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Osteoporosis International

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01-08-2017 | Original Article

Meta-analysis of hypertension and osteoporotic fracture risk in women and men

Authors: C. Li, Y. Zeng, L. Tao, S. Liu, Z. Ni, Q. Huang, Q. Wang

Published in: Osteoporosis International | Issue 8/2017

Abstract

Summary

The present meta-analysis synthesized evidence from 10 articles encompassing 28 independent studies to verify the association between hypertension and osteoporotic fracture risk in women and men. Our results indicate that the risk of osteoporotic fracture among individuals with hypertension was higher than that among individuals without hypertension.

Introduction

Epidemiological studies have suggested that hypertension is related to osteoporotic fracture. However, discrepancies exist in the reported findings. In this study, a systematic review of relevant published articles was conducted to verify the association between hypertension and osteoporotic fracture risk in women and men.

Methods

PubMed (1953_October 5th, 2016) and Embase (1974_October 5th, 2016) were systematically searched for relevant articles. Odds ratios (ORs) and confidence intervals (CIs) were derived using random effect models. Categorical, subgroup, heterogeneity, publication bias, and meta-regression analyses were conducted.

Results

We analyzed 10 articles encompassing 28 independent studies, 1,430,431 participants, and 148,048 osteoporotic fracture cases. The risk of osteoporotic fracture among individuals with hypertension was higher (pooled OR = 1.33, 95% CI 1.25–1.40; I ² = 72.3%, P < 0.001) than that among individuals without hypertension. The association between hypertension and fracture risk was slightly stronger in women (pooled OR = 1.52, 95% CI 1.30–1.79) than in men (pooled OR = 1.35, 95% CI 1.26–1.44). Studies conducted in Asia revealed results that were consistent with those of studies performed in Europe.

Conclusions

Hypertension is associated with osteoporotic fracture risk. However, the biological mechanisms underlying the effect of hypertension on osteoporotic fracture remain to be elucidated.

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Title: Meta-analysis of hypertension and osteoporotic fracture risk in women and men
Authors: C. Li
Y. Zeng
L. Tao
S. Liu
Z. Ni
Q. Huang
Q. Wang
Publication date: 01-08-2017
Publisher: Springer London
Published in: Osteoporosis International / Issue 8/2017
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-017-4050-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Meta-analysis of hypertension and osteoporotic fracture risk in women and men

Abstract

Summary

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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