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01-12-2005 | Original Article

The relationship of vitamin D status to bone mineral density in an Italian population of postmenopausal women

Authors: Nazzarena Malavolta, Loredana Pratelli, Marilena Frigato, Rita Mulè, Maria Lucia Mascia, Saverio Gnudi

Published in: Osteoporosis International | Issue 12/2005

Abstract

Several authors have found a relationship between vitamin D status and bone mineral density (BMD). To our knowledge, no previous studies on this topic have been carried out on the Italian postmenopausal population. We studied this relationship retrospectively in 156 Italian postmenopausal women. We also investigated the relationship between parathyroid hormone (PTH) and BMD. Measurements of BMD were taken at the lumbar spine and upper femur by dual X-ray absorptiometry. Serum 25(OH)D (calcidiol), 1,25(OH)2D (calcitriol), PTH, calcium, phosphorus, creatinine, osteocalcin and urinary calcium and phosphorus were measured according to the current laboratory methods of analysis. We found a positive statistically significant correlation between BMD, both at the spine and hip, and 25(OH)D, and a negative statistically significant correlation between BMD and PTH. No statistically significant correlation was found between BMD and 1,25(OH)2D. Crude logistic regression showed age, 25(OH)D and PTH were significant predictors of low BMD, while 1,25(OH)2D was not. Backward logistic regression showed 25(OH)D was the best predictive model for spine osteoporosis together with age, and on its own it was the best predictive model for femoral neck osteoporosis.

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Title: The relationship of vitamin D status to bone mineral density in an Italian population of postmenopausal women
Authors: Nazzarena Malavolta
Loredana Pratelli
Marilena Frigato
Rita Mulè
Maria Lucia Mascia
Saverio Gnudi
Publication date: 01-12-2005
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 12/2005
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-005-1883-7

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The relationship of vitamin D status to bone mineral density in an Italian population of postmenopausal women

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