Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Neuroradiology
Published in: Neuroradiology 11/2011

01-11-2011 | Diagnostic Neuroradiology

Usefulness of thallium-201 SPECT in the evaluation of tumor natures in intracranial meningiomas

Authors: Tetsuji Takeda, Takahiro Nakano, Kenichiroh Asano, Norihito Shimamura, Hiroki Ohkuma

Published in: Neuroradiology | Issue 11/2011

Login to get access

Abstract

Introduction

Although intracranial meningiomas are regarded as benign tumors, some of them behave clinically as malignant tumors. Past reports suggest that MIB 1 and vascular endothelial growth factor (VEGF) in postoperative tumor specimens correlate with the aggressive nature of tumors, but preoperative prediction of such a nature is more useful for therapeutic planning for the tumor. The purpose of this study was to assess the usefulness of preoperative thallium-201 chloride single-photon emission computed tomography (Tl SPECT) to evaluate biological behavior in intracranial meningiomas.

Methods

Tl SPECT was performed on 39 patients with intracranial meningioma and Tl uptake indices were calculated. The difference in the Tl uptake index between atypical meningiomas and other pathological types of meningioma was evaluated. Moreover, correlation of Tl uptake indices with the MIB1 labeling index was estimated. Tl uptake indices were also compared between VEGF strongly positive and weakly positive meningiomas.

Results

The delayed index of atypical meningioma was significantly higher than that of the other pathological types (p = 0.036). Significant correlation was found between the Tl uptake index in the delayed image and MIB1 labeling index (p < 0.0001, R 2 = 0.36). Moreover, VEGF strongly positive meningiomas exhibited a significantly higher Tl uptake index compared to VEGF weakly positive meningiomas in both the early image and the delayed image (p = 0.029, 0.023, respectively).

