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Published in: Calcified Tissue International 3/2014

01-09-2014 | Original Research

The Correlation Between Lateral Bowing Angle of the Femur and the Location of Atypical Femur Fractures

Authors: Lei-Po Chen, Ting-Kuo Chang, Te-Yang Huang, Tiew-Guan Kwok, Yung-Chang Lu

Published in: Calcified Tissue International | Issue 3/2014

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Abstract

This study is the first to report the use of data on incomplete atypical femur fracture (AFF) to evaluate the curvature of femur and explore the relationship between lateral femoral bowing angle (FBA) and AAF location. In this study, we obtained 17 cases of incomplete AFF and calculated the accurate lateral FBA and location ratio of the incomplete fracture. Incomplete fracture location was defined as a percentage (length from lesion to greater trochanter tip/entire femur length %; greater trochanter tip: 0 %; femoral condyles: 100 %). A lateral FBA of 7° was set as the point of demarcation. Eleven femurs had a lateral FBA ≤ 7° (group 1), with a median lateral FBA of 4.75° (IQR 2.5–5.9°) and a median of incomplete AFF location at 25.2 % (IQR 23.4–30.1 %). Another six femurs had a FBA > 7° (group 2) with a median of 1.8° (IQR 10.2–14.3°) and a median location at 47.7 % (IQR 38.6–54.5 %). There was a significant statistical difference in location (p < 0.05) between the two groups. The rate of BP use was 87.5 % in group 1 which was higher than 60 % in group 2. There was some degree of positive correlation between the bowing angle and location in simple linear regression (r 2 = 0.549, p < 0.001, ß = 1.789). AAFs located in diaphysis were associated with large lateral FBA. On the other hand, AAFs located in subtrochanteric region were more commonly found in femurs with smaller lateral FBA. In conclusion, the degree of the FBA was associated with AFF location.
Literature
1.
go back to reference Black DM et al (1996) Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet 348(9041):1535–1541PubMedCrossRef Black DM et al (1996) Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet 348(9041):1535–1541PubMedCrossRef
2.
go back to reference Harris ST et al (1999) Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. JAMA 282(14):1344–1352PubMedCrossRef Harris ST et al (1999) Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. JAMA 282(14):1344–1352PubMedCrossRef
3.
go back to reference Black DM et al (2007) Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 356(18):1809–1822PubMedCrossRef Black DM et al (2007) Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 356(18):1809–1822PubMedCrossRef
4.
go back to reference Body JJ (2006) Bisphosphonates for malignancy-related bone disease: current status, future developments. Support Care Cancer 14(5):408–418PubMedCrossRef Body JJ (2006) Bisphosphonates for malignancy-related bone disease: current status, future developments. Support Care Cancer 14(5):408–418PubMedCrossRef
5.
go back to reference Black DM et al (2010) Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur. N Engl J Med 362(19):1761–1771PubMedCrossRef Black DM et al (2010) Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur. N Engl J Med 362(19):1761–1771PubMedCrossRef
6.
go back to reference Lenart BA, Lorich DG, Lane JM (2008) Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate. N Engl J Med 358(12):1304–1306PubMedCrossRef Lenart BA, Lorich DG, Lane JM (2008) Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate. N Engl J Med 358(12):1304–1306PubMedCrossRef
7.
go back to reference Schilcher J, Michaelsson K, Aspenberg P (2011) Bisphosphonate use and atypical fractures of the femoral shaft. N Engl J Med 364(18):1728–1737PubMedCrossRef Schilcher J, Michaelsson K, Aspenberg P (2011) Bisphosphonate use and atypical fractures of the femoral shaft. N Engl J Med 364(18):1728–1737PubMedCrossRef
8.
go back to reference Dell RM et al (2012) Incidence of atypical nontraumatic diaphyseal fractures of the femur. J Bone Miner Res 27(12):2544–2550PubMedCrossRef Dell RM et al (2012) Incidence of atypical nontraumatic diaphyseal fractures of the femur. J Bone Miner Res 27(12):2544–2550PubMedCrossRef
9.
go back to reference Meier RP et al (2012) Increasing occurrence of atypical femoral fractures associated with bisphosphonate use. Arch Intern Med 172(12):930–936PubMedCrossRef Meier RP et al (2012) Increasing occurrence of atypical femoral fractures associated with bisphosphonate use. Arch Intern Med 172(12):930–936PubMedCrossRef
10.
