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Open Access 01-07-2009 | Riley Symposium

Cardiac Tissue Engineering: Implications for Pediatric Heart Surgery

Authors: Wolfram-Hubertus Zimmermann, Robert Cesnjevar

Published in: Pediatric Cardiology | Issue 5/2009

Abstract

Children with severe congenital malformations, such as single-ventricle anomalies, have a daunting prognosis. Heart transplantation would be a therapeutic option but is restricted due to a lack of suitable donor organs and, even in case of successful heart transplantation, lifelong immune suppression would frequently be associated with a number of serious side effects. As an alternative to heart transplantation and classical cardiac reconstructive surgery, tissue-engineered myocardium might become available to augment hypomorphic hearts and/or provide new muscle material for complex myocardial reconstruction. These potential applications of tissue engineered myocardium will, however, impose major challenges to cardiac tissue engineers as well as heart surgeons. This review will provide an overview of available cardiac tissue-engineering technologies, discuss limitations, and speculate on a potential application of tissue-engineered heart muscle in pediatric heart surgery.

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Title: Cardiac Tissue Engineering: Implications for Pediatric Heart Surgery
Authors: Wolfram-Hubertus Zimmermann
Robert Cesnjevar
Publication date: 01-07-2009
Publisher: Springer-Verlag
Published in: Pediatric Cardiology / Issue 5/2009
Print ISSN: 0172-0643
Electronic ISSN: 1432-1971
DOI: https://doi.org/10.1007/s00246-009-9405-6

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