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Osteoporosis International
Published in: Osteoporosis International 7/2017

01-07-2017 | Original Article

Bone mineral density among Korean females aged 20–50 years: influence of age at menarche (The Korea National Health and Nutrition Examination Survey 2008–2011)

Authors: H. K. Chang, D.-G. Chang, J.-P. Myong, J.-H. Kim, S.-J. Lee, Y. S. Lee, H.-N. Lee, K. H. Lee, D. C. Park, C. J. Kim, S. Y. Hur, J. S. Park, T. C. Park

Published in: Osteoporosis International | Issue 7/2017

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Abstract

Summary

To evaluate a possible correlation between bone mineral density (BMD) and age at menarche, the present study used the BMD dataset of the Korea National Health and Nutrition Examination Survey IV-V (KNHANES IV-V). Age at menarche had a small but significant association with BMD of the lumbar spine in premenopausal Korean females, aged 20–50 years.

Introduction

To investigate any correlation between bone mineral density (BMD) and age at menarche in Korean females using data from the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHANES IV–V; 2008–2011).

Methods

In total, 37,753 individuals participated in health examination surveys between 2008 and 2011. A total of 5032 premenopausal females aged 20–50 years were eligible. Age, height, weight, and age at menarche were assessed.

Results

Results from the univariate linear regression and analysis of covariance (ANCOVA) indicated that age (per 1 year), height (per 1 cm), weight (per 1 kg), exercise (per 1 day/week), familial osteoporosis history (yes), parity (n = 0 to ≥4), and menarche age distribution were associated with BMD of the total femur, femur neck, and lumbar spine. After stratifying the bone area and adjusting for age, parity, alcohol intake, smoking, exercise, and familial osteoporosis history, no effect was seen for the total femur or femur neck. Age at menarche 16~17 and ≥18 years groups were associated with BMD of the lumbar spine only.