Conclusions

Tl uptake index may be a possible preoperative surrogate marker of MIB1 and VEGF that is useful in detecting aggressive natures in intracranial meningiomas.
Literature
1.
Jaaskelainen J (1986) Seemingly complete removal of histologically benign intracranial meningioma: late recurrence rate and factors predicting recurrence in 657 patients A multivariate analysis. Surg Neurol 26:461–469PubMedCrossRef
2.
Mirimanoff RO, Dosoretz DE, Linggood RM, Ojemann RG, Martuza RL (1985) Meningioma: analysis of recurrence and progression following neurosurgical resection. J Neurosurg 62:18–24PubMedCrossRef
3.
Jaaskelainen J, Haltia M, Servo A (1986) A typical and anaplastic meningiomas: radiology, surgery, radiotherapy, and outcome. Surg Neurol 25:233–242PubMedCrossRef
4.
Adegbite AB, Khan MI, Paine KW, Tan LK (1983) The recurrence of intaracranial meningiomas after surgical treatment. J Neurosurg 58:51–56PubMedCrossRef
5.
Baird M, Gallagher PJ (1989) Reccurent intracranial and spinal meningiomas: clinical and histologidal features. Clin Neuropathol 8:41–44PubMed
6.
Nakasu S, Nakasu Y, Nakajima M, Matsuda M, Handa J (1999) Preoperative identification of meningiomas that are highly likely to reccur. J Neurosurg 90:455–462PubMedCrossRef
7.
Ho DM, Hsu CY, Ting LT, Chiang H (2002) Histopathology and MIB-1 labbeling index predicted recurrence of meningiomas: a proposal of diagnostic criteria for patients with atypical meningioma. Cancer 94:1538–1547PubMedCrossRef
8.
Simpson D (1957) The recurrence of intracranial meningiomas after surgical treatment. J Neurol Neurosurg Psychiatry 20:22–39PubMedCrossRef
9.
Black KL, Hawkins RA, Kim KT, Becker DP, Lerner C, Marciano D (1989) Use of thallium-201 SPECT to quantitate malignancy grade of gliomas. J Neurosurg 71:342–346PubMedCrossRef
10.
Igase K, Oka Y, Ohta S, Murakami Y, Kumon Y, Sasaki S (1996) Usefulness of thallium-201 single photon emission computed tomography to quantify the malignancy grade of brain tumors. Neurol Med Chir (Tokyo) 36:434–439CrossRef
11.
Ishibashi M, Taguchi A, Sugita Y et al (1995) Thallium-201 in brain tumors: relationship between tumor cell activity in astrocytic tumor and proliferating cell nuclear antigen. J Nucl Med 36:2201–2207PubMed
12.
Kahn D, Follett KA, Bushnell DL et al (1994) Diagnosis of recurrent brain tumor: value of 201Tl SPECT vs 18 F-fluorodeoxyglucose PET. AJR 163:1459–1466PubMed
13.
Kosuda S, Fujii H, Aoki S et al (1993) Reassessment of quantitative thallium-201 brain SPECT for miscellaneous brain tumors. Ann Nucl Med 7:257–263PubMedCrossRef
14.
Lorberboym M, Baram J, Feibel M, Hercbergs A, Lieberman L (1995) A Prospective evaluation of thallium-201 single photon emission computerized tomography for brain tumor burden. Int J Radiat Oncol Biol Phys 32:249–254PubMed
15.
Rubinstein R, Karger H, Pietrzyk U, Siegal T, Gomori JM, Chisin R (1996) Use of 201Thallium brain SPECT, image registration, and semi-quantitative analysis in the follow-up of brain tumors. Eur J Radiol 21:188–195PubMedCrossRef
16.
Jinnouchi S, Hoshi H, Ohnishi T, Futami S, Nagamachi S, Watanabe K et al (1993) Thallium-201 SPECT for predicting histological types of meningiomas. J Nucl Med 34(12):2091–2094PubMed
17.
Kinuya K, Ohashi M, Itoh S, Sakai S, Yamamoto K, Kakuda K et al (2003) Thallium-201 brain SPECT to diagnose aggressiveness of meningiomas. Ann Nucl Med 17(6):463–467PubMedCrossRef
18.
Tedeschi E, Soricelli A, Brunetti A, Romano M, Bucciero A, Iaconetta G et al (1996) Different thallium-201 single-photon emission tomographic patterns in benign and aggressive meningiomas. Eur J Nucl Med 23:1478–1484PubMedCrossRef
19.
Cattoretti G, Becker MHG, Key G et al (1992) Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB1 and MIB3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 168:357–363PubMedCrossRef
20.
Maiuri F, De Caro MB, Esposito F, Cappabianca P, Strazzullo V, Pettinato G, Divitiis E (2007) Recurrences of meningiomas: predictive value of pathological features and hormonal and growth factors. J Neuro-Oncol 82:63–68CrossRef
21.
Goldman CK, Bharara S, Palmer CA, Vitek J, Tsai JC, Weiss HL, Gillespie GY (1997) Brain edema in meningiomas is associated with increased vascular endothelial growth factor expression. Neurosurgery 40:1269–1277PubMedCrossRef
22.
Provias J, Claffey K, delAguila L, Lau N, Feldkamp M, Guha A (1997) Meningiomas: role of vascular endothelial growth factor/vascular permeability factor in angiogenesis and peritumoral edema. Neurosurgery 40:1016–1026PubMedCrossRef
23.
Kalkanis SN, Carroll RS, Zhang J, Zamani AA, Black PM (1996) Correlation of vascular endothelial growth factor messenger RNA expression with peritumoral vasogenic cerebral edema in meningiomas. J Neurosurg 85:1095–1101PubMedCrossRef
24.
Lamszus K, Lengler U, Schmidt NO, Stavrou D, Ergün S, Westphal M (2000) Vascular endothelial growth factor, hepatocyte growth factor/scatter factor, basic fibroblast growth factor, and placenta growth factor in human meningiomas and their relation to angiogenesis and malignancy. Neurosurgery 46(4):938–947, discussion 947-948PubMed
25.
Yamasaki F, Yoshioka H, Hama S, Sugiyama K, Arita K, Kurisu K (2000) Recurrence of meningiomas. Cancer 89:1102–1110PubMedCrossRef
26.
Nakano T, Asano K, Tanaka M, Takahashi T, Miura H, Suzuki S (2001) Use of 201 Tl SPECT for evaluation of biologic behavior in pituitary adenomas. J Nucl Med 42(4):575–578PubMed
Metadata
Title
Usefulness of thallium-201 SPECT in the evaluation of tumor natures in intracranial meningiomas
Authors
Tetsuji Takeda
Takahiro Nakano
Kenichiroh Asano
Norihito Shimamura
Hiroki Ohkuma
Publication date
01-11-2011
Publisher
Springer-Verlag
Published in
Neuroradiology / Issue 11/2011
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-010-0822-2

Other articles of this Issue 11/2011

Neuroradiology 11/2011 Go to the issue

Continuing Education

Autoimmune-mediated encephalitis

Paediatric Neuroradiology

Image evaluation of HIV encephalopathy: a multimodal approach using quantitative MR techniques

Functional Neuroradiology

Fractional anisotropy and mean diffusivity in the corpus callosum of patients with multiple sclerosis: the effect of physiotherapy

Diagnostic Neuroradiology

Cortical thickness, gray matter volume, and white matter anisotropy and diffusivity in schizophrenia

Interventional Neuroradiology

Analysis of aneurysm rupture in relation to the geometric indices: aspect ratio, volume, and volume-to-neck ratio

Head and Neck Radiology

Lymphomas and metastases of the extra-ocular musculature