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01-07-2007 | Original Article

The association of bone mineral density measures with incident cardiovascular disease in older adults

Authors: G. N. Farhat, A. B. Newman, K. Sutton-Tyrrell, K. A. Matthews, R. Boudreau, A. V. Schwartz, T. Harris, F. Tylavsky, M. Visser, J. A. Cauley, for the Health ABC study

Published in: Osteoporosis International | Issue 7/2007

Abstract

Summary

The associations of volumetric and areal bone mineral density (BMD) measures with incident cardiovascular disease (CVD) were studied in a biracial cohort of 2,310 older adults. BMD measures were inversely related to CVD in women and white men, independent of age and shared risk factors for osteoporosis and CVD.

Introduction

We investigated the associations of volumetric (vBMD) and areal (aBMD) bone mineral density measures with incident cardiovascular disease (CVD) in older adults enrolled in the Health, Aging, and Body Composition study.

Methods

The incidence of CVD was ascertained in 2,310 well-functioning white and black participants (42% black; 55% women), aged 68–80 years. aBMD measures of the hip were assessed using DXA. Spine trabecular, integral, and cortical vBMD measures were obtained using QCT.

Results

During an average follow-up of 5.4 years, 23% of men and 14% of women had incident CVD. Spine vBMD measures were inversely associated with incident CVD in white men [HR(integral)=1.39, 95% CI 1.03–1.87; HR(cortical)=1.38, 95% CI 1.03–1.84], but not in black men. In women, aBMD measures of the total hip (HR = 1.36, 95% CI 1.03–1.78), femoral neck (HR = 1.44, 95% CI 1.10–1.90), and trochanter (HR = 1.34, 95% CI 1.04–1.72) exhibited significant associations with CVD in blacks, but not in whites. All associations were independent of age and shared risk factors between osteoporosis and CVD, and were not explained by inflammatory cytokines or oxidized LDL.

Conclusion

Our results provide support for an inverse association between BMD and incident CVD. Further research should elucidate possible pathophysiological mechanisms linking osteoporosis and CVD.

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Title: The association of bone mineral density measures with incident cardiovascular disease in older adults
Authors: G. N. Farhat
A. B. Newman
K. Sutton-Tyrrell
K. A. Matthews
R. Boudreau
A. V. Schwartz
T. Harris
F. Tylavsky
M. Visser
J. A. Cauley
for the Health ABC study
Publication date: 01-07-2007
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 7/2007
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-007-0338-8

ACC 2024 Congress

Springer Medicine

The association of bone mineral density measures with incident cardiovascular disease in older adults

Abstract

Summary

Introduction

Methods

Results

Conclusion

ACC 2024 Congress

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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