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01-09-2011 | Position Paper

Interpretation and use of FRAX in clinical practice

Authors: J. A. Kanis, D. Hans, C. Cooper, S. Baim, J. P. Bilezikian, N. Binkley, J. A. Cauley, J. E. Compston, B. Dawson-Hughes, G. El-Hajj Fuleihan, H. Johansson, W. D. Leslie, E. M. Lewiecki, M. Luckey, A. Oden, S. E. Papapoulos, C. Poiana, R. Rizzoli, D. A. Wahl, E. V. McCloskey, Task Force of the FRAX Initiative

Published in: Osteoporosis International | Issue 9/2011

Abstract

Summary

The introduction of the WHO FRAX® algorithms has facilitated the assessment of fracture risk on the basis of fracture probability. Its use in fracture risk prediction has strengths, but also limitations of which the clinician should be aware and are the focus of this review

Introduction

The International Osteoporosis Foundation (IOF) and the International Society for Clinical Densitometry (ISCD) appointed a joint Task Force to develop resource documents in order to make recommendations on how to improve FRAX and better inform clinicians who use FRAX. The Task Force met in November 2010 for 3 days to discuss these topics which form the focus of this review.

Methods

This study reviews the resource documents and joint position statements of ISCD and IOF.

Results

Details on the clinical risk factors currently used in FRAX are provided, and the reasons for the exclusion of others are provided. Recommendations are made for the development of surrogate models where country-specific FRAX models are not available.

Conclusions

The wish list of clinicians for the modulation of FRAX is large, but in many instances, these wishes cannot presently be fulfilled; however, an explanation and understanding of the reasons may be helpful in translating the information provided by FRAX into clinical practice.

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Title: Interpretation and use of FRAX in clinical practice
Authors: J. A. Kanis
D. Hans
C. Cooper
S. Baim
J. P. Bilezikian
N. Binkley
J. A. Cauley
J. E. Compston
B. Dawson-Hughes
G. El-Hajj Fuleihan
H. Johansson
W. D. Leslie
E. M. Lewiecki
M. Luckey
A. Oden
S. E. Papapoulos
C. Poiana
R. Rizzoli
D. A. Wahl
E. V. McCloskey
Task Force of the FRAX Initiative
Publication date: 01-09-2011
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 9/2011
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-011-1713-z

At a glance: The STEP trials

Springer Medicine

Interpretation and use of FRAX in clinical practice

Abstract

Summary

Introduction

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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