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International Urogynecology Journal

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01-08-2011 | Original Article

The effect of solifenacin on urethral sphincter morphology

Authors: Jonathan Duckett, Maya Basu

Published in: International Urogynecology Journal | Issue 8/2011

Abstract

Introduction and hypothesis

The aim of the study was to determine whether a 6-week course of 5 mg of solifenacin succinate used to treat mixed incontinence, produces measurable changes in the appearance of the urethral sphincter.

Methods

Twenty-six women undergoing treatment for mixed incontinence were recruited from a urogynaecology unit after failing to improve with conservative treatments and bladder drill. All underwent dual channel subtracted cystometry, which showed mixed urodynamic stress incontinence and detrusor overactivity. All patients underwent a 3D transperineal ultrasound before solifenacin therapy was started and after 6 weeks of treatment. The urethral length, width and volume of the smooth muscle and total sphincter volume were compared before and after the treatment.

Results

Clinically, 13 reported no improvement in either stress or urge incontinence. Eight women reported improvement in their urgency symptoms but no benefit in their stress leakage. Four women reported resolution of both stress and urge incontinence. One woman reported worsening of her bladder symptoms. There was no significant change in the urethral length (p = 0.27), width (p = 0.50), volume of smooth muscle (p = 0.87) or total sphincter volume (p = 0.60) before and after treatment with solifenacin.

Conclusions

A 6-week course of solifenacin resulted in no measurable changes in the appearance of the urethral sphincter.

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Title: The effect of solifenacin on urethral sphincter morphology
Authors: Jonathan Duckett
Maya Basu
Publication date: 01-08-2011
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 8/2011
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-011-1410-7

At a glance: The STEP trials

Springer Medicine

The effect of solifenacin on urethral sphincter morphology

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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