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Published in:

01-11-2009 | Original Article

Synergistic Effects of Elevated Systolic Blood Pressure and Hypercholesterolemia on Carotid Intima–Media Thickness in Children and Adolescents

Authors: Andreas Krebs, Arno Schmidt-Trucksäss, Janine Alt, Jürgen Doerfer, Kristin Krebs, Karl Winkler, Karl Otfried Schwab

Published in: Pediatric Cardiology | Issue 8/2009

Abstract

This study aimed to investigate the synergistic effects of elevated systolic blood pressure (SBP) and hypercholesterolemia on carotid intima–media thickness (cIMT). For this study, 60 children with hypercholesterolemia and 40 healthy control children were divided into four subgroups: hypercholesterolemic children with normal (<90th percentile) or elevated (≥90th percentile) SBP and control children with normal or elevated SBP. The highest mean and maximal cIMT values were found in the hypercholesterolemic children with elevated SBP and were significantly different from those of all the other groups. The synergistic effects of elevated SBP and hypercholesterolemia lead to a significant increase in cIMT as a subclinical sign of early atherosclerosis.

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Title: Synergistic Effects of Elevated Systolic Blood Pressure and Hypercholesterolemia on Carotid Intima–Media Thickness in Children and Adolescents
Authors: Andreas Krebs
Arno Schmidt-Trucksäss
Janine Alt
Jürgen Doerfer
Kristin Krebs
Karl Winkler
Karl Otfried Schwab
Publication date: 01-11-2009
Publisher: Springer-Verlag
Published in: Pediatric Cardiology / Issue 8/2009
Print ISSN: 0172-0643
Electronic ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-009-9510-6

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Synergistic Effects of Elevated Systolic Blood Pressure and Hypercholesterolemia on Carotid Intima–Media Thickness in Children and Adolescents

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