–45CrossRefPubMed Wojnicz R, Nowalany-Kozielska E, Wojciechowska C et al (2001) Randomized, placebo-controlled study for immunosuppressive treatment of inflammatory dilated cardiomyopathy: two-year follow-up results. Circulation 104:39–45CrossRefPubMed
Metadata
Title
Role of Endomyocardial Biopsy for Children Presenting With Acute Systolic Heart Failure
Author
Bibhuti B. Das
Publication date
01-02-2014
Publisher
Springer US
Published in
Pediatric Cardiology / Issue 2/2014
Print ISSN: 0172-0643
Electronic ISSN: 1432-1971
DOI
https://doi.org/10.1007/s00246-013-0807-0

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