go back to reference Shane E et al (2013) Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 29(1):1–23PubMedCrossRef Shane E et al (2013) Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 29(1):1–23PubMedCrossRef
11.
go back to reference Capeci CM, Tejwani NC (2009) Bilateral low-energy simultaneous or sequential femoral fractures in patients on long-term alendronate therapy. J Bone Joint Surg Am 91(11):2556–2561PubMedCrossRef Capeci CM, Tejwani NC (2009) Bilateral low-energy simultaneous or sequential femoral fractures in patients on long-term alendronate therapy. J Bone Joint Surg Am 91(11):2556–2561PubMedCrossRef
13.
go back to reference Lee JK (2009) Bilateral atypical femoral diaphyseal fractures in a patient treated with alendronate sodium. Int J Rheum Dis 12(2):149–154PubMedCrossRef Lee JK (2009) Bilateral atypical femoral diaphyseal fractures in a patient treated with alendronate sodium. Int J Rheum Dis 12(2):149–154PubMedCrossRef
14.
go back to reference Giusti A, Hamdy NA, Papapoulos SE (2010) Atypical fractures of the femur and bisphosphonate therapy: a systematic review of case/case series studies. Bone 47(2):169–180PubMedCrossRef Giusti A, Hamdy NA, Papapoulos SE (2010) Atypical fractures of the femur and bisphosphonate therapy: a systematic review of case/case series studies. Bone 47(2):169–180PubMedCrossRef
15.
16.
go back to reference Sasaki S et al (2012) Low-energy diaphyseal femoral fractures associated with bisphosphonate use and severe curved femur: a case series. J Bone Miner Metab 30(5):561–567PubMedCrossRef Sasaki S et al (2012) Low-energy diaphyseal femoral fractures associated with bisphosphonate use and severe curved femur: a case series. J Bone Miner Metab 30(5):561–567PubMedCrossRef
17.
go back to reference Hsu RW et al (1990) Normal axial alignment of the lower extremity and load-bearing distribution at the knee. Clin Orthop Relat Res 255:215–227PubMed Hsu RW et al (1990) Normal axial alignment of the lower extremity and load-bearing distribution at the knee. Clin Orthop Relat Res 255:215–227PubMed
18.
go back to reference Yau WP et al (2007) Coronal bowing of the femur and tibia in Chinese: its incidence and effects on total knee arthroplasty planning. J Orthop Surg (Hong Kong) 15(1):32–36 Yau WP et al (2007) Coronal bowing of the femur and tibia in Chinese: its incidence and effects on total knee arthroplasty planning. J Orthop Surg (Hong Kong) 15(1):32–36
19.
go back to reference Koh JS et al (2011) Distribution of atypical fractures and cortical stress lesions in the femur: implications on pathophysiology. Singapore Med J 52(2):77–80PubMed Koh JS et al (2011) Distribution of atypical fractures and cortical stress lesions in the femur: implications on pathophysiology. Singapore Med J 52(2):77–80PubMed
20.
go back to reference Shane E et al (2010) Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 25(11):2267–2294PubMedCrossRef Shane E et al (2010) Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 25(11):2267–2294PubMedCrossRef
21.
go back to reference Allen MR, Burr DB (2007) Three years of alendronate treatment results in similar levels of vertebral microdamage as after one year of treatment. J Bone Miner Res 22(11):1759–1765PubMedCrossRef Allen MR, Burr DB (2007) Three years of alendronate treatment results in similar levels of vertebral microdamage as after one year of treatment. J Bone Miner Res 22(11):1759–1765PubMedCrossRef
22.
go back to reference Brennan O et al (2011) Effects of estrogen deficiency and bisphosphonate therapy on osteocyte viability and microdamage accumulation in an ovine model of osteoporosis. J Orthop Res 29(3):419–424PubMedCrossRef Brennan O et al (2011) Effects of estrogen deficiency and bisphosphonate therapy on osteocyte viability and microdamage accumulation in an ovine model of osteoporosis. J Orthop Res 29(3):419–424PubMedCrossRef
23.
go back to reference Renders GA et al (2011) Mineral heterogeneity affects predictions of intratrabecular stress and strain. J Biomech 44(3):402–407PubMedCrossRef Renders GA et al (2011) Mineral heterogeneity affects predictions of intratrabecular stress and strain. J Biomech 44(3):402–407PubMedCrossRef
24.
go back to reference Saito M et al (2008) Collagen maturity, glycation induced-pentosidine, and mineralization are increased following 3-year treatment with incadronate in dogs. Osteoporos Int 19(9):1343–1354PubMedCrossRef Saito M et al (2008) Collagen maturity, glycation induced-pentosidine, and mineralization are increased following 3-year treatment with incadronate in dogs. Osteoporos Int 19(9):1343–1354PubMedCrossRef
25.
