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Published in: Osteoporosis International 2/2005

01-03-2005 | Review

The current treatment—a survey of osteoporotic fracture treatment. Osteoporotic spine fractures: the spine surgeon’s perspective

Author: Paul F. Heini

Published in: Osteoporosis International | Special Issue 2/2005

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Abstract

For the spine surgeon the problems of the osteoporotic spine can be a painful simple compression fracture, the persisting instability after a fracture, the silent loss of posture due to progressive collapse of multiple vertebrae, and neurological complications related to an osteoporotic fracture. The use of polymethylmethacrylate (PMMA) for the reinforcement of osteoporotic vertebral bodies has turned out to be extremely efficient. Although the natural course of pain due to vertebral fractures decreases within the first weeks in the majority of patients, there remains a number of them with persistent pain and/or ongoing vertebral collapse. With percutaneous cement injection one can achieve fast and lasting pain reduction in 80% to 93% of patients. With multilevel injections it is possible to address the severe osteoporotic spine as a whole where we can halt the ongoing collapse and preserve posture efficiently. Rectification of lordosis can be achieved in fresh fractures with the kyphoplasty technique and, even more efficiently, with the lordoplasty procedure. Kyphosis correction ranges from 8.5° to 14°, and restoration of vertebral body (VB) height goes up to 90%. When surgical stabilization is required, the combination of PMMA reinforcement and fixation with screws appears the only alternative in order to anchor the implants in the severely osteoporotic bone.
Literature
1.
go back to reference Melton LJ 3rd, Kan SH, Frye MA, et al (1989) Epidemiology of vertebral fractures in women. Am J Epidemiol 129:1000–1011PubMed Melton LJ 3rd, Kan SH, Frye MA, et al (1989) Epidemiology of vertebral fractures in women. Am J Epidemiol 129:1000–1011PubMed
2.
3.
go back to reference Cooper C, Atkinson EJ, O’Fallon WM, Melton LJ 3rd (1992) Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985–1989. J Bone Miner Res 7:221–227PubMed Cooper C, Atkinson EJ, O’Fallon WM, Melton LJ 3rd (1992) Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985–1989. J Bone Miner Res 7:221–227PubMed
4.
go back to reference Riggs BL, Melton LJ 3rd (1995) The worldwide problem of osteoporosis: insights afforded by epidemiology. Bone 17:505S–511S Riggs BL, Melton LJ 3rd (1995) The worldwide problem of osteoporosis: insights afforded by epidemiology. Bone 17:505S–511S
5.
go back to reference EPOS (2002) Incidence of vertebral fracture in Europe: results from the European Prospective Osteoporosis Study (EPOS). J Bone Miner Res 17:716–724PubMed EPOS (2002) Incidence of vertebral fracture in Europe: results from the European Prospective Osteoporosis Study (EPOS). J Bone Miner Res 17:716–724PubMed
7.
go back to reference Lee YL, Yip KM (1996) The osteoporotic spine. Clin Orthop 91–97 Lee YL, Yip KM (1996) The osteoporotic spine. Clin Orthop 91–97
8.
go back to reference Ryan PJ, Blake G, Herd R, Fogelman I (1994) A clinical profile of back pain and disability in patients with spinal osteoporosis. Bone 15:27–30CrossRefPubMed Ryan PJ, Blake G, Herd R, Fogelman I (1994) A clinical profile of back pain and disability in patients with spinal osteoporosis. Bone 15:27–30CrossRefPubMed
9.
go back to reference Cook DJ, Guyatt GH, Adachi JD, et al (1993) Quality of life issues in women with vertebral fractures due to osteoporosis. Arthritis Rheum 36:750–756PubMed Cook DJ, Guyatt GH, Adachi JD, et al (1993) Quality of life issues in women with vertebral fractures due to osteoporosis. Arthritis Rheum 36:750–756PubMed
10.
go back to reference Kado DM, Browner WS, Palermo L, et al (1999) Vertebral fractures and mortality in older women: a prospective study. Study of Osteoporotic Fractures Research Group. Arch Intern Med 159:1215–1220CrossRefPubMed Kado DM, Browner WS, Palermo L, et al (1999) Vertebral fractures and mortality in older women: a prospective study. Study of Osteoporotic Fractures Research Group. Arch Intern Med 159:1215–1220CrossRefPubMed
11.
