Published in:
01-05-2018 | Editorial
Osteoimmunology
Authors:
Stuart H. Ralston, Georg Schett
Published in:
Calcified Tissue International
|
Issue 5/2018
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Excerpt
Interactions between the immune system and bone were initially recognised more than 35 years ago with the discovery by Horton that activated peripheral blood leukocytes release a soluble activity that stimulates osteoclastic bone resorption [
1]. With advances in cell and molecular biology, several molecules have since been discovered that play roles both in the regulation of bone remodelling and immune responses, most notably receptor activator of nuclear factor kappa B (RANK) and RANK Ligand (RANKL) which were initially identified as mediators of T-cell activation and dendritic cell function [
2] but which then were found to be crucial regulators of osteoclastogenesis [
3]. …
