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Neuroradiology
Published in: Neuroradiology 11/2011

01-11-2011 | Diagnostic Neuroradiology

Cortical thickness, gray matter volume, and white matter anisotropy and diffusivity in schizophrenia

Authors: Mizuho Murakami, Hidemasa Takao, Osamu Abe, Hidenori Yamasue, Hiroki Sasaki, Wataru Gonoi, Yosuke Takano, Kunio Takei, Kiyoto Kasai, Kuni Ohtomo

Published in: Neuroradiology | Issue 11/2011

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Abstract

Introduction

The study was conducted to evaluate simultaneously gray matter changes and white matter changes in patients with schizophrenia.

Methods

Cortical thickness, gray matter volume, and white matter anisotropy and diffusivity changes in schizophrenic patients (n = 21) were assessed relative to age-, gender-, and parental socioeconomic status-matched healthy controls (n = 21). We used a newly described semi-automated method (FreeSurfer version 4.5) to determine cortical thickness and gray matter volume and used the tract-based spatial statistics method to evaluate white matter anisotropy and diffusivity.

Results

Schizophrenic patients showed a significant decrease in hippocampal volume compared with healthy controls. No significant thickness deficits or anisotropy and diffusivity changes were found in schizophrenic patients compared with healthy controls. Stepwise multivariate analysis revealed that hippocampal volume was positively related to duration of illness in schizophrenic patients.