go back to reference Gold DT (1996) The clinical impact of vertebral fractures: quality of life in women with osteoporosis. Bone 18:185S–189SCrossRefPubMed Gold DT (1996) The clinical impact of vertebral fractures: quality of life in women with osteoporosis. Bone 18:185S–189SCrossRefPubMed
12.
go back to reference Schlaich C, Minne HW, Bruckner T, et al (1998) Reduced pulmonary function in patients with spinal osteoporotic fractures. Osteoporos Int 8:261–267CrossRefPubMed Schlaich C, Minne HW, Bruckner T, et al (1998) Reduced pulmonary function in patients with spinal osteoporotic fractures. Osteoporos Int 8:261–267CrossRefPubMed
13.
go back to reference Center JR, Nguyen TV, Schneider D, et al (1999) Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 353:878–882CrossRefPubMed Center JR, Nguyen TV, Schneider D, et al (1999) Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 353:878–882CrossRefPubMed
15.
go back to reference Lindsay R (2001) Risk of new vertebral fracture in the year following a fracture. JAMA 285:320–323CrossRefPubMed Lindsay R (2001) Risk of new vertebral fracture in the year following a fracture. JAMA 285:320–323CrossRefPubMed
16.
go back to reference Ettinger B, Pressman A, Schein J (1998) Clinic visits and hospital admissions for care of acid-related upper gastrointestinal disorders in women using alendronate for osteoporosis. Am J Manag Care 4:1377–1382PubMed Ettinger B, Pressman A, Schein J (1998) Clinic visits and hospital admissions for care of acid-related upper gastrointestinal disorders in women using alendronate for osteoporosis. Am J Manag Care 4:1377–1382PubMed
17.
go back to reference Watts NB, Harris ST, Genant HK Treatment of painful osteoporotic vertebral fractures with percutaneous vertebroplasty or kyphoplasty. Osteoporos Int 12:429–437 Watts NB, Harris ST, Genant HK Treatment of painful osteoporotic vertebral fractures with percutaneous vertebroplasty or kyphoplasty. Osteoporos Int 12:429–437
18.
go back to reference Einhorn TA (2000) Vertebroplasty: an opportunity to do something really good for patients. Spine 25:1051–1052CrossRefPubMed Einhorn TA (2000) Vertebroplasty: an opportunity to do something really good for patients. Spine 25:1051–1052CrossRefPubMed
19.
go back to reference Barr JD, Barr MS, Lemley TJ, McCann RM (2000) Percutaneous vertebroplasty for pain relief and spinal stabilization. Spine 25:923–928CrossRefPubMed Barr JD, Barr MS, Lemley TJ, McCann RM (2000) Percutaneous vertebroplasty for pain relief and spinal stabilization. Spine 25:923–928CrossRefPubMed
20.
go back to reference Heini PF, Walchli B, Berlemann U (2000) Percutaneous transpedicular vertebroplasty with PMMA: operative technique and early results. A prospective study for the treatment of osteoporotic compression fractures. Eur Spine J 9:445–450CrossRefPubMed Heini PF, Walchli B, Berlemann U (2000) Percutaneous transpedicular vertebroplasty with PMMA: operative technique and early results. A prospective study for the treatment of osteoporotic compression fractures. Eur Spine J 9:445–450CrossRefPubMed
21.
go back to reference Heini P, Orler, R (2004) Vertebroplasty in extreme osteoporosis—experience with multilevel injection. Orthopade (in press) Heini P, Orler, R (2004) Vertebroplasty in extreme osteoporosis—experience with multilevel injection. Orthopade (in press)
22.
go back to reference Perez-Higueras A, Alvarez L, Rossi RE, et al (2002) Percutaneous vertebroplasty: long-term clinical and radiological outcome. Neuroradiology 44:950–954 Perez-Higueras A, Alvarez L, Rossi RE, et al (2002) Percutaneous vertebroplasty: long-term clinical and radiological outcome. Neuroradiology 44:950–954
23.
go back to reference Hodler J, Peck D, Gilula LA (2003) Midterm outcome after vertebroplasty: predictive value of technical and patient-related factors. Radiology 227:662–668PubMed Hodler J, Peck D, Gilula LA (2003) Midterm outcome after vertebroplasty: predictive value of technical and patient-related factors. Radiology 227:662–668PubMed
24.
go back to reference Maynard AS, Jensen ME, Schweickert PA, et al (2000) Value of bone scan imaging in predicting pain relief from percutaneous vertebroplasty in osteoporotic vertebral fractures. AJNR Am J Neuroradiol 21:1807–1812 Maynard AS, Jensen ME, Schweickert PA, et al (2000) Value of bone scan imaging in predicting pain relief from percutaneous vertebroplasty in osteoporotic vertebral fractures. AJNR Am J Neuroradiol 21:1807–1812
