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Osteoporosis International
Published in: Osteoporosis International 8/2017

01-08-2017 | Original Article

Greater yogurt consumption is associated with increased bone mineral density and physical function in older adults

Authors: E. Laird, A. M. Molloy, H. McNulty, M. Ward, K. McCarroll, L. Hoey, C. F. Hughes, C. Cunningham, J. J. Strain, M. C. Casey

Published in: Osteoporosis International | Issue 8/2017

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Abstract

Summary

In this cohort of community dwelling older adults (>60 years), we observed significant positive associations between the frequencies of yogurt intake with measures of bone density, bone biomarkers, and indicators of physical function. Improving yogurt intakes could be a valuable health strategy for maintaining bone health in older adults.

Introduction

The associations of yogurt intakes with bone health and frailty in older adults are not well documented. The aim was to investigate the association of yogurt intakes with bone mineral density (BMD), bone biomarkers, and physical function in 4310 Irish adults from the Trinity, Ulster, Department of Agriculture aging cohort study (TUDA).

Methods

Bone measures included total hip, femoral neck, and vertebral BMD with bone biochemical markers. Physical function measures included Timed Up and Go (TUG), Instrumental Activities of Daily Living Scale, and Physical Self-Maintenance Scale.

Results

Total hip and femoral neck BMD in females were 3.1–3.9% higher among those with the highest yogurt intakes (n = 970) compared to the lowest (n = 1109; P < 0.05) as were the TUG scores (−6.7%; P = 0.013). In males, tartrate-resistant acid phosphatase (TRAP 5b) concentrations were significantly lower in those with the highest yogurt intakes (−9.5%; P < 0.0001). In females, yogurt intake was a significant positive predictor of BMD at all regions. Each unit increase in yogurt intake in females was associated with a 31% lower risk of osteopenia (OR 0.69; 95% CI 0.49–0.96; P = 0.032) and a 39% lower risk of osteoporosis (OR 0.61; 95% CI 0.42–0.89; P = 0.012) and in males, a 52% lower risk of osteoporosis (OR 0.48; 95% CI 0.24–0.96; P = 0.038).

