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Neuroradiology
Published in: Neuroradiology 12/2010

01-12-2010 | Diagnostic Neuroradiology

Utility of susceptibility-weighted MRI in differentiating Parkinson’s disease and atypical parkinsonism

Authors: Deepak Gupta, Jitender Saini, Chandrasekharan Kesavadas, P. Sankara Sarma, Asha Kishore

Published in: Neuroradiology | Issue 12/2010

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Abstract

Introduction

Neuropathological studies report varying patterns of brain mineralization in Parkinson’s diseases (PD), progressive supranuclear palsy (PSP), and Parkinson variant of multiple system atrophy (MSA-P). Susceptibility-weighted imaging (SWI) is the ideal magnetic resonance imaging (MRI) technique to detect mineralization of the brain. The purpose of this study was to test if SWI can differentiate PD, PSP, and MSA-P.

Methods

Eleven patients with PD, 12 with PSP, 12 with MSA-P, and 11 healthy controls underwent SWI of the brain. Hypointensity of putamen, red nucleus, substantia nigra, and dentate nucleus in all groups were measured using an objective grading scale and scored from 0 to 3.

Results

In PSP, hypointensity score of red nucleus was higher than that in MSA-P (p = 0.001) and PD (p = 0.001), and a score of ≥2 differentiated the PSP group from the PD and MSA-P groups. Putaminal hypointensity score was higher in PSP when compared to that in PD (p = 0.003), and a score of ≥2 differentiated PSP from PD groups. SWI hypointensity scores of red nucleus and putamen had an excellent intrarater and interrater correlation. Substantia nigra hypointensity score of the PSP group was higher than that of the MSA-P (p = 0.004) and PD (p = 0.006) groups, but the scores had only a moderate intrarater and interrater correlation.

Conclusions

SWI shows different patterns of brain mineralization in clinically diagnosed groups of PD, PSP, and MSA-P and may be considered as an additional MR protocol to help differentiate these conditions.
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Metadata
Title
Utility of susceptibility-weighted MRI in differentiating Parkinson’s disease and atypical parkinsonism
Authors
Deepak Gupta
Jitender Saini
Chandrasekharan Kesavadas
P. Sankara Sarma
Asha Kishore
Publication date
01-12-2010
Publisher
Springer-Verlag
Published in
Neuroradiology / Issue 12/2010
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI
https://doi.org/10.1007/s00234-010-0677-6

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