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Osteoporosis International
Published in: Osteoporosis International 8/2018

01-08-2018 | Review

Assessment of bone quality in patients with diabetes mellitus

Authors: N. Jiang, W. Xia

Published in: Osteoporosis International | Issue 8/2018

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Abstract

Substantial evidence exists that diabetes mellitus is associated with an increased risk of osteoporotic fractures. Low bone strength as well as bone extrinsic factors are probably contributing to the increased bone fragility in diabetes. Bone density and quality are important determinants of bone strength. Although bone mineral density (BMD) and the fracture risk assessment tool (FRAX) are very useful clinical tools in assessing bone strength, they may underestimate the fracture risk in diabetes mellitus. Through advances in new technologies such as trabecular bone score (TBS) and peripheral quantitative computed tomography (pQCT), we can better assess the bone quality and fracture risk of patients with diabetes mellitus. Invasive assessments such as microindentation and histomorphometry have been great complement to the existing bone analysis techniques. Bone turnover markers have been found to be altered in diabetes mellitus patients and may be associated with fractures. This review will give a brief summary of the current development and clinical uses of these assessments.
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Metadata
Title
Assessment of bone quality in patients with diabetes mellitus
Authors
N. Jiang
W. Xia
Publication date
01-08-2018
Publisher
Springer London
Published in
Osteoporosis International / Issue 8/2018
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-018-4532-7

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