Skip to main content
Top
Published in: Osteoporosis International 8/2014

01-08-2014 | Case Report

Stress fracture of the ulna associated with bisphosphonate therapy and use of walking aid

Authors: C. S. H. Grace, K. W. B. Kelvin, C. T. Wei, T. B. Yeow

Published in: Osteoporosis International | Issue 8/2014

Login to get access

Abstract

We report a case of a stress fracture of the ulna secondary to long-term bisphosphonate therapy and walking cane. Physicians need to have a high index of suspicion of stress fractures occurring in patients complaining of chronic upper limb pain if they are on bisphosphonate therapy and are using walking aids. Stress fractures of the upper extremities are rare and are usually associated with athletes; however, a few recent case reports have shown an association between stress fractures of the upper extremities and the use of walking aids. The association between increased incidence of upper extremity stress fractures and the use of both bisphosphonates and walking aids in patients has not been well studied, with only one previously reported case. Here, we report a case of a complete stress fracture of the ulna in a 77-year-old female, premorbidly ambulant with walking cane, on long-term bisphosphonates without any pre-existing medical conditions which could result in secondary causes of bone loss. Investigations did not reveal any causes of pathological fracture. This fracture is attributed to the use of long-term bisphosphonate therapy in conjunction with the use of a walking cane. This case highlights the importance of entertaining the possibility of such fractures occurring in any patient who is on bisphosphonate therapy presenting with stress fractures of the upper extremity.
Literature
1.
go back to reference Kanis JA (2007) WHO Technical Report, University of Sheffield, UK: 66 Kanis JA (2007) WHO Technical Report, University of Sheffield, UK: 66
2.
go back to reference Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. OsteoporosInt 17:1726CrossRef Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. OsteoporosInt 17:1726CrossRef
3.
go back to reference Burden of Musculoskeletal Diseases in the United States: Prevalence, Societal and Economic Cost. Rosemont, IL, American Academy of Orthopaedic Surgeons. February 2008 Burden of Musculoskeletal Diseases in the United States: Prevalence, Societal and Economic Cost. Rosemont, IL, American Academy of Orthopaedic Surgeons. February 2008
4.
go back to reference Cummings SR, Black DM, Thompson DE et al (1998) Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. JAMA 280:2077–2082PubMedCrossRef Cummings SR, Black DM, Thompson DE et al (1998) Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. JAMA 280:2077–2082PubMedCrossRef
5.
go back to reference Black DM, Schwartz AV, Ensrud KE et al (2006) Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial. JAMA 296:2927–2938PubMedCrossRef Black DM, Schwartz AV, Ensrud KE et al (2006) Effects of continuing or stopping alendronate after 5 years of treatment: the Fracture Intervention Trial Long-term Extension (FLEX): a randomized trial. JAMA 296:2927–2938PubMedCrossRef
6.
go back to reference Meta-analyses of therapies for postmenopausal osteoporosis. II. Meta-analysis of alendronate for the treatment of postmenopausal women. Cranney A, Wells G, Willan A, Griffith L, Zytaruk N, Robinson V, Black D, Adachi J, Shea B, Tugwell P, Guyatt G, Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group. EndocrRev. 2002;23(4):508. Meta-analyses of therapies for postmenopausal osteoporosis. II. Meta-analysis of alendronate for the treatment of postmenopausal women. Cranney A, Wells G, Willan A, Griffith L, Zytaruk N, Robinson V, Black D, Adachi J, Shea B, Tugwell P, Guyatt G, Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group. EndocrRev. 2002;23(4):508.
7.
go back to reference Girgis CM, Sher D, Seibel MJ (2010) Atypical femoral fractures and bisphosphonate use. N Engl J Med 362:1848–1849PubMedCrossRef Girgis CM, Sher D, Seibel MJ (2010) Atypical femoral fractures and bisphosphonate use. N Engl J Med 362:1848–1849PubMedCrossRef
