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International Urogynecology Journal

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Open Access 01-10-2012 | Original Article

Two-year follow-up of an open-label multicenter study of polyacrylamide hydrogel (Bulkamid®) for female stress and stress-predominant mixed incontinence

Authors: Philip Toozs-Hobson, Waleed Al-Singary, Michelle Fynes, Gunilla Tegerstedt, Gunnar Lose

Published in: International Urogynecology Journal | Issue 10/2012

Abstract

Introduction and hypothesis

Polyacrylamide hydrogel (PAHG, Bulkamid®) is a promising urethral bulking agent. This article presents the 2-year follow-up results of a multicenter study of PAHG injections for treating stress and stress-predominant mixed urinary incontinence.

Methods

Submucosal injection of PAHG was performed in 135 women with urinary incontinence, with subjective and objective assessment of the efficacy and safety 24 months postinjection.

Results

At 24 months, the subjective responder rate was 64 % (a statistically non-significant reduction from 67 % at 12 months). The decreased number of incontinence episodes and urine leakage were maintained compared with the result from the 12-month evaluations, as were objective result rates and quality of life data. No safety issues occurred.

Conclusions

PAHG is an effective and safe treatment option for women with stress-predominant mixed urinary incontinence, with maintained medium-term responder rates.

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Title: Two-year follow-up of an open-label multicenter study of polyacrylamide hydrogel (Bulkamid®) for female stress and stress-predominant mixed incontinence
Authors: Philip Toozs-Hobson
Waleed Al-Singary
Michelle Fynes
Gunilla Tegerstedt
Gunnar Lose
Publication date: 01-10-2012
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 10/2012
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-012-1761-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Two-year follow-up of an open-label multicenter study of polyacrylamide hydrogel (Bulkamid®) for female stress and stress-predominant mixed incontinence

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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