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International Urogynecology Journal

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01-11-2010 | Original Article

Long-term outcome of transurethral injection of hyaluronic acid/dextranomer (NASHA/Dx gel) for the treatment of stress urinary incontinence (SUI)

Authors: Farah Lone, Abdul H. Sultan, Ranee Thakar

Published in: International Urogynecology Journal | Issue 11/2010

Abstract

Introduction and hypothesis

To investigate the long-term safety and efficacy of transurethral injection of NASHA/Dx gel in women suffering from stress urinary incontinence (SUI).

Methods

Women with SUI treated with NASHA/Dx gel via the transurethral Implacer™ device at Mayday University Hospital between November 2002 and December 2003 had long-term outcomes of therapy evaluated.

Results

Eighteen of 21 were followed-up at mean 6.7 years (±SD 0.15). One year after the injection, 11/21 (52.3%) reported improvement. Of the women, 6/21 (28.5%) had a repeat injection and seven (33.3%) women experienced adverse events in the form of periurethral swellings. At 6.7 years, only one of seven women was continent of urine without requiring any further continence procedure, 44.4% were still experiencing SUI symptoms. Nine of 18 (42.8%) had undergone other continence procedures.

Conclusion

Transurethral injection of NASHA/Dx gel in women with SUI is associated with complications and not effective in the long term.

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Title: Long-term outcome of transurethral injection of hyaluronic acid/dextranomer (NASHA/Dx gel) for the treatment of stress urinary incontinence (SUI)
Authors: Farah Lone
Abdul H. Sultan
Ranee Thakar
Publication date: 01-11-2010
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 11/2010
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-010-1211-4

At a glance: The STEP trials

Springer Medicine

Long-term outcome of transurethral injection of hyaluronic acid/dextranomer (NASHA/Dx gel) for the treatment of stress urinary incontinence (SUI)

Abstract

Introduction and hypothesis

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusion

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