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Osteoporosis International
Published in: Osteoporosis International 12/2009

01-12-2009 | Review

Interventions to improve adherence and persistence with osteoporosis medications: a systematic literature review

Authors: T. Gleeson, M. D. Iversen, J. Avorn, A. M. Brookhart, J. N. Katz, E. Losina, F. May, A. R. Patrick, W. H. Shrank, D. H. Solomon

Published in: Osteoporosis International | Issue 12/2009

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Abstract

Summary

Adherence and persistence with osteoporosis medications are poor. We conducted a systematic literature review of interventions to improve adherence and persistence with osteoporosis medications. Seven studies met eligibility requirements and were included in the review. Few interventions were efficacious, and no clear trends regarding successful intervention techniques were identified. However, periodic follow-up interaction between patients and health professionals appeared to be beneficial.

Introduction

Adherence and persistence with pharmacologic therapy for osteoporosis are suboptimal. Our goal was to examine the design and efficacy of published interventions to improve adherence and persistence.

Methods

We searched medical literature databases for English-language papers published between January 1990 and July 2008. We selected papers that described interventions and provided results for control and intervention subjects. We assessed the design and methods of each study, including randomization, blinding, and reporting of drop-outs. We summarized the results and calculated effect sizes for each trial.

Results

Seven studies met eligibility requirements and were included in the review. Five of the seven studies provided adherence data. Of those five studies, three showed a statistically significant (p ≤ 0.05) improvement in adherence by the intervention group, with effect sizes from 0.17 to 0.58. Five of the seven studies provided persistence data. Of those five, one reported statistically significant improvement in persistence by the intervention group, with an effect size of 0.36.

Conclusions

Few interventions were efficacious, and no clear trends regarding successful intervention techniques were identified in this small sample of studies. However, periodic follow-up interaction between patients and health professionals appeared to be beneficial.
Appendix
Available only for authorised users
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Metadata
Title
Interventions to improve adherence and persistence with osteoporosis medications: a systematic literature review
Authors
T. Gleeson
M. D. Iversen
J. Avorn
A. M. Brookhart
J. N. Katz
E. Losina
F. May
A. R. Patrick
W. H. Shrank
D. H. Solomon
Publication date
01-12-2009
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 12/2009
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-009-0976-0

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