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01-06-2009 | Bone Quality Seminars: Ultrastructure

Indentation of bone tissue: a short review

Author: P. K. Zysset

Published in: Osteoporosis International | Issue 6/2009

Excerpt

Bone is a highly hierarchical natural composite material, which mechanical properties are investigated from the physiological elastic behavior up to impact or fatigue damage accumulation responsible for traumatic or stress fractures. Each hierarchical level of organization contributes to the global mechanical response of a bone structure:

The mineralized collagen fibril (MCF, 200 nm)
The lamella (2–7 μm)
The bone structural unit (BSU, 60 μm)
Bone tissue, cortical shell, or trabeculae (100–3,000 μm)
Trabecular bone (TB, mm)
Organ (cm)

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Amprino R (1958) Investigations on some physical properties of bone tissue. Acta Anatomica 34:161–186PubMed

Bembey AK, Oyen ML, Bushby AJ, Boyde A (2006) Viscoelastic properties of bone as a function of hydration state determined by nanoindentation. Philos Mag 86(33–35):5691–5703CrossRef

Blackburn J, Hodgskinson R, Currey JD, Mason JE (1992) Mechanical properties of microcallus in human cancellous bone. J Orthop Res 10(2):237–246PubMedCrossRef

Bonser RH (1995) Longitudinal variation in mechanical competence of bone along avian humerus. J Exp Biol 198:209–212PubMed

Bushby AJ, Ferguson VL, Boyde A (2004) Nanoindentation of bone: Comparison of specimens tested in liquid and embedded in polymethylmetacrylate. J Mater Res 19(1):249–259CrossRef

Carlstroem D (1954) Microhardness measurements on single Haversian systems in bone. Experientia 10:171–172CrossRef

Cheng Y-T, Cheng C-M (2005) Relationships between initial unloading slope, contact depth, and mechanical properties for conical indentation in linear viscoelastic solids. J Mater Res 20(4):1046–1053CrossRef

Chevalier Y, Pahr D, Allmer H, Charlebois M, Zysset P (2007) Validation of a voxel-based FE method for prediction of the uniaxial apparent modulus of human trabecular bone using macroscopic mechanical tests and nanoindentation. J Biomech 40(15):3333–3340PubMedCrossRef

Coats AM, Zioupos P, Aspden RM (2003) Material properties of subchondral bone from patients with osteoporosis or osteoarthritis by microindentation testing and electron probe microanalysis. Calcif Tissue Int 73:66–71PubMedCrossRef

10.

Dall’Ara E, Ohman C, Baleani M, Viceconti M (2007) The effect of tissue condition and applied load on vickers hardness of human trabecular bone. J Biomech 40(14):3267–70PubMedCrossRef

11.

Donnelly E, Baker SP, Boskey AL, Van der Meulen MCH (2006) Effects of surface roughness and maximum load on the mechanical properties of cancellous bone measured by nanoindentation. J Biomed Materi Res, Part A 77A:426–435CrossRef

12.

Evans FG, Lebow M (1951) Regional differences in some of the physical properties of the human femur. J Appl Physiol 3:563–572PubMed

13.

Evans GP, Behiri JC, Currey JD, Bonfield W (1990) Microhardness and Young’s modulus in cortical bone exhibiting a wide range of mineral volume fractions, and in bone analogue. J Mater Sci Mater Med 1:38–43CrossRef

14.

Fischer-Cripps AC (2002) Nanoindentation. Springer Verlag, New York

15.

Guo XE, Goldstein SA (1997) Is trabecular bone tissue different from cortical bone tissue? FORMA 12:185–196

16.

Hengsberger S, Kulik A, Zysset P (2001) A combined atomic force microscopy and nanoindentation technique to investigate the elastic properties of bone structural units. Eur Cell Mater 1:12–7PubMed

17.

Hengsberger S, Boivin G, Zysset Ph (2002a) Morphological and mechanical properties of bone structural units: a two-case study. Int J Jpn Soc Mech Eng 45(4):936–943

18.

Hengsberger S, Kulik A, Zysset Ph (2002b) Nanoindentation discriminates the elastic properties of single human bone lamellae under dry and physiological conditions. Bone

19.

Hengsberger S, Enstroem J, Peyrin F, Zysset Ph (2003) How is the indentation modulus of bone tissue related to its macroscopic elastic response? A validation study. J Biomech 36:1503–1509PubMedCrossRef

20.

Hodgskinson R, Currey JD, Evans GP (1989) Hardness, an indicator of the mechanical competence of cancellous bone. J Orthop Res 7(5):754–758PubMedCrossRef

21.

Hoffler CE, Moore KE, Kozloff K, Zysset PK, Brown MB, Goldstein SA (2000a) Heterogeneity of bone lamellar-level elastic moduli. Bone 26(6):603–609PubMedCrossRef

22.

Hoffler CE, Moore KE, Kozloff K, Zysset PK, Goldstein SA (2000b) Age, gender and bone lamellae elastic moduli. J Orthop Res 18(3):432–437PubMedCrossRef

23.

Hoffler CE, Guo XG, Zysset PK, Goldstein SA (2005) An application of nanoindentation technique to measure bone tissue lamellae properties. J Biomech Eng 127:1046–1053PubMedCrossRef

24.

