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International Urogynecology Journal
Published in: International Urogynecology Journal 10/2016

01-10-2016 | Original Article

Clinical significance of diabetes mellitus on detrusor functionality on stress urinary incontinent women without bladder outlet obstruction

Authors: Yu Seob Shin, Ji Won On, Myung Ki Kim

Published in: International Urogynecology Journal | Issue 10/2016

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Abstract

Introduction and hypothesis

Our aim was to evaluate the effect of diabetes mellitus (DM) on detrusor contractility (DC) in women without bladder outlet obstruction (BOO) by using urodynamic study (UDS).

Methods

We reviewed the clinical records of 863 consecutive women without BOO, each of whom was diagnosed with stress urinary incontinence (SUI) by UDS. Uroflowmetry measurements included maximal flow rate (Qmax), time to Qmax, voided volume, and postvoid residual urine volume (PVR). Data from filling cystometry included the first strong desire to void and the Valsalva leak-point pressure (VLPP). For voiding cystometry data, detrusor pressure at Qmax (Pdet@Qmax) and bladder contractility index (BCI) were analyzed. In the DM group, the level of glycosylated hemoglobin (HbA1c) and DM duration were measured.

Results

After the application of exclusion criteria, complete UDS data of 708 patients were available. The cohort was divided into two groups according to DM status. The DM group comprised 92 (12.9 %) patients, the non-DM group 616 (87.0 %). Mean maximal flow rate and Pdet@Qmax and bladder contractility index were lower in the DM group, in whom mean DM duration was 9.24 ± 7.63 years and mean HbA1c level 7.27 ± 1.43 %. DM duration was significantly correlated with Qmax (−0.309, p = 0.003), Pdet@Qmax (−0.369, p < 0.001), and BCI (−0.409, p < 0.001). Moreover, the HbA1c level was significantly correlated with Qmax (−0.256, p = 0.016), Pdet@Qmax (−0.231, p = 0.026), and BCI (−0.308, p = 0.002).

Conclusions

Our UDS data revealed that DM is associated with impaired DC in women without BOO. Moreover, longer DM duration and poor glycemic control were associated with impaired DC.
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Metadata
Title
Clinical significance of diabetes mellitus on detrusor functionality on stress urinary incontinent women without bladder outlet obstruction
Authors
Yu Seob Shin
Ji Won On
Myung Ki Kim
Publication date
01-10-2016
Publisher
Springer London
Published in
International Urogynecology Journal / Issue 10/2016
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-016-2997-5

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