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Published in: Calcified Tissue International 6/2021

01-12-2021 | Affective Disorder | Original Research

Depression and Osteoporosis: A Mendelian Randomization Study

Authors: Bin He, Qiong Lyu, Lifeng Yin, Muzi Zhang, Zhengxue Quan, Yunsheng Ou

Published in: Calcified Tissue International | Issue 6/2021

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Abstract

Observational studies suggest a link between depression and osteoporosis, but these may be subject to confounding and reverse causality. In this two-sample Mendelian randomization analysis, we included the large meta-analysis of genome-wide association studies for depression among 807,553 individuals (246,363 cases and 561,190 controls) of European descent, the large meta-analysis to identify genetic variants associated with femoral neck bone mineral density (FN-BMD), forearm BMD (FA-BMD) and lumbar spine BMD (LS-BMD) among 53,236 individuals of European ancestry, and the GWAS summary data of heel BMD (HE-BMD) and fracture among 426,824 individuals of European ancestry. The results revealed that genetic predisposition towards depression showed no causal effect on FA-BMD (beta-estimate: 0.091, 95% confidence interval [CI] − 0.088 to 0.269, SE:0.091, P value = 0.320), FN-BMD (beta-estimate: 0.066, 95% CI − 0.016 to 0.148, SE:0.042, P value = 0.113), LS-BMD (beta-estimate: 0.074, 95% CI − 0.029 to 0.177, SE:0.052, P value = 0.159), HE-BMD (beta-estimate: 0.009, 95% CI − 0.043 to 0.061, SE:0.027, P value = 0.727), or fracture (beta-estimate: 0.008, 95% CI − 0.071 to 0.087, SE:0.041, P value = 0.844). These results were also confirmed by multiple sensitivity analyses. Contrary to the findings of observational studies, our results do not reveal a causal role of depression in osteoporosis or fracture.
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Metadata
Title
Depression and Osteoporosis: A Mendelian Randomization Study
Authors
Bin He
Qiong Lyu
Lifeng Yin
Muzi Zhang
Zhengxue Quan
Yunsheng Ou
Publication date
01-12-2021
Publisher
Springer US
Published in
Calcified Tissue International / Issue 6/2021
Print ISSN: 0171-967X
Electronic ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-021-00886-5

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