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01-05-2013 | Diagnostic Neuroradiology

Utility of multiparametric 3-T MRI for glioma characterization

Authors: Bhaswati Roy, Rakesh K. Gupta, Andrew A. Maudsley, Rishi Awasthi, Sulaiman Sheriff, Meng Gu, Nuzhat Husain, Sudipta Mohakud, Sanjay Behari, Chandra M. Pandey, Ram K. S. Rathore, Daniel M. Spielman, Jeffry R. Alger

Published in: Neuroradiology | Issue 5/2013

Abstract

Introduction

Accurate grading of cerebral glioma using conventional structural imaging techniques remains challenging due to the relatively poor sensitivity and specificity of these methods. The purpose of this study was to evaluate the relative sensitivity and specificity of structural magnetic resonance imaging and MR measurements of perfusion, diffusion, and whole-brain spectroscopic parameters for glioma grading.

Methods

Fifty-six patients with radiologically suspected untreated glioma were studied with T1- and T2-weighted MR imaging, dynamic contrast-enhanced MR imaging, diffusion tensor imaging, and volumetric whole-brain MR spectroscopic imaging. Receiver-operating characteristic analysis was performed using the relative cerebral blood volume (rCBV), apparent diffusion coefficient, fractional anisotropy, and multiple spectroscopic parameters to determine optimum thresholds for tumor grading and to obtain the sensitivity, specificity, and positive and negative predictive values for identifying high-grade gliomas. Logistic regression was performed to analyze all the parameters together.

Results

The rCBV individually classified glioma as low and high grade with a sensitivity and specificity of 100 and 88 %, respectively, based on a threshold value of 3.34. On combining all parameters under consideration, the classification was achieved with 2 % error and sensitivity and specificity of 100 and 96 %, respectively.

Conclusion

Individually, CBV measurement provides the greatest diagnostic performance for predicting glioma grade; however, the most accurate classification can be achieved by combining all of the imaging parameters.

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Title: Utility of multiparametric 3-T MRI for glioma characterization
Authors: Bhaswati Roy
Rakesh K. Gupta
Andrew A. Maudsley
Rishi Awasthi
Sulaiman Sheriff
Meng Gu
Nuzhat Husain
Sudipta Mohakud
Sanjay Behari
Chandra M. Pandey
Ram K. S. Rathore
Daniel M. Spielman
Jeffry R. Alger
Publication date: 01-05-2013
Publisher: Springer-Verlag
Published in: Neuroradiology / Issue 5/2013
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-013-1145-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Utility of multiparametric 3-T MRI for glioma characterization

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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