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Neuroradiology
Published in: Neuroradiology 1/2018

01-01-2018 | Diagnostic Neuroradiology

Differentiation of grade II/III and grade IV glioma by combining “T1 contrast-enhanced brain perfusion imaging” and susceptibility-weighted quantitative imaging

Authors: Jitender Saini, Pradeep Kumar Gupta, Prativa Sahoo, Anup Singh, Rana Patir, Suneeta Ahlawat, Manish Beniwal, K. Thennarasu, Vani Santosh, Rakesh Kumar Gupta

Published in: Neuroradiology | Issue 1/2018

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Abstract

Purpose

MRI is a useful method for discriminating low- and high-grade glioma using perfusion MRI and susceptibility-weighted imaging (SWI). The purpose of this study is to evaluate the usefulness of T1-perfusion MRI and SWI in discriminating among grade II, III, and IV gliomas.

Methods

T1-perfusion MRI was used to measure relative cerebral blood volume (rCBV) in 129 patients with glioma (70 grade IV, 33 grade III, and 26 grade II tumors). SWI was also used to measure the intratumoral susceptibility signal intensity (ITSS) scores for each tumor in these patients. rCBV and ITSS values were compared to seek differences between grade II vs. grade III, grade III vs. grade IV, and grade III+II vs. grade IV tumors.

Results

Significant differences in rCBV values of the three grades of the tumors were noted and pairwise comparisons showed significantly higher rCBV values in grade IV tumors as compared to grade III tumors, and similarly increased rCBV was seen in the grade III tumors as compared to grade II tumors (p < 0.001). Grade IV gliomas showed significantly higher ITSS scores on SWI as compared to grade III tumors (p < 0.001) whereas insignificant difference was seen on comparing ITSS scores of grade III with grade II tumors. Combining the rCBV and ITSS resulted in significant improvement in the discrimination of grade III from grade IV tumors.

Conclusion

The combination of rCBV values derived from T1-perfusion MRI and SWI derived ITSS scores improves the diagnostic accuracy for discrimination of grade III from grade IV gliomas.
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Metadata
Title
Differentiation of grade II/III and grade IV glioma by combining “T1 contrast-enhanced brain perfusion imaging” and susceptibility-weighted quantitative imaging
Authors
Jitender Saini
Pradeep Kumar Gupta
Prativa Sahoo
Anup Singh
Rana Patir
Suneeta Ahlawat
Manish Beniwal
K. Thennarasu
Vani Santosh
Rakesh Kumar Gupta
Publication date
01-01-2018
Publisher
Springer Berlin Heidelberg
Published in
Neuroradiology / Issue 1/2018
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-017-1942-8

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