25.
go back to reference Kaufmann TJ, Jensen ME, Schweickert PA, et al (2001) Age of fracture and clinical outcomes of percutaneous vertebroplasty. AJNR Am J Neuroradiol 22:1860–1863 Kaufmann TJ, Jensen ME, Schweickert PA, et al (2001) Age of fracture and clinical outcomes of percutaneous vertebroplasty. AJNR Am J Neuroradiol 22:1860–1863
26.
go back to reference Brown DB, Gilula LA, Sehgal M, Shimony JS (2004) Treatment of chronic symptomatic vertebral compression fractures with percutaneous vertebroplasty. AJR Am J Roentgenol 182:319–322 Brown DB, Gilula LA, Sehgal M, Shimony JS (2004) Treatment of chronic symptomatic vertebral compression fractures with percutaneous vertebroplasty. AJR Am J Roentgenol 182:319–322
27.
go back to reference McKiernan F, Jensen R, Faciszewski T (2003) The dynamic mobility of vertebral compression fractures. J Bone Miner Res 18:24–29PubMed McKiernan F, Jensen R, Faciszewski T (2003) The dynamic mobility of vertebral compression fractures. J Bone Miner Res 18:24–29PubMed
28.
go back to reference Jang JS, Kim DY, Lee SH (2003) Efficacy of percutaneous vertebroplasty in the treatment of intravertebral pseudarthrosis associated with noninfected avascular necrosis of the vertebral body. Spine 28:1588–1592CrossRefPubMed Jang JS, Kim DY, Lee SH (2003) Efficacy of percutaneous vertebroplasty in the treatment of intravertebral pseudarthrosis associated with noninfected avascular necrosis of the vertebral body. Spine 28:1588–1592CrossRefPubMed
29.
go back to reference Heini PF, Orler R (2004) Vertebroplasty for severe osteoporosis. Technique and experience with multi-segment injections. Orthopade 33:22–30CrossRefPubMed Heini PF, Orler R (2004) Vertebroplasty for severe osteoporosis. Technique and experience with multi-segment injections. Orthopade 33:22–30CrossRefPubMed
30.
go back to reference Heggeness MH (1993) Spine fracture with neurological deficit in osteoporosis. Osteoporos Int 3:215–221 Heggeness MH (1993) Spine fracture with neurological deficit in osteoporosis. Osteoporos Int 3:215–221
31.
go back to reference Heaney RP (1992) The natural history of vertebral osteoporosis. Is low bone mass an epiphenomenon? Bone 13:S23–26CrossRef Heaney RP (1992) The natural history of vertebral osteoporosis. Is low bone mass an epiphenomenon? Bone 13:S23–26CrossRef
32.
go back to reference Korovessis P, Maraziotis T, Piperos G, Spyropoulos P (1994) Spontaneous burst fracture of the thoracolumbar spine in osteoporosis associated with neurological impairment: a report of seven cases and review of the literature. Eur Spine J 3:286–288PubMed Korovessis P, Maraziotis T, Piperos G, Spyropoulos P (1994) Spontaneous burst fracture of the thoracolumbar spine in osteoporosis associated with neurological impairment: a report of seven cases and review of the literature. Eur Spine J 3:286–288PubMed
33.
go back to reference Nguyen HV, Ludwig S, Gelb D (2003) Osteoporotic vertebral burst fractures with neurologic compromise. J Spinal Disord Tech 16:10–19PubMed Nguyen HV, Ludwig S, Gelb D (2003) Osteoporotic vertebral burst fractures with neurologic compromise. J Spinal Disord Tech 16:10–19PubMed
34.
go back to reference Kim KT, Suk KS, Kim JM, Lee SH (2003) Delayed vertebral collapse with neurological deficits secondary to osteoporosis. Int Orthop 27:65–69PubMed Kim KT, Suk KS, Kim JM, Lee SH (2003) Delayed vertebral collapse with neurological deficits secondary to osteoporosis. Int Orthop 27:65–69PubMed
35.
36.
go back to reference Heini PF (2003) Vertebroplasty: the value of prophylactic augmentation. In: Szpalski M, Gunzburg R (eds) Vertebral osteoporotic compression fractures, pp 211–221 Heini PF (2003) Vertebroplasty: the value of prophylactic augmentation. In: Szpalski M, Gunzburg R (eds) Vertebral osteoporotic compression fractures, pp 211–221
37.
go back to reference Wong W, Riley MA, Garfin S (2002) Vertebroplasty/kyphoplasty. J Womens Imaging 2:117–124 Wong W, Riley MA, Garfin S (2002) Vertebroplasty/kyphoplasty. J Womens Imaging 2:117–124
38.
go back to reference Garfin SR, Yuan HA, Reiley MA (2001) New technologies in the spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures. Spine 26:1511–1515CrossRefPubMed Garfin SR, Yuan HA, Reiley MA (2001) New technologies in the spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures. Spine 26:1511–1515CrossRefPubMed
