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Urolithiasis
Published in: Urolithiasis 1/2011

01-02-2011 | Original Paper

Combining gastric and ileal segments, does it overcome segment-related complications? An experimental study on rats

Authors: Berk Burgu, Mehmet İlker Gökce, Özgü Aydoğdu, Evren Süer, Duygu Kankaya, Tarkan Soygür

Published in: Urolithiasis | Issue 1/2011

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Abstract

Bladder augmentation has revolutionized the care of children with neurogenic bladder but it is associated with certain short- and long-term complications. Using the combination of gastric and ileal segments to balance effects of these segments might be a solution for complications. A total of 39 female Spraque-Dawley rats randomly divided into four groups: ileocystoplasty (11), gastrocystoplasty (9), ileogastrocystoplasty (11) and control (8). Serum/urine electrolytes and pH values, and serum creatinine levels and urine mucus concentration were measured. Kruskal–Wallis non-parametric variance analysis was performed to compare the groups and p < 0.05 was accepted as significant. Metabolic alkalosis with significantly lower urine pH was observed in gastrocystoplasty group. Gastroileal group showed similar results with the ileal group in all parameters. No stone formation was detected in the sham and gastric cystoplasty groups. Metaplastic and hyperplastic changes were observed in all segments surrounding urothelium. In conclusion, combination of gastric and ileal segments does not significantly reduce the rate of metabolic impairments, stone and mucus formation. Besides it is not associated with significant improvement in histological outcome since urine is still in contact with the gastrointestinal mucosa.
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Metadata
Title
Combining gastric and ileal segments, does it overcome segment-related complications? An experimental study on rats
Authors
Berk Burgu
Mehmet İlker Gökce
Özgü Aydoğdu
Evren Süer
Duygu Kankaya
Tarkan Soygür
Publication date
01-02-2011
Publisher
Springer-Verlag
Published in
Urolithiasis / Issue 1/2011
Print ISSN: 2194-7228
Electronic ISSN: 2194-7236
DOI
https://doi.org/10.1007/s00240-010-0283-4

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