8.
go back to reference Visekruna M, Wilson D, McKiernan FE (2008) Severely suppressed bone turnover and atypical skeletal fragility. J Clin Endocrinol Metab 93:2948–2952PubMedCrossRef Visekruna M, Wilson D, McKiernan FE (2008) Severely suppressed bone turnover and atypical skeletal fragility. J Clin Endocrinol Metab 93:2948–2952PubMedCrossRef
9.
go back to reference Shane E (2010) Evolving data about subtrochanteric fractures and bisphosphonates. N Engl J Med 362:1825PubMedCrossRef Shane E (2010) Evolving data about subtrochanteric fractures and bisphosphonates. N Engl J Med 362:1825PubMedCrossRef
10.
go back to reference Shane E, Burr D, Abrahamsen B, et al. Atypical subtrochanteric and diaphyseal femoral fractures: Second report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 2013 Shane E, Burr D, Abrahamsen B, et al. Atypical subtrochanteric and diaphyseal femoral fractures: Second report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 2013
11.
go back to reference Giusti A, Neveen AT H, Papapoulos SE (2010) Atypical fractures of the femur and bisphosphonate therapy: a systematic review of case/case series studies. Bone 47(2):169–180PubMedCrossRef Giusti A, Neveen AT H, Papapoulos SE (2010) Atypical fractures of the femur and bisphosphonate therapy: a systematic review of case/case series studies. Bone 47(2):169–180PubMedCrossRef
12.
go back to reference Giusti A, Hamdy NAT, Dekkers OM, Ramautar SR, Dijkstra S, Socrates E, Papapoulos SE (2011) Atypical fractures and bisphosphonate therapy: a cohort study of patients with femoral fracture with radiographic adjudication of fracture site and features. Bone 48(5):966–971PubMedCrossRef Giusti A, Hamdy NAT, Dekkers OM, Ramautar SR, Dijkstra S, Socrates E, Papapoulos SE (2011) Atypical fractures and bisphosphonate therapy: a cohort study of patients with femoral fracture with radiographic adjudication of fracture site and features. Bone 48(5):966–971PubMedCrossRef
13.
go back to reference Yavropoulou MP, Giusti A, Ramautar SR, Dijkstra S, Hamdy NAT, Papapoulos SE (2012) "Low energy fractures of the humeral shaft and bisphosphonate use.". J Bone Miner Res 27(6):1425–1431PubMedCrossRef Yavropoulou MP, Giusti A, Ramautar SR, Dijkstra S, Hamdy NAT, Papapoulos SE (2012) "Low energy fractures of the humeral shaft and bisphosphonate use.". J Bone Miner Res 27(6):1425–1431PubMedCrossRef
14.
go back to reference Iwamoto J, Takeda T (2003) Stress fractures in athletes: review of 196 cases. J Orthop Sci 8(3):273–278PubMedCrossRef Iwamoto J, Takeda T (2003) Stress fractures in athletes: review of 196 cases. J Orthop Sci 8(3):273–278PubMedCrossRef
16.
go back to reference Sørensen L (1992) "Bilateral symmetrical stress fracture of the ulna". Ugeskr Laeger 154(26):1850PubMed Sørensen L (1992) "Bilateral symmetrical stress fracture of the ulna". Ugeskr Laeger 154(26):1850PubMed
17.
go back to reference Venkatanarasimha N, Kamath S, Kambouroglou G, Ostlere SJ (2009) "Proximal ulna stress fracture and stress reaction of the proximal radius associated with the use of crutches: a case report and literature review". J Orthop Traumatol 10(3):155–157PubMedCentralPubMedCrossRef Venkatanarasimha N, Kamath S, Kambouroglou G, Ostlere SJ (2009) "Proximal ulna stress fracture and stress reaction of the proximal radius associated with the use of crutches: a case report and literature review". J Orthop Traumatol 10(3):155–157PubMedCentralPubMedCrossRef
Metadata
Title
Stress fracture of the ulna associated with bisphosphonate therapy and use of walking aid
Authors
C. S. H. Grace
K. W. B. Kelvin
C. T. Wei
T. B. Yeow
Publication date
01-08-2014
Publisher
Springer London
Published in
Osteoporosis International / Issue 8/2014
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-014-2739-9

Other articles of this Issue 8/2014

Osteoporosis International 8/2014 Go to the issue