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International Urogynecology Journal

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Open Access 01-06-2011 | Original Article

Prophylactic vesical instillations with 0.2% chondroitin sulfate may reduce symptoms of acute radiation cystitis in patients undergoing radiotherapy for gynecological malignancies

Authors: Menke H. Hazewinkel, Lukas J. A. Stalpers, Marcel G. Dijkgraaf, Jan-Paul W. R. Roovers

Published in: International Urogynecology Journal | Issue 6/2011

Abstract

Introduction and hypothesis

We studied the feasibility and efficacy of intravesical instillations with 40 ml chondroitin sulfate 0.2% solution to prevent or reduce acute radiation cystitis in women undergoing pelvic radiotherapy.

Methods

In a comparative pilