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01-12-2012 | Position Paper

Treatment failure in osteoporosis

Authors: A. Diez-Perez, J. D. Adachi, D. Agnusdei, J. P. Bilezikian, J. E. Compston, S. R. Cummings, R. Eastell, E. F. Eriksen, J. Gonzalez-Macias, U. A. Liberman, D. A. Wahl, E. Seeman, J. A. Kanis, C. Cooper, for the IOF CSA Inadequate Responders Working Group

Published in: Osteoporosis International | Issue 12/2012

Abstract

Summary

Guidelines concerning the definition of failure of therapies used to reduce the risk of fracture are provided.

Introduction

This study aims to provide guidelines concerning the definition of failure of therapies used to reduce the risk of fracture.

Methods

A working group of the Committee of Scientific Advisors of the International Osteoporosis Foundation was convened to define outcome variables that may assist clinicians in decision making.

Results

In the face of limited evidence, failure of treatment may be inferred when two or more incident fractures have occurred during treatment, when serial measurements of bone remodelling markers are not suppressed by anti-resorptive therapy and where bone mineral density continues to decrease.

Conclusion

The provision of pragmatic criteria to define failure to respond to treatment provides an unmet clinical need and may stimulate research into an important issue.

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Title: Treatment failure in osteoporosis
Authors: A. Diez-Perez
J. D. Adachi
D. Agnusdei
J. P. Bilezikian
J. E. Compston
S. R. Cummings
R. Eastell
E. F. Eriksen
J. Gonzalez-Macias
U. A. Liberman
D. A. Wahl
E. Seeman
J. A. Kanis
C. Cooper
for the IOF CSA Inadequate Responders Working Group
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 12/2012
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-012-2093-8

At a glance: The STEP trials

Springer Medicine

Treatment failure in osteoporosis

Abstract

Summary

Introduction

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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