Conclusions

Age at menarche had a small but significant association with BMD of the lumbar spine in premenopausal Korean females, aged 20–50 years. Females with late menarche may achieve lower peak bone mass at some skeletal sites, which may put them at greater risk for osteoporosis in later life.
Literature
1.
World Health Organization (2003) Prevention and management of osteoporosis. World Health Organ Tech Rep Ser 921:1–164
2.
Zhang Y, Felson DT, Ellison RC, Kreger BE, Schatzkin A, Dorgan JF, Cupples LA, Levy D, Kiel DP (2001) Bone mass and the risk of colon cancer among postmenopausal women: the Framingham study. Am J Epidemiol 153(1):31–37CrossRefPubMed
3.
Cummings SR, Black DM, Nevitt MC, Browner W, Cauley J, Ensrud K, Genant HK, Palermo L, Scott J, Vogt TM (1993) Bone density at various sites for prediction of hip fractures. The study of osteoporotic fractures research group. Lancet 341(8837):72–75CrossRefPubMed
4.
Varenna M, Binelli L, Zucchi F, Ghiringhelli D, Gallazzi M, Sinigaglia L (1999) Prevalence of osteoporosis by educational level in a cohort of postmenopausal women. Osteoporos Int 9(3):236–241CrossRefPubMed
5.
Tuppurainen M, Kroger H, Saarikoski S, Honkanen R, Alhava E (1995) The effect of gynecological risk factors on lumbar and femoral bone mineral density in peri- and postmenopausal women. Maturitas 21(2):137–145CrossRefPubMed
6.
Sioka C, Fotopoulos A, Georgiou A, Xourgia X, Papadopoulos A, Kalef-Ezra JA (2010) Age at menarche, age at menopause and duration of fertility as risk factors for osteoporosis. Climacteric 13(1):63–71CrossRefPubMed
7.
Ito M, Yamada M, Hayashi K, Ohki M, Uetani M, Nakamura T (1995) Relation of early menarche to high bone mineral density. Calcif Tissue Int 57(1):11–14CrossRefPubMed
8.
Hagemans ML, van der Schouw YT, de Kleijn MJ, van Staveren WA, Pop VJ, Leusink GL, Grobbee DE (2004) Indicators for the total duration of premenopausal endogenous estrogen exposure in relation to BMD. Hum Reprod 19(9):2163–2169CrossRefPubMed
9.
Gerdhem P, Obrant KJ (2004) Bone mineral density in old age: the influence of age at menarche and menopause. J Bone Miner Metab 22(4):372–375CrossRefPubMed
10.
11.
Myong JP, Kim HR, Choi SE, Koo JW (2013) Dose-related effect of urinary cotinine levels on bone mineral density among Korean females. Osteoporos Int 24(4):1339–1346CrossRefPubMed
12.
13.
Seeman E, Duan Y, Fong C, Edmonds J (2001) Fracture site-specific deficits in bone size and volumetric density in men with spine or hip fractures. J Bone Miner Res 16(1):120–127CrossRefPubMed
14.
15.
Cummings SR, Browner WS, Bauer D, Stone K, Ensrud K, Jamal S, Ettinger B (1998) Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of osteoporotic fractures research group. N Engl J Med 339(11):733–738CrossRefPubMed
16.
Turner RT, Riggs BL, Spelsberg TC (1994) Skeletal effects of estrogen. Endocr Rev 15(3):275–300PubMed
17.
Mosselman S, Polman J, Dijkema R (1996) ER beta: identification and characterization of a novel human estrogen receptor. FEBS Lett 392(1):49–53CrossRefPubMed
18.
Oreffo RO, Kusec V, Virdi AS, Flanagan AM, Grano M, Zambonin-Zallone A, Triffitt JT (1999) Expression of estrogen receptor-alpha in cells of the osteoclastic lineage. Histochem Cell Biol 111(2):125–133CrossRefPubMed
19.
Kusec V, Virdi AS, Prince R, Triffitt JT (1998) Localization of estrogen receptor-alpha in human and rabbit skeletal tissues. J Clin Endocrinol Metab 83(7):2421–2428PubMed
20.
Bord S, Horner A, Beavan S, Compston J (2001) Estrogen receptors alpha and beta are differentially expressed in developing human bone. J Clin Endocrinol Metab 86(5):2309–2314PubMed
21.
Silman AJ (2003) Risk factors for Colles’ fracture in men and women: results from the European prospective osteoporosis study. Osteoporos Int 14(3):213–218CrossRefPubMed
22.
Dennison EM, Hindmarsh PC, Kellingray S, Fall CH, Cooper C (2003) Growth hormone predicts bone density in elderly women. Bone 32(4):434–440CrossRefPubMed
23.
Sambrook P, Kelly P, Eisman J (1993) Bone mass and ageing. Baillieres Clin Rheumatol 7(3):445–457CrossRefPubMed
24.
Bonjour JP, Theintz G, Buchs B, Slosman D, Rizzoli R (1991) Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocrinol Metab 73(3):555–563CrossRefPubMed
25.
26.
Danielsen CC, Mosekilde L, Svenstrup B (1993) Cortical bone mass, composition, and mechanical properties in female rats in relation to age, long-term ovariectomy, and estrogen substitution. Calcif Tissue Int 52(1):26–33CrossRefPubMed
27.
Mizuno K, Suzuki A, Ino Y, Asada Y, Kikkawa F, Tomoda Y (1995) Postmenopausal bone loss in Japanese women. Int J Gynaecol Obstet 50(1):33–39CrossRefPubMed
28.
Ho SC, Chen YM, Woo JL (2005) Educational level and osteoporosis risk in postmenopausal Chinese women. Am J Epidemiol 161(7):680–690CrossRefPubMed
29.
Waugh EJ, Lam MA, Hawker GA, McGowan J, Papaioannou A, Cheung AM, Hodsman AB, Leslie WD, Siminoski K, Jamal SA (2009) Risk factors for low bone mass in healthy 40-60 year old women: a systematic review of the literature. Osteoporos Int 20(1):1–21CrossRefPubMed
30.
Parazzini F, Tavani A, Ricci E, La Vecchia C (1996) Menstrual and reproductive factors and hip fractures in post menopausal women. Maturitas 24(3):191–196CrossRefPubMed
31.
Hamed HM, Purdie DW, Steel SA, Howey S (1992) The relation between bone mineral density and early pregnancy loss. Br J Obstet Gynaecol 99(12):946–949CrossRefPubMed
32.
DeCherney A (1996) Bone-sparing properties of oral contraceptives. Am J Obstet Gynecol 174(1 Pt 1):15–20CrossRefPubMed
33.
Kroger H, Tuppurainen M, Honkanen R, Alhava E, Saarikoski S (1994) Bone mineral density and risk factors for osteoporosis—a population-based study of 1600 perimenopausal women. Calcif Tissue Int 55(1):1–7CrossRefPubMed
Metadata
Title
Bone mineral density among Korean females aged 20–50 years: influence of age at menarche (The Korea National Health and Nutrition Examination Survey 2008–2011)
Authors
H. K. Chang
D.-G. Chang
J.-P. Myong
J.-H. Kim
S.-J. Lee
Y. S. Lee
H.-N. Lee
K. H. Lee
D. C. Park
C. J. Kim
S. Y. Hur
J. S. Park
T. C. Park
Publication date
01-07-2017
Publisher
Springer London
Published in
Osteoporosis International / Issue 7/2017
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-017-3997-0

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