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European Journal of Plastic Surgery
Published in: European Journal of Plastic Surgery 5/2020

01-10-2020 | Skin Graft | Original Paper

The effect of local insulin injection on the healing process of split thickness skin graft donor site: a randomized, double-blind, placebo control clinical trial

Authors: Shahriar Haddady Abianeh, Sohrab Moradi Bajestani, Javad Rahmati, Mohammad Amin Shahrbaf, Nooshin Shirzad

Published in: European Journal of Plastic Surgery | Issue 5/2020

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Abstract

Background

Wound site coverage by a split-thickness skin graft (STSG) is an effective technique after reconstructive surgery. Previous studies have been suggested that insulin is a stimulator for skin wound healing. This study was aimed to determine the effect of local insulin injection on the improvement of STSG donor site wound healing.

Methods

A randomized clinical trial was performed in patients undergoing STSG in 2019. The donor site of patients was divided into control and case segments. Two cubic centimeters of NPH insulin was injected at the case segment with a concentration of 1 IU/ml and normal saline was injected at the control segment by the same volume. The wound site epithelialization area was calculated by ImageJ® software at the 7th, 14th, and the 21st day after the intervention. The epithelialization area of the case and control group was compared by SPSS software.

Results

Epithelialization area was improved at the 21st day compared to 14th day and 7th day. In addition, the amount of epithelialization was significantly higher at the case segment in the 7th, 14th, and the 21st day after the injection with the P values of 0.006, 0.001, and < 0.0001, respectively. Moreover, there was not any sign of hypoglycemia and other complications in patients.

Conclusion

Subdermal injection of insulin may improve the wound site epithelialization in the post-operative period.
Level of evidence: Level I, therapeutic study.
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Metadata
Title
The effect of local insulin injection on the healing process of split thickness skin graft donor site: a randomized, double-blind, placebo control clinical trial
Authors
Shahriar Haddady Abianeh
Sohrab Moradi Bajestani
Javad Rahmati
Mohammad Amin Shahrbaf
Nooshin Shirzad
Publication date
01-10-2020
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Plastic Surgery / Issue 5/2020
Print ISSN: 0930-343X
Electronic ISSN: 1435-0130
DOI
https://doi.org/10.1007/s00238-020-01683-3

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