Skip to main content
Top
Published in: International Urogynecology Journal 8/2014

01-08-2014 | Original Article

Women’s perspective: intra-detrusor botox versus sacral neuromodulation for overactive bladder symptoms after unsuccessful anticholinergic treatment

Authors: Pooja Balchandra, Lynne Rogerson

Published in: International Urogynecology Journal | Issue 8/2014

Login to get access

Abstract

Introduction and hypothesis

Comprehension of women’s perspective and reasons for their choice between intra-detrusor botox (botox) and sacral neuromodulation (SNM) after failed anticholinergic treatment for overactive bladder syndrome (OAB) have not been evaluated and reported in the literature. Our voluntary service evaluation survey aimed to determine reasons behind individual patient choice.

Methods

All women were counseled in detail regarding the two treatment options available after failed anticholinergic treatment as per the hospital trust policy. Once the decision-making process was completed, they were asked to highlight one or more of the 12 questions within the survey that influenced their decision-making process.

Results

Fifty patients, with a mean age of 61.66 years (range 38–82 years) participated in our voluntary survey. Seventy-four per cent chose Botox and 26 % chose SNM. In the botox group 54.05 % disliked the thought of a foreign body in the back with SNM; 45.94 % quoted shorter waiting times and 43.24 % said that the quicker onset of benefit (within 3–5 days) with botox compared with SNM (up to 2 weeks) helped to influence their decision towards botox. In the SNM group 61.53 % were averse to the potential need for botox to be repeated at variable intervals; 46.15 % chose SNM to avoid the risk of urinary retention associated with botox.