Conclusion

Our results suggest that hippocampal volume is smaller in schizophrenic patients compared with healthy controls and that progressive hippocampal volume loss occurs in the early course of illness in schizophrenic patients but not in the more chronic stages.
Literature
1.
Hulshoff Pol HE, Schnack HG, Bertens MG, van Haren NE, van der Tweel I, Staal WG, Baare WF, Kahn RS (2002) Volume changes in gray matter in patients with schizophrenia. Am J Psychiatry 159(2):244–250PubMedCrossRef
2.
Hulshoff Pol HE, Kahn RS (2008) What happens after the first episode? A review of progressive brain changes in chronically ill patients with schizophrenia. Schizophr Bull 34(2):354–366PubMedCrossRef
3.
Schultz CC, Koch K, Wagner G, Roebel M, Schachtzabel C, Gaser C, Nenadic I, Reichenbach JR, Sauer H, Scholosser RG (2010) Reduced cortical thickness in first episode schizophrenia. Schizophr Res 116(2–3):204–209PubMedCrossRef
4.
Crespo-Facorro B, Roiz-Santianez R, Perez-lglesias R, Tordesillas-Gutierrez D, Rodriguez-Sanchez JM, de Lucas EM, Vazquez-Barquero JL (2009) Specific brain structural abnormalities in first-episode schizophrenia. A comparative study with patients with schizophreniform disorder, non-schizophrenic non-affective psychoses and healthy volunteers. Schizophr Res 115(2–3):191–201PubMedCrossRef
5.
Fornito A, Yucel M, Patti J, Wood SJ, Pantelis C (2009) Mapping grey matter reductions in schizophrenia: an anatomical likelihood estimation analysis of voxel-based morphometry studies. Schizophr Res 108(1–3):104–113PubMedCrossRef
6.
Chan WY, Chia MY, Yang GL, Woon PS, Sitoh YY, Collinson SL, Nowinski WL, Sim K (2009) Duration of illness, regional brain morphology and neurocognitive correlates in schizophrenia. Ann Acad Med Singapore 38(5):388–395PubMed
7.
Bose SK, Mackinnon T, Mehta MA, Turkheimer FE, Howes OD, Selvaraj S, Kempton MJ, Grasby PM (2009) The effect of ageing on grey and white matter reductions in schizophrenia. Schizophr Res 112(1–3):7–13PubMedCrossRef
8.
Goldman AL, Pezawas L, Mattay VS, Fischl B, Verchinski BA, Chen Q, Weinberger DR, Meyer-Lindenberg A (2009) Widespread reductions of cortical thickness in schizophrenia and spectrum disorders and evidence of heritability. Arch Gen Psychiatry 66(5):467–477PubMedCrossRef
9.
Jaaro-Peled H, Ayhan Y, Plentnikov MV, Sawa A (2010) Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models. Schizophr Bull 36(2):301–313PubMedCrossRef
10.
Harrison PJ (1999) The neuropathology of schizophrenia. A critical review data and their interpretation. Brain 122(4):596–624CrossRef
11.
McDonald C, Bullmore ET, Sham PC, Chitnis X, Wickham H, Bramon E, Murray RM (2004) Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes. Arch Gen Psychiatry 61(10):974–984PubMedCrossRef
12.
Wright IC, Rabe-Hesketh S, Woodruff PW, David AS, Murray RM, Bullmore ET (2000) Meta-analysis of regional brain volumes in schizophrenia. Am J Psychiatry 157(1):16–25PubMed
13.
Walder DJ, Seidman LJ, Cullen N, Su J, Tsuang MT, Goldstein JM (2006) Sex differences in language dysfunction in schizophrenia. Am J Psychiatry 163(3):470–477PubMedCrossRef
14.
Walder DJ, Seidman LJ, Makris N, Tsuang MT, Kennedy DN, Goldstein JM (2007) Neuroanatomic substrates of sex differences in language dysfunction in schizophrenia: a pilot study. Schizophr Res 90(1–3):295–301PubMedCrossRef
15.
Narr KL, Bilder RM, Toga AW, Woods RP, Rex DE, Szeszko PR, Robinson D, Sevy S, Gunduz-Bruce H, Wang YP, DeLuca H, Thompson PM (2005) Mapping cortical thickness and gray matter concentration in first episode schizophrenia. Cereb Cortex 15(6):708–719PubMedCrossRef
16.
Nugent TF 3rd, Herman DH, Ordonez A, Greenstein D, Hayashi KM, Lenane M, Clasen L, Jung D, Toga AW, Giedd JN, Rapoport JL, Thompson PM, Gogtay N (2007) Dynamic mapping of hippocampal development in childhood onset schizophrenia. Schizophr Res 90(1–3):62–70PubMedCrossRef
17.
Glenthoj A, Glenthoj BY, Mackeprang T, Pagsberg AK, Hemmingsen RP, Jernigan TL, Baare WF (2007) Basal ganglia volumes in drug-naive first-episode schizophrenia patients before and after short-term treatment with either a typical or an atypical antipsychotic drug. Psychiatry Res 154(3):199–208PubMedCrossRef
18.
Lang DJ, Kopala LC, Vandorpe RA, Rui Q, Smith GN, Goghari VM, Lapointe JS, Horner WG (2004) Reduced basal ganglia volumes after switching to olanzapine in chronically treated patients with schizophrenia. Am J Psychiatry 161(10):1829–1836PubMedCrossRef
19.
Gur RE, Maany V, Mozley PD, Swanson C, Biker W, Gur RC (1998) Subcortical MRI volumes in neuroleptic-naive and treated patients with schizophrenia. Am J Psychiatry 155(12):1711–1717PubMed