Conclusion

In this cohort, higher yogurt intake was associated with increased BMD and physical function scores. These results suggest that improving yogurt intakes could be a valuable public health strategy for maintaining bone health in older adults.
Appendix
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Literature
1.
2.
Ström O, Borgström F, Kanis AJ, Compston J, Cooper C, McCloskey EV, Jönsson B (2011) Osteoporosis: burden, healthcare provision and opportunities in the EU. Arch Osteoporos 6(1):59–155PubMedCrossRef
3.
Curtis JR, Blume SW (2011) Medical costs of osteoporosis in the elderly Medicare population. Osteoporos Int 22(6):1835–1844PubMedCrossRef
4.
Holroyd C, Cooper C, Dennison E (2008) Epidemiology of osteoporosis. Best Pract Res Clin Endoc Meta 22(5):671–685CrossRef
5.
Hernlund E, Svedbom A, Ivergård M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jönsson B, Kanis JA (2013) Osteoporosis in the European Union: medical management, epidemiology and economic burden. Arch Osteoporos 8(1–2):1–15
6.
Becker DJ, Kilgore ML, Morrisey MA (2010) The societal burden of osteoporosis. Curr Rheumatol Rep 2(3):186–191CrossRef
7.
8.
Greco EA, Fornari R, Rossi F et al (2010) Is obesity protective for osteoporosis? Evaluation of bone mineral density in individuals with high body mass index. Int J Clin Pract 64(6):817–820PubMedCrossRef
9.
Rizzoli R (2008) Nutrition: its role in bone health. Best Pract Res Clin Endocrinol Metab 22(5):813–829PubMedCrossRef
10.
Prentice AM (2014) Dairy products in global public health. Am J Clin Nutr 99(5):1212–1216CrossRef
11.
Rice BH, Quann EE, Miller GD (2013) Meeting and exceeding dairy recommendations: effects of dairy consumption on nutrient intakes and risk of chronic disease. Nutr Rev 71(4):209–223PubMedPubMedCentralCrossRef
12.
13.
Clarke M, Ward M, Strain JJ, Hoey L, Dickey W, McNulty H (2014) B-vitamins and bone in health and disease: the current evidence. Proc Nutr Soc 73(2):330–339PubMedCrossRef
14.
Rizzoli R, Abraham C, Brandi ML (2014) Nutrition and bone health: turning knowledge and beliefs into healthy behaviour. Curr Med Res Opin 30(1):131–141PubMedCrossRef
15.
16.
Dietary guidelines for Americans (2005) Dietary guidelines advisory committee report. 6. U.S. Department of Health and Human Services and U.S. Department of Agriculture, U.S. Government; Washington
17.
Sahni S, Tucker KL, Kiel DP, Quach L, Casey VA, Hannan MT (2013) Milk and yogurt consumption are linked with higher bone mineral density but not with hip fracture: the Framingham Offspring Study. Arch Osteoporos 8(1–2):1–9
18.
Laird E, McNulty H, Ward M et al (2014) Vitamin D deficiency is associated with inflammation in older Irish adults. J Clin Endocrinol Metab 99(5):1807–1815PubMedCrossRef
19.
McCarroll K, Beirne A, Casey M et al (2015) Determinants of 25-hydroxyvitamin D in older Irish adults. Age Ageing 44(5):847–853PubMedCrossRef
20.
Molloy AM, Pangilinan F, Mills JL et al (2016) A common polymorphism in HIBCH influences methylmalonic acid concentrations in blood independently of cobalamin. Am J Hum Genet 98(5):869–882PubMedPubMedCentralCrossRef
21.
Laird E, Casey MC, Ward M et al (2016) Dairy intakes in older Irish adults and effects on vitamin micronutrient status: Data from the TUDA study. J Nutr Health Aging. In Press
22.
Irish Universities Nutrition Alliance (2013) The Irish food portion sizes database (1st edition) 2013
23.
World Health Organization (1992) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: report of a WHO study group (meeting held in Rome from 22 to 25 June 1992)
24.
Bischoff HA, Stähelin HB, Monsch AU et al (2003) Identifying a cut-off point for normal mobility: a comparison of the timed ‘up and go’ test in community-dwelling and institutionalised elderly women. Age Ageing 32(3):315–320PubMedCrossRef
25.
Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9(3):179–186PubMedCrossRef
26.
Hochberg MC, Greenspan S, Wasnich RD, Miller P, Thompson DE, Ross PD (2002) Changes in bone density and turnover explain the reductions in incidence of non-vertebral fractures that occur during treatment with anti-resorptive agents. J Clin Endocrinol Metab 87(4):1586–1592PubMedCrossRef
27.
Henriksen K, Tanko LB, Qvist P, Delmas PD, Christiansen C, Karsdal MA (2007) Assessment of osteoclast number and function: application in the development of new and improved treatment modalities for bone diseases. Osteoporos Int 18(5):681–685PubMedCrossRef
28.
Bonjour JP, Benoit V, Payen F, Kraenzlin M (2013) Consumption of yogurts fortified in vitamin D and calcium reduces serum parathyroid hormone and markers of bone resorption: a double-blind randomized controlled trial in institutionalized elderly women. J Clin Endocrinol Metab 98(7):2915–2921PubMedCrossRef
29.
Schoene D, Wu SM, Mikolaizak AS, Menant JC, Smith ST, Delbaere K, Lord SR (2013) Discriminative ability and predictive validity of the timed up and go test in identifying older people who fall: systematic review and meta-analysis. J Am Geriatr Soc 61(2):202–208PubMedCrossRef
