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Osteoporosis International
Published in: Osteoporosis International 8/2019

01-08-2019 | Biomarkers | Original Article

Dietary inflammatory index® and cortical bone outcomes in healthy adolescent children

Authors: L. M. Coheley, N. Shivappa, J. R. Hebert, R. D. Lewis

Published in: Osteoporosis International | Issue 8/2019

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Abstract

Summary

Diet is thought to modulate inflammation. This study shows no relationships between the dietary inflammatory index (DII) and biomarkers of inflammation or bone after adjusting for covariates. Monocyte chemoattractant protein-1 was inversely associated with peripheral tibia cortical thickness and prospective childhood studies should be conducted to better understand this relationship and to determine if there are long-term consequences in adulthood.

Introduction

Examine the relationships between the DII-scores and bone and biomarkers of inflammation in 290 adolescents, ages 9–13 years.

Methods

DII-scores were calculated from 3-day diet records and categorized into tertiles, low (< − 1.34), medium (− 1.34 to 1.41), and high (> 1.41) inflammation. Radius and tibia bone were assessed via peripheral quantitative computed tomography (Stratec XCT 2000) at the 66% site relative to the distal growth plate. Fasting serum was measured for tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1). The relationships between DII-scores and bone and biomarkers of inflammation were assessed using bivariate and partial correlations adjusting for sexual maturation, sex, race, muscle cross-sectional area, and height. ANOVA/ANCOVA models were used to compare DII-tertiles with dependent variables.

Results

DII-scores were negatively associated with tibia trabecular area (TtAr; r = − .141, P = .019), periosteal perimeter (PsPM; r = − .145, P = .016), endosteal perimeter (r = − .145, P = .016), strength strain index (SSI; r = − .129, P = .032), and radius TtAr (r = − .140, P = .020), PsPM (r = −.138, P = .027) and SSI (r = −.131, P = .036) but nullified when adjusting for covariates. Tibia PsPM was higher in the low DII group compared to the medium (P = .050) and high (P = .046) groups but nullified after controlling for covariates. DII-scores were not associated with TNF-α, VEGF, or IL-6, but were associated with MCP-1 only in the unadjusted model (r = .125, P = .042). In the adjusted model, MCP-1 was inversely associated with tibia cortical thickness (r = −.150 P = .030).

Conclusion

The DII-scores were not related to biomarkers of inflammation or bone; however, the biomarker of inflammation, MCP-1 was negatively associated with tibia CtTh. Future prospective pediatric studies should be conducted to better understand this relationship and determine if there are long-term implications in adulthood.
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Metadata
Title
Dietary inflammatory index® and cortical bone outcomes in healthy adolescent children
Authors
L. M. Coheley
N. Shivappa
J. R. Hebert
R. D. Lewis
Publication date
01-08-2019
Publisher
Springer London
Keyword
Biomarkers
Published in
Osteoporosis International / Issue 8/2019
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-019-04946-3

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