Lereim P, Goldie IF (1975) Relationship between morphologic features and hardness of the subchondral bone of the medial tibial condyle in the normal state and in osteoarthritis and rheumatoid arthritis. Archiv fuer Orthopdische und Unfallchirurgie 81:1–11

25.

Lereim P, Goldie I, Dahlberg E (1974) Hardness of the subchondral bone of the tibial condyles in the normal state and in osteoarthritis and rheumatoid arthritis. Acta Orthopaedica Scandinavica 45:614–627PubMedCrossRef

26.

Lexer EW (1929) Untersuchungen ueber die Knochenhaerte des Humerus. Zeitschrift fuer Konstitutionslehre 14:227–243

27.

Oliver WC, Pharr GM (2004) Measurement of hardness and elastic modulus by instrumented nanoindentation: advances in understanding and refinements of the methodology. J Mater Res 19(1):3–20CrossRef

28.

Oliver WC, Pharr GM (1992) An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments. J Mater Res 7(6):1564–1583CrossRef

29.

Oyen ML, Bembey AK, Bushby AJ (2008) Poroelastic nanoindentation responses of hydrated bone. J Mater Res 23:1307–1314CrossRef

30.

Ramrakhiani M, Pal D, Murty TS (1979) Micro-indentation hardness studies on human bones. Acta Anatomica 103:358–362PubMed

31.

Rho JY, Pharr GM (1999) Effects of drying on the mechanical properties of bovine femur measured by nanoindentation. J Mater Sci Mater Med 10:485–488PubMedCrossRef

32.

Rho JY, Tsui T, Pharr O (1997) Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation. Biomater 18(29):1325–1330CrossRef

33.

Rho JY, Zioupos P, Currey JD, Pharr GM (1999) Variations in the individual thick lamellar properties within osteons by nanoindentation. Bone 25(3):295–300PubMedCrossRef

34.

Riches PE, Everitt NM, McNally DS (2000) Knoop microhardness anisotropy of the ovine radius. J Biomech 33(12):1551–1557PubMedCrossRef

35.

Riches PE, Everitt NM, Heggie AR, McNally DS (1997) Microhardness anisotropy of lamellar bone. J Biomech 30(10):1059–1061PubMedCrossRef

36.

R. Roessle (1927) Untersuchungen ueber Knochenhaerte. Beitraege zur pathologische Anatomie und zur allgemeine Pathologie, 77

37.

Roschger P, Fratzl P, Eschberger J, Klaushofer K (1998) Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human biopsies. Bone 23(4):319–326PubMedCrossRef

38.

Stea S, Visentin M, Savarino L, Ciapetti G, Donati ME, Moroni A, Caja V, Pizzoferrato A (1995) Microhardness of bone at the interface with ceramic-coated metal implants. J Biomed Materi Res 29:695–699CrossRef

39.

Swadener JG, Pharr GM (2001) Indentation of elastically anisotropic halfspaces by cones and parabolae of revolution. Philos Mag A 81(2):447–466CrossRef

40.

Szilagi M, Kovacs AB, Palfalvi I (1980) Relationship between the ash content and microscopic hardness of swine bones. Acta Veterinaria Academiae Scientiarum Hungaricae 28:455–462

41.

Tang B, Ngan HW (2006) Viscoelastic effects during depth-sensing indentation of cortical bone tissues. Philos Mag 86(33–35):5653–5666CrossRef

42.

Turner CH, Rho J, Takano Y, Tsui TY, Pharr GM (1999) The elastic properties of trabecular and cortical bone tissues are similar: results from two microscopic measurement techniques. J Biomech 32:437–441PubMedCrossRef

43.

Vandamme M, Ulm F-J (2006) Viscoelastic solution for conical indentation. Int J Solids Struct 43:3142–3165CrossRef

44.

Wang X, Sudhaker Rao D, Ajdelsztajn L, Ciarelli TE, Lavernia EJ, Fyhrie DP (2008) Human iliac crest cancellous bone elastic modulus and hardness differ with bone formation rate per bone surface but not by existence of prevalent vertebral fracture. J Biomed Mater Res B Appl Biomater 85(1):68–77PubMed

45.

Weaver JK (1966) The microscopic hardness of bone. J Bone Jt Surg 48-A(2):273–288

46.

Weber M, Roschger P, Fratzl-Zelman N, Schoberl T, Rauch F, Glorieux FH, Fratzl P, Klaushofer K (2006) Pamidronate does not adversely affect bone intrinsic material properties in children with osteogenesis imperfecta. Bone 39(3):616–22PubMedCrossRef

47.

Xu J, Rho JY, Mishra SR, Fan Z (2003) Atomic force microscopy and nanoindentation characterization of human lamellar bone prepared by microtome sectioning and mechanical polishing technique. J Biomed Mater Res A 67(3):719–26PubMedCrossRef

48.

Ziv V, Wigner HD, Weiner S (1996) Microstructure–microhardness relations in parallel-fibered and lamellar bone. Bone 18(5):417–428PubMedCrossRef

49.

Zysset PK, Guo XE, Hoffler CE, Moore K, Goldstein SA. (1999) Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur. J Biomech 32:1005–1012PubMedCrossRef

Title: Indentation of bone tissue: a short review
Author: P. K. Zysset
Publication date: 01-06-2009
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 6/2009
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-0854-9

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