go back to reference Tang SY et al (2009) Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate. Osteoporos Int 20(6):887–894PubMedCentralPubMedCrossRef Tang SY et al (2009) Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate. Osteoporos Int 20(6):887–894PubMedCentralPubMedCrossRef
26.
go back to reference Unnanuntana A et al (2013) Atypical femoral fractures: what do we know about them?: AAOS exhibit selection. J Bone Joint Surg Am 95(2):e8–e13PubMedCrossRef Unnanuntana A et al (2013) Atypical femoral fractures: what do we know about them?: AAOS exhibit selection. J Bone Joint Surg Am 95(2):e8–e13PubMedCrossRef
27.
go back to reference Mullaji AB, Marawar SV, Mittal V (2009) A comparison of coronal plane axial femoral relationships in Asian patients with varus osteoarthritic knees and healthy knees. J Arthroplast 24(6):861–867CrossRef Mullaji AB, Marawar SV, Mittal V (2009) A comparison of coronal plane axial femoral relationships in Asian patients with varus osteoarthritic knees and healthy knees. J Arthroplast 24(6):861–867CrossRef
28.
go back to reference Nagamine R et al (2000) Anatomic variations should be considered in total knee arthroplasty. J Orthop Sci 5(3):232–237PubMedCrossRef Nagamine R et al (2000) Anatomic variations should be considered in total knee arthroplasty. J Orthop Sci 5(3):232–237PubMedCrossRef
29.
go back to reference Crossley K et al (1999) Ground reaction forces, bone characteristics, and tibial stress fracture in male runners. Med Sci Sports Exerc 31(8):1088–1093PubMedCrossRef Crossley K et al (1999) Ground reaction forces, bone characteristics, and tibial stress fracture in male runners. Med Sci Sports Exerc 31(8):1088–1093PubMedCrossRef
30.
go back to reference Roschger P et al (2001) Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone 29(2):185–191PubMedCrossRef Roschger P et al (2001) Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone 29(2):185–191PubMedCrossRef
31.
go back to reference Boskey AL, Spevak L, Weinstein RS (2009) Spectroscopic markers of bone quality in alendronate-treated postmenopausal women. Osteoporos Int 20(5):793–800PubMedCentralPubMedCrossRef Boskey AL, Spevak L, Weinstein RS (2009) Spectroscopic markers of bone quality in alendronate-treated postmenopausal women. Osteoporos Int 20(5):793–800PubMedCentralPubMedCrossRef
32.
go back to reference Donnelly E et al (2012) Reduced cortical bone compositional heterogeneity with bisphosphonate treatment in postmenopausal women with intertrochanteric and subtrochanteric fractures. J Bone Miner Res 27(3):672–678PubMedCrossRef Donnelly E et al (2012) Reduced cortical bone compositional heterogeneity with bisphosphonate treatment in postmenopausal women with intertrochanteric and subtrochanteric fractures. J Bone Miner Res 27(3):672–678PubMedCrossRef
33.
go back to reference Roschger P et al (2008) Bone mineralization density distribution in health and disease. Bone 42(3):456–466PubMedCrossRef Roschger P et al (2008) Bone mineralization density distribution in health and disease. Bone 42(3):456–466PubMedCrossRef
34.
go back to reference Huang TW et al (2011) Total knee replacement in patients with significant femoral bowing in the coronal plane: a comparison of conventional and computer-assisted surgery in an Asian population. J Bone Joint Surg Br 93(3):345–350PubMedCrossRef Huang TW et al (2011) Total knee replacement in patients with significant femoral bowing in the coronal plane: a comparison of conventional and computer-assisted surgery in an Asian population. J Bone Joint Surg Br 93(3):345–350PubMedCrossRef
35.
go back to reference Maratt J et al (2014) Variation in the femoral bow: a novel high-throughput analysis of 3922 femurs on cross-sectional imaging. J Orthop Trauma 28(1):6–9PubMedCrossRef Maratt J et al (2014) Variation in the femoral bow: a novel high-throughput analysis of 3922 femurs on cross-sectional imaging. J Orthop Trauma 28(1):6–9PubMedCrossRef
36.
go back to reference Mohan PC et al (2013) Radiographic features of multifocal endosteal thickening of the femur in patients on long-term bisphosphonate therapy. Eur Radiol 23(1):222–227PubMedCrossRef Mohan PC et al (2013) Radiographic features of multifocal endosteal thickening of the femur in patients on long-term bisphosphonate therapy. Eur Radiol 23(1):222–227PubMedCrossRef
Metadata
Title
The Correlation Between Lateral Bowing Angle of the Femur and the Location of Atypical Femur Fractures
Authors
Lei-Po Chen
Ting-Kuo Chang
Te-Yang Huang
Tiew-Guan Kwok
Yung-Chang Lu
Publication date
01-09-2014
Publisher
Springer US
Published in
Calcified Tissue International / Issue 3/2014
Print ISSN: 0171-967X
Electronic ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-014-9887-y

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