20.
McClure RK, Phillips I, Jazayerli R, Barnett A, Coppola R, Weinberger DR (2006) Regional change in brain morphometry in schizophrenia associated with antipsychotic treatment. Psychiatry Res 148(2):121–132PubMedCrossRef
21.
Khorram B, Lang DJ, Kopala LC, Vandorpe RA, Rui Q, Goghari VM, Smith GN, Horner WG (2006) Reduced thalamic volume in patients with chronic schizophrenia after switching from typical antipsychotic medications to olanzapine. Am J Psychiatry 163(11):2005–2007PubMedCrossRef
22.
Buchsbaum MS, Friedman J, Buchsbaum BR, Chu KW, Hazlett EA, Newmark R, Schneiderman JS, Torosjan Y, Tang C, Hof PR, Stewart D, Davis KL, Gorman J (2006) Diffusion tensor imaging in schizophrenia. Biol Psychiatry 60(11):1181–1187PubMedCrossRef
23.
Kubicki M, McCarley R, Westin CF, Park HJ, Maier S, Kikinis R, Jolesz FA, Shenton ME (2007) A review of diffusion tensor imaging studies in schizophrenia. J Psychiatr Res 41(1–2):15–30PubMedCrossRef
24.
Kanaan RA, Kim JS, Kaufmann WE, Pearlson GD, Barker GJ, McGuire PK (2005) Diffusion tensor imaging in schizophrenia. Biol Psychiatry 58(12):921–929PubMedCrossRef
25.
Miyata J, Hirao K, Namiki C, Fujiwara H, Shimizu M, Fukuyama H, Sawamoto N, Hayashi T, Murai T (2009) Reduced white matter integrity correlated with cortico-subcortical gray matter deficits in schizophrenia. Schizophr Res 111(1–3):78–85PubMedCrossRef
26.
Floresco SB, Zhang Y, Enomoto T (2009) Neural circuits subserving behavioral flexibility and their relevance to schizophrenia. Behav Brain Res 204(2):396–409PubMedCrossRef
27.
Jones MW (2010) Errant ensembles: dysfunctional neuronal network dynamics in schizophrenia. Biochem Soc Trans 38(2):516–21PubMedCrossRef
28.
Shenton ME, Dickey CC, Frumin M, McCarley RW (2001) A review of MRI findings in schizophrenia. Schizophr Res 49(1–2):1–52PubMedCrossRef
29.
Jovicich J, Czanner S, Greve D, Haley E, van der Kouwe A, Gollub R, Kennedy D, Schmitt F, Brown G, Macfall J, Fischl B, Dale AM (2006) Reliability in multi-site structural MRI studies: effects of gradient non-linearity correction on phantom and human data. Neuroimage 30(2):436–443PubMedCrossRef
30.
Sereno MI, Dale AM, Reppas JB, Kwong KK, Belliveau JW, Brady TF, Rosen BR, Tootel RB (1995) Borders of multiple visual areas in humans revealed by functional magnetic resonance imaging. Science 268(5212):889–893PubMedCrossRef
31.
Dale AM, Fischl B, Sereno MI (1999) Cortical surface-based analysis. I. Segmentation surface reconstruction. Neuroimage 9(2):179–194PubMedCrossRef
32.
Fischl B, Sereno MI, Dale AM (1999) Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. Neuroimage 9(2):195–207PubMedCrossRef
33.
Fischl B, Sereno MI, Tootell RB, Dale AM (1999) High-resolution intersubject averaging and a coordinate system for the cortical surface. Hum Brain Mapp 8(4):272–284PubMedCrossRef
34.
Fischl B, Dale AM (2000) Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci USA 97(20):11050–11055PubMedCrossRef
35.
Salat DH, Buckner RL, Snyder AZ, Greve DN, Desikan RS, Busa E, Morris JC, Dale AM, Fischl B (2004) Thinning of the cerebral cortex in aging. Cereb Cortex 14(7):721–730PubMedCrossRef
36.
Segonne F, Dale AM, Busa E, Glessner M, Salat D, Hahn HK, Fischl B (2004) A hybrid approach to the skull stripping problem in MRI. Neuroimage 22(3):1060–1075PubMedCrossRef
37.
Segonne F, Grimson E, Fischl B (2005) A genetic algorithm for the topology correction of cortical surfaces. Inf Process Med Imaging 19:393–405PubMedCrossRef
38.
Rosas HD, Liu AK, Hersch S, Glessner M, Ferrante RJ, Salat DH, van der Kouwe A, Jenkins BG, Dale AM, Fischl B (2002) Regional and progressive thinning of the cortical ribbon in Huntington's disease. Neurology 58(5):695–701PubMed
39.
Kuperberg GR, Broome MR, McGuire PK, David AS, Eddy M, Ozawa F, West WC, Williams SC, van der Kouwe AJ, Salat DH, Dale AM, Fischl B (2003) Regionally localized thinning of the cerebral cortex in schizophrenia. Arch Gen Psychiatry 60(9):878–888PubMedCrossRef
40.
Takao H, Abe O, Ohtomo K (2010) Computational analysis of cerebral cortex. Neuroradiology 52(8):691–8PubMedCrossRef
41.
Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van der Kouwe A, Killiany R, Kennedy D, Klaveness S, Montillo A, Makris N, Rosen B, Dale AM (2002) Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33(3):341–355PubMedCrossRef
42.
Tae WS, Kim SS, Lee KU, Nam EC, Kim KW (2008) Validation of hippocampal volumes measured using a manual method and two automated methods (FreeSurfer and IBASPM) in chronic major depressive disorder. Neuroradiology 50(7):569–581PubMedCrossRef