30.
Lana A, Rodriguez-Artalejo F, Lopez-Garcia E (2015) Dairy consumption and risk of frailty in older adults: a prospective cohort study. J Am Geriatr Soc 63(9):1852–1860PubMedCrossRef
31.
Radavelli-Bagatini S, Zhu K, Lewis JR, Dhaliwal SS, Prince RL (2013) Association of dairy intake with body composition and physical function in older community-dwelling women. J Acad Nutr Diet 113(12):1669–1674PubMedCrossRef
32.
33.
Shardell M, Hicks GE, Miller RR, Kritchevsky S, Andersen D, Bandinelli S, Cherubini A, Ferrucci L (2009) Association of low vitamin D levels with the frailty syndrome in men and women. J Gerontol A Biol Sci Med Sci 64(1):69–75PubMedCrossRef
34.
Wang H, Livingston KA, Fox CS, Meigs JB, Jacques PF (2013) Yogurt consumption is associated with better diet quality and metabolic profile in American men and women. Nutr Res 33(1):18–26PubMedCrossRef
35.
Mistura L, D’Addezio L, Sette S, Piccinelli R, Turrini A (2016) Diet quality of Italian yogurt consumers: an application of the probability of adequate nutrient intake score (PANDiet). Int J Food Sci Nutr 67(3):232–238PubMedCrossRef
36.
Parvaneh K, Jamaluddin R, Karimi G, Erfani R (2014) Effect of probiotics supplementation on bone mineral content and bone mass density. ScientificWorldJournal 22:595962
37.
Parvaneh K, Ebrahimi M, Sabran MR, Karimi G, Hwei AN, Abdul-Majeed S, Ahmad Z, Ibrahim Z, Jamaluddin R (2015) Probiotics (Bifidobacterium longum) increase bone mass density and upregulate Sparc and Bmp-2 genes in rats with bone loss resulting from ovariectomy. Biomed Res Int. doi:10.​1155/​2015/​897639 PubMedPubMedCentral
38.
Korhonen H, Pihlanto A (2006) Bioactive peptides: production and functionality. Int Dairy J 16(9):945–960CrossRef
39.
40.
Darling AL, Millward DJ, Torgerson DJ, Hewitt CE, Lanham-New SA (2009) Dietary protein and bone health: a systematic review and meta-analysis. Am J Clin Nutr 90(6):1674–1692PubMedCrossRef
41.
Narva M, Collin M, Lamberg-Allardt C, Kärkkäinen M, Poussa T, Vapaatalo H, Korpela R (2004) Effects of long-term intervention with Lactobacillus helveticus-fermented milk on bone mineral density and bone mineral content in growing rats. Ann Nutr Metab 48(4):228–234PubMedCrossRef
42.
Tu MY, Chen HL, Tung YT, Kao CC, Hu FC, Chen CM (2015) Short-term effects of kefir-fermented milk consumption on bone mineral density and bone metabolism in a randomized clinical trial of osteoporotic patients. PLoS One 10(12):e0144231PubMedPubMedCentralCrossRef
43.
Gilbert JA, Bendsen NT, Tremblay A, Astrup A (2011) Effect of proteins from different sources on body composition. Nutr Metab Cardiovasc Dis 21:B16–B31PubMedCrossRef
44.
Moreno LA, Bel-Serrat S, Santaliestra-Pasías A, Bueno G (2015) Dairy products, yogurt consumption, and cardiometabolic risk in children and adolescents. Nutr Rev 73(suppl 1):8–14PubMedCrossRef
45.
Steves CJ, Bird S, Williams FM, Spector TD (2016) The microbiome and musculoskeletal conditions of aging: a review of evidence for impact and potential therapeutics. J Bone Miner Res 1 31(2):261–269CrossRef
46.
Stanhope KL (2016) Sugar consumption, metabolic disease and obesity: the state of the controversy. Crit Rev Clin Lab Sci 53(1):52–67PubMedCrossRef
47.
United States Department of Agriculture (USDA) (2016) National Nutrient Database for Standard Reference Release 8. Yogurt, fruit, low fat, 9 grams protein per 8 ounce, Basic Report 01120. Accessed 4th July 2016
48.
United States Department of Agriculture (USDA) (2016) National Nutrient Database for Standard Reference Release 8. Yogurt, Greek, plain, low fat, Basic Report 01287. Accessed 4th July 2016
49.
50.
Rozenberg S, Body JJ, Bruyère O et al (2016) Effects of dairy products consumption on health: benefits and beliefs—a commentary from the Belgian Bone Club and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases. Calcif Tissue Int 98(1):1–7PubMedCrossRef
51.
Teucher B, Dainty JR, Spinks CA et al (2008) Sodium and bone health: impact of moderately high and low salt intakes on calcium metabolism in postmenopausal women. J Bone Miner Res 23(9):1477–1485PubMedCrossRef
52.
Bonjour JP, Benoit V, Rousseau B, Souberbielle JC (2012) Consumption of vitamin D-and calcium-fortified soft white cheese lowers the biochemical marker of bone resorption TRAP 5b in postmenopausal women at moderate risk of osteoporosis fracture. J Nutr 142(4):698–703PubMedCrossRef
Metadata
Title
Greater yogurt consumption is associated with increased bone mineral density and physical function in older adults
Authors
E. Laird
A. M. Molloy
H. McNulty
M. Ward
K. McCarroll
L. Hoey
C. F. Hughes
C. Cunningham
J. J. Strain
M. C. Casey
Publication date
01-08-2017
Publisher
Springer London
Published in
Osteoporosis International / Issue 8/2017
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-017-4049-5

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