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International Urogynecology Journal

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01-07-2010 | Original Article

Is the beneficial effect of antimuscarinics related to motor or sensory changes in the bladder?

Authors: Demetri C. Panayi, Paris Tekkis, Ruwan Fernando, Vikram Khullar

Published in: International Urogynecology Journal | Issue 7/2010

Abstract

Introduction and hypothesis

The aim of the study was to assess the sensory and motor effects of antimuscarinic treatment on the bladder in women with overactive bladder, detrusor overactivity demonstrated on urodynamics and a mean bladder wall thickness (BWT) greater than 5 mm.

Methods

Fifty-eight women underwent treatment with antimuscarinics in 12 weeks. Before treatment and at 1, 2, 6 and 12 weeks of treatment, women completed the patient perception of bladder condition (PPBC) single-item global questionnaire, indicated the severity of their urgency on a visual analogue scale (VAS) and underwent transvaginal ultrasound to determine mean bladder wall thickness (BWT).

Results

PPBC and VAS scores for urgency declined throughout the treatment course whereas mean BWT declined during the first 6 weeks of treatment and then reached a plateau after falling to below 5 mm.

Conclusion

The mechanism of action of antimuscarinics appears to be a complex interaction of sensory and motor components.

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Title: Is the beneficial effect of antimuscarinics related to motor or sensory changes in the bladder?
Authors: Demetri C. Panayi
Paris Tekkis
Ruwan Fernando
Vikram Khullar
Publication date: 01-07-2010
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 7/2010
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-010-1123-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Is the beneficial effect of antimuscarinics related to motor or sensory changes in the bladder?

Abstract

Introduction and hypothesis

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusion

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