39.
go back to reference Phillips FM, Todd Wetzel F, Lieberman I, Campbell-Hupp M (2002) An in vivo comparison of the potential for extravertebral cement leak after vertebroplasty and kyphoplasty. Spine 27:2173–2178; discussion 2178–2179CrossRefPubMed Phillips FM, Todd Wetzel F, Lieberman I, Campbell-Hupp M (2002) An in vivo comparison of the potential for extravertebral cement leak after vertebroplasty and kyphoplasty. Spine 27:2173–2178; discussion 2178–2179CrossRefPubMed
40.
go back to reference Heini PF, Orler R (2004) Kyphoplasty for treatment of osteoporotic vertebral fractures. Eur Spine J 3:184–192 Heini PF, Orler R (2004) Kyphoplasty for treatment of osteoporotic vertebral fractures. Eur Spine J 3:184–192
41.
go back to reference Lieberman IH, Dudeney S, Reinhardt MK, Bell G (2001) Initial outcome and efficacy of “kyphoplasty” in the treatment of painful osteoporotic vertebral compression fractures. Spine 26:1631–1638CrossRefPubMed Lieberman IH, Dudeney S, Reinhardt MK, Bell G (2001) Initial outcome and efficacy of “kyphoplasty” in the treatment of painful osteoporotic vertebral compression fractures. Spine 26:1631–1638CrossRefPubMed
42.
go back to reference Bai B, Kummer FJ, Spivak J (2001) Augmentation of anterior vertebral body screw fixation by an injectable, biodegradable calcium phosphate bone substitute. Spine 26:2679–2683CrossRefPubMed Bai B, Kummer FJ, Spivak J (2001) Augmentation of anterior vertebral body screw fixation by an injectable, biodegradable calcium phosphate bone substitute. Spine 26:2679–2683CrossRefPubMed
43.
go back to reference Jang JS, Lee SH, Rhee CH (2002) Polymethylmethacrylate-augmented screw fixation for stabilization in metastatic spinal tumors. Technical note. J Neurosurg 96:131–134 Jang JS, Lee SH, Rhee CH (2002) Polymethylmethacrylate-augmented screw fixation for stabilization in metastatic spinal tumors. Technical note. J Neurosurg 96:131–134
44.
go back to reference Lotz JC, Hu SS, Chiu DF, et al (1997) Carbonated apatite cement augmentation of pedicle screw fixation in the lumbar spine. Spine 22:2716–2723CrossRefPubMed Lotz JC, Hu SS, Chiu DF, et al (1997) Carbonated apatite cement augmentation of pedicle screw fixation in the lumbar spine. Spine 22:2716–2723CrossRefPubMed
45.
go back to reference Wittenberg RH, Lee KS, Shea M, et al (1993) Effect of screw diameter, insertion technique, and bone cement augmentation of pedicular screw fixation strength. Clin Orthop 278–287 Wittenberg RH, Lee KS, Shea M, et al (1993) Effect of screw diameter, insertion technique, and bone cement augmentation of pedicular screw fixation strength. Clin Orthop 278–287
46.
go back to reference Moore DC, Maitra RS, Farjo LA, et al (1997) Restoration of pedicle screw fixation with an in situ setting calcium phosphate cement. Spine 22:1696–1705CrossRefPubMed Moore DC, Maitra RS, Farjo LA, et al (1997) Restoration of pedicle screw fixation with an in situ setting calcium phosphate cement. Spine 22:1696–1705CrossRefPubMed
47.
go back to reference Yerby SA, Toh E, McLain RF (1998) Revision of failed pedicle screws using hydroxyapatite cement. A biomechanical analysis. Spine 23:1657–1661CrossRefPubMed Yerby SA, Toh E, McLain RF (1998) Revision of failed pedicle screws using hydroxyapatite cement. A biomechanical analysis. Spine 23:1657–1661CrossRefPubMed
48.
go back to reference Wuisman PI, Van Dijk M, Staal H, Van Royen BJ (2000) Augmentation of (pedicle) screws with calcium apatite cement in patients with severe progressive osteoporotic spinal deformities: an innovative technique. Eur Spine J 9:528–533CrossRefPubMed Wuisman PI, Van Dijk M, Staal H, Van Royen BJ (2000) Augmentation of (pedicle) screws with calcium apatite cement in patients with severe progressive osteoporotic spinal deformities: an innovative technique. Eur Spine J 9:528–533CrossRefPubMed
Metadata
Title
The current treatment—a survey of osteoporotic fracture treatment. Osteoporotic spine fractures: the spine surgeon’s perspective
Author
Paul F. Heini
Publication date
01-03-2005
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue Special Issue 2/2005
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-004-1723-1

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