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Osteoporosis International
Published in: Osteoporosis International 5/2016

01-05-2016 | Letter

Multiple clinical vertebral fractures following denosumab discontinuation

Authors: A. D. Anastasilakis, P. Makras

Published in: Osteoporosis International | Issue 5/2016

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Excerpt

We read with great interest the cases reports of spontaneous vertebral fractures after denosumab discontinuation by Aubry-Rozier et al. [1]. The authors hypothesized that the cause might be the severe rebound effect on bone turnover observed after denosumab discontinuation. …
Literature
1.
Aubry-Rozier B, Gonzalez-Rodriguez E, Stoll D, Lamy O (2015) Severe spontaneous vertebral fractures after denosumab discontinuation: three case reports. Osteoporos Int
2.
Brown JP, Roux C, Törring O et al (2013) Discontinuation of denosumab and associated fracture incidence: analysis from the Fracture Reduction Evaluation of Denosumab in Osteoporosis Every 6 Months (FREEDOM) trial. J Bone Miner Res 28:746–752CrossRefPubMedPubMedCentral
3.
Bone HG, Brandi ML, Brown JP, Chapurlat R, Cummings SR, Czerwinski E, Fahrleitner-Pammer A, Kendler DL, Lippuner K, Reginster J-Y, Roux C, Vittinghoff E, Daizadeh NS, Wang A, Dakin P, Wagman, Papapoulos S. Ten years of denosumab treatment in postmenopausal women with osteoporosis: results from the FREEDOM extension trial. Annual meeting of the American Society for Bone and Mineral Research (ASBMR), October 9–12, 2015, Seattle, USA
Metadata
Title
Multiple clinical vertebral fractures following denosumab discontinuation
Authors
A. D. Anastasilakis
P. Makras
Publication date
01-05-2016
Publisher
Springer London
Published in
Osteoporosis International / Issue 5/2016
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-015-3459-5

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