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01-07-2009 | Riley Symposium

Analysis of Ventricular Hypertrabeculation and Noncompaction Using Genetically Engineered Mouse Models

Authors: Hanying Chen, Wenjun Zhang, Deqiang Li, Tim M. Cordes, R. Mark Payne, Weinian Shou

Published in: Pediatric Cardiology | Issue 5/2009

Abstract

Ventricular trabeculation and compaction are two of the many essential steps for generating a functionally competent ventricular wall. A significant reduction in trabeculation is usually associated with ventricular compact zone deficiencies (hypoplastic wall), which commonly lead to embryonic heart failure and early embryonic lethality. In contrast, hypertrabeculation and lack of ventricular wall compaction (noncompaction) are closely related defects in cardiac embryogenesis associated with left ventricular noncompaction, a genetically heterogeneous disorder. Here we summarize our recent findings through the analyses of several genetically engineered mouse models that have defects in cardiac trabeculation and compaction. Our data indicate that cellular growth and differentiation signaling pathways are keys in these ventricular morphogenetic events.

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Title: Analysis of Ventricular Hypertrabeculation and Noncompaction Using Genetically Engineered Mouse Models
Authors: Hanying Chen
Wenjun Zhang
Deqiang Li
Tim M. Cordes
R. Mark Payne
Weinian Shou
Publication date: 01-07-2009
Publisher: Springer-Verlag
Published in: Pediatric Cardiology / Issue 5/2009
Print ISSN: 0172-0643
Electronic ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-009-9406-5

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