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01-09-2021 | Hematoma | Short Report

Association between perihematomal perfusion and intracerebral hemorrhage shape

Published in: Neuroradiology | Issue 9/2021

Abstract

Purpose

The pathophysiological determinants of irregular intracerebral hemorrhage (ICH) shape are unclear. We aimed at characterizing the relationship between perihematomal perfusion and ICH shape.

Methods

A single-center cohort of patients with primary ICH was analyzed. Patients underwent computed tomography perfusion within 6 h from onset. Cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) were calculated in the manually outlined perihematomal low-density region. ICH shape was rated on baseline non-contrast CT following international consensus criteria, and predictors of irregular shape were explored with logistic regression.

Results

A total of 150 patients were included, of whom 66 (44%) had irregular shape. Perihematomal CBF was lower in irregular ICH (median 23 vs 35 mL/100 g/min, p<0.001). CBF<20 mL/100 g/min was independently associated with irregular shape (odds ratio 9.67, 95% CI 2.42–38.69, p=0.001).

Conclusion

Our findings suggest that perihematomal hypoperfusion may contribute to the CT appearance of acute ICH.

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Title: Association between perihematomal perfusion and intracerebral hemorrhage shape
Publication date: 01-09-2021
Keywords: Hematoma
Edema
Published in: Neuroradiology / Issue 9/2021
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-021-02709-8

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Association between perihematomal perfusion and intracerebral hemorrhage shape

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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