Conclusion

The botox group seemed more likely to need quicker results with easy access to the treatment modality, whilst the SNM group seemed keener to focus on a more permanent option with a known interval for the repeat procedure. The difference in patient choice was found to be statistically significant.
Appendix
Available only for authorised users
Literature
1.
go back to reference Arnold J, McLeod N, Thani-Gasalam R, Rashid P (2012) Overactive bladder syndrome—management and treatment options. Aust Fam Physician 41(11):878–883PubMed Arnold J, McLeod N, Thani-Gasalam R, Rashid P (2012) Overactive bladder syndrome—management and treatment options. Aust Fam Physician 41(11):878–883PubMed
2.
go back to reference Dmochowski R, Chapple C, Nitti VW et al (2010) Efficacy and safety of onabotulinumtoxinA for idiopathic overactive bladder: a double-blind, placebo controlled, randomized, dose ranging trial. J Urol 184(6):2416–2422PubMedCrossRef Dmochowski R, Chapple C, Nitti VW et al (2010) Efficacy and safety of onabotulinumtoxinA for idiopathic overactive bladder: a double-blind, placebo controlled, randomized, dose ranging trial. J Urol 184(6):2416–2422PubMedCrossRef
3.
go back to reference Giarenis I, Cardozo L (2013) Management of refractory overactive bladder. Minerva Ginecol 65(1):41–52PubMed Giarenis I, Cardozo L (2013) Management of refractory overactive bladder. Minerva Ginecol 65(1):41–52PubMed
4.
go back to reference Abrams P, Blaivas JG, Fowler CJ et al (2003) The role of neuromodulation in the management of urinary urge incontinence. BJU Int 91(4):355–359PubMedCrossRef Abrams P, Blaivas JG, Fowler CJ et al (2003) The role of neuromodulation in the management of urinary urge incontinence. BJU Int 91(4):355–359PubMedCrossRef
5.
go back to reference Kantartzis K, Shepherd J (2012) Sacral neuromodulation and intravesical botulinum toxin for refractory overactive bladder. Curr Opin Obstet Gynecol 24(5):331–336PubMedCrossRef Kantartzis K, Shepherd J (2012) Sacral neuromodulation and intravesical botulinum toxin for refractory overactive bladder. Curr Opin Obstet Gynecol 24(5):331–336PubMedCrossRef
6.
7.
go back to reference Chapple C, Sievert KD, MacDiarmid S et al (2013) OnabotulinumtoxinA 100 U significantly improves all idiopathic overactive bladder symptoms and quality of life in patients with overactive bladder and urinary incontinence: a randomised, double-blind, placebo-controlled trial. Eur Urol 64(2):249–256PubMedCrossRef Chapple C, Sievert KD, MacDiarmid S et al (2013) OnabotulinumtoxinA 100 U significantly improves all idiopathic overactive bladder symptoms and quality of life in patients with overactive bladder and urinary incontinence: a randomised, double-blind, placebo-controlled trial. Eur Urol 64(2):249–256PubMedCrossRef
8.
go back to reference Digesu GA, Panayi D, Hendricken C, Camarata M, Fernando R, Khullar V (2011) Women’s perspective of botulinum toxin treatment for overactive bladder symptoms. Int Urogynecol J 22(4):425–431PubMedCrossRef Digesu GA, Panayi D, Hendricken C, Camarata M, Fernando R, Khullar V (2011) Women’s perspective of botulinum toxin treatment for overactive bladder symptoms. Int Urogynecol J 22(4):425–431PubMedCrossRef
9.
go back to reference Kalsi V, Apostolidis A, Gonzales G, Elneil S, Dasgupta P, Fowler C (2008) Early effect on the overactive bladder symptoms following botulinum neurotoxin type A injections for detrusor overactivity. Eur Urol 54(1):181–187PubMedCrossRef Kalsi V, Apostolidis A, Gonzales G, Elneil S, Dasgupta P, Fowler C (2008) Early effect on the overactive bladder symptoms following botulinum neurotoxin type A injections for detrusor overactivity. Eur Urol 54(1):181–187PubMedCrossRef
10.
go back to reference Khan S, Kessler TM, Apostolidis A et al (2009) What a patient with refractory idiopathic detrusor overactivity should know about botulinum neurotoxin type a injection. J Urol 181(4):1773–1778PubMedCrossRef Khan S, Kessler TM, Apostolidis A et al (2009) What a patient with refractory idiopathic detrusor overactivity should know about botulinum neurotoxin type a injection. J Urol 181(4):1773–1778PubMedCrossRef
11.
go back to reference Arlandis S, Castro D, Errando C et al (2011) Cost-effectiveness of sacral neuromodulation compared to botulinum neurotoxin a or continued medical management in refractory overactive bladder. Value Health 14(2):219–228PubMedCrossRef Arlandis S, Castro D, Errando C et al (2011) Cost-effectiveness of sacral neuromodulation compared to botulinum neurotoxin a or continued medical management in refractory overactive bladder. Value Health 14(2):219–228PubMedCrossRef
12.
go back to reference Cameron AP, Anger JT, Madison R, Saigal CS, Clemens JQ; Urologic Diseases in America Project (2013) Battery explantation after sacral neuromodulation in the Medicare population. Neurourol Urodyn 32(3):238–241PubMedCrossRef Cameron AP, Anger JT, Madison R, Saigal CS, Clemens JQ; Urologic Diseases in America Project (2013) Battery explantation after sacral neuromodulation in the Medicare population. Neurourol Urodyn 32(3):238–241PubMedCrossRef
13.
go back to reference Jadav AM, Wadhawan H, Jones GL, Wheldon LW, Radley SC, Brown SR (2013) Does sacral nerve stimulation improve global pelvic function in women? Colorectal Dis 15(7):848–857PubMedCrossRef Jadav AM, Wadhawan H, Jones GL, Wheldon LW, Radley SC, Brown SR (2013) Does sacral nerve stimulation improve global pelvic function in women? Colorectal Dis 15(7):848–857PubMedCrossRef
Metadata
Title
Women’s perspective: intra-detrusor botox versus sacral neuromodulation for overactive bladder symptoms after unsuccessful anticholinergic treatment
Authors
Pooja Balchandra
Lynne Rogerson
Publication date
01-08-2014
Publisher
Springer London
Published in
International Urogynecology Journal / Issue 8/2014
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-014-2360-7

Other articles of this Issue 8/2014

International Urogynecology Journal 8/2014 Go to the issue