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Osteoporosis International
Published in: Osteoporosis International 5/2016

01-05-2016 | Original Article

Usefulness of daily teriparatide treatment in elderly patients over 80 years of age

Authors: R. Niimi, T. Kono, A. Nishihara, M. Hasegawa, A. Matsumine, T. Kono, A. Sudo

Published in: Osteoporosis International | Issue 5/2016

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Abstract

Summary

The percent and absolute lumbar spine and femoral neck bone mineral densities and procollagen type I N-terminal propeptide (PINP) and urinary N-telopeptide level increases noted after teriparatide 20 μg/day treatment for 24 months were similar in the older (age ≥ 80 years) and younger (age < 80 years) subgroups.

Introduction

Many individuals are living into their eighth and ninth decades, but little is known about the efficacy of osteoporosis medication for this population. We retrospectively compared usefulness of daily teriparatide therapy in osteoporosis patients ≥80 and <80 years to detect possible age-related differences.

Methods

We analyzed 628 osteoporosis patients treated with teriparatide 20 μg/day for 24 months. The primary efficacy measures were changes in lumbar spine (LS) and femoral neck (FN) bone mineral density (BMD) over 24 months. Changes in serum procollagen type I N-terminal propeptide levels and urinary N-telopeptide (uNTX) excretion were also measured. Patients were divided into age subgroups (older, ≥80 years; younger, <80 years) for BMD and bone turnover marker comparison.

Results

In the older subgroup, the percent LS BMD significantly increased by 14.6 ± 10.4 % (mean ± SD) and FN BMD significantly increased by 4.5 ± 10.7 % at 24 months. In the younger subgroup, the percent LS BMD significantly increased by 12.2 ± 8.5 % and FN BMD significantly increased by 2.9 ± 8.3 % at 24 months. In the older subgroup, the mean absolute LS BMD change was 0.111 ± 0.071 g/cm2 and FN BMD change was 0.019 ± 0.043 g/cm2. In the younger subgroup, the mean absolute LS BMD change was 0.098 ± 0.065 g/cm2 and FN BMD change was 0.016 ± 0.045 g/cm2. The percent and absolute BMD increases in LS and FN and changes in PINP and uNTX were similar between the subgroups.

Conclusions

The usefulness of daily teriparatide treatment is not age dependent.
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Metadata
Title
Usefulness of daily teriparatide treatment in elderly patients over 80 years of age
Authors
R. Niimi
T. Kono
A. Nishihara
M. Hasegawa
A. Matsumine
T. Kono
A. Sudo
Publication date
01-05-2016
Publisher
Springer London
Published in
Osteoporosis International / Issue 5/2016
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-015-3479-1

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