43.
Smith SM, Jenkinson M, Johansen-Berg H, Rueckert D, Nichols TE, Mackay CE, Watkins KE, Ciccarelli O, Cader MZ, Matthews PM, Behrens TE (2006) Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 31(4):1487–1505PubMedCrossRef
44.
Smith SM, Johansen-Berg H, Jenkinson M, Rueckert D, Nichols TE, Miller KL, Robson MD, Jones DK, Klein JC, Bartsch AJ, Behrens TE (2007) Acquisition and voxelwise analysis of multi-subject diffusion data with tract-based spatial statistics. Nat Protoc 2(3):499–503PubMedCrossRef
45.
Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H, Bannister PR, De Luca M, Drobnjak I, Flitney DE, Niazy RK, Saunders J, Vickers J, Zhang Y, De Stefano N, Brady JM, Matthews PM (2004) Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23(Suppl 1):S208–219PubMedCrossRef
46.
Abe O, Takao H, Gonoi W, Sasaki H, Murakami M, Kabasawa H, Kawaguchi H, Goto M, Yamada H, Yamasue H, Kasai K, Aoki S, Ohtomo K (2010) Voxel-based analysis of the diffusion tensor. Neuroradiology 52(8):699–710PubMedCrossRef
47.
48.
Nichols TE, Holmes AP (2002) Nonparametric permutation tests for functional neuroimaging: a primer with examples. Hum Brain Mapp 15(1):1–25PubMedCrossRef
49.
Mikell CB, McKhann GM, Segal S, McGovern RA, Wallenstein MB, Moore H (2009) The hippocampus and nucleus accumbens as potential therapeutic targets for neurosurgical intervention in schizophrenia. Stereotact Funct Neurosurg 87(4):256–265PubMedCrossRef
50.
Freedman R, Goldowitz D (2010) Studies on the hippocampal formation: from basic development to clinical applications: studies on schizophrenia. Prog Neurobiol 90(2):263–275PubMedCrossRef
51.
Steen RF, Mull C, McClure R, Lieberman JA (2006) Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies. Br J Psychiatry 188:510–518PubMedCrossRef
52.
Vita A, De Peri L, Silenzi C, Dieci M (2006) Brain morphology in first-episode schizophrenia: a meta-analysis of quantitative magnetic resonance imaging studies. Schizophr Res 82(1):75–88PubMedCrossRef
53.
Koolschijin PC, van Haren NE, Cahn W, Schnack HG, Janssen J, Klumpers F, Hulshoff Pol HE, Kahn RS (2010) Hippocampal volume change in schizophrenia. J Clin Psychiatry 71(6):737–744CrossRef
54.
Buehlmann E, Berger GE, Aston J, Gschwandtner U, Pflueger MO, Borgwardt SJ, Radue EW, Riecher-Rossler A (2010) Hippocampus abnormalities in at risk mental states for psychosis? A cross-sectional high resolution region of interest magnetic resonance imaging study. J Psychiatr Res 44(7):447–453PubMedCrossRef
55.
Chakos MH, Schobel SA, Gu H, Gerig G, Bradford D, Charles C, Lieberman JA (2005) Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia. Br J Psychiatry 186:26–31PubMedCrossRef
56.
Smieskova R, Fusar-Poli P, Allen P, Bendfeldt K, Stieglitz RD, Drewe J, Radue EW, McGuire PK, Riecher-Rossler A, Borgwardt SJ (2009) The effects of antipsychotics on the brain: what have we learnt from structural imaging of schizophrenia?—a systematic review. Curr Pharm Des 15(22):2535–49PubMedCrossRef
57.
Navari S, Dazzan P (2009) Do antipsychotic drugs affect brain structure? A systematic and critical review of MRI findings. Psychol Med 39(11):1763–77PubMedCrossRef
58.
Ebdrup BH, Skimminge A, Rasmussen H, Aggernaes B, Oranje B, Lublin H, Baare W, Glenthoj B (2011) Progressive striatal and hippocampal volume loss in initially antipsychotic-naïve, first-episode schizophrenia patients treated with quetiapine: relationship to dose and symptoms. Int J Neuropsychopharmacol 14(1):69–82PubMedCrossRef
59.
Lawyer G, Nesvag R, Varnas K, Frigessi A, Agartz I (2008) Investigating possible subtypes of schizophrenic patients and controls based on brain cortical thickness. Psychiatry Res 164(3):254–264PubMedCrossRef
60.
Venkatasubramanian G, Jayakumar PN, Gangadhar BN, Keshavan MS (2008) Automated MRI parcellation study of regional volume and thickness of prefrontal cortex (PFC) in antipsychotic-naïve schizophrenia. Acta Psychiatr Scand 117:420–431PubMedCrossRef
61.
Kyriakopoulos M, Bargiotas T, Barker GJ, Frangou S (2008) Diffusion tensor imaging in schizophrenia. Eur Psychiatry 23(4):255–273PubMedCrossRef
Metadata
Title
Cortical thickness, gray matter volume, and white matter anisotropy and diffusivity in schizophrenia
Authors
Mizuho Murakami
Hidemasa Takao
Osamu Abe
Hidenori Yamasue
Hiroki Sasaki
Wataru Gonoi
Yosuke Takano
Kunio Takei
Kiyoto Kasai
Kuni Ohtomo
Publication date
01-11-2011
Publisher
Springer-Verlag
Published in
Neuroradiology / Issue 11/2011
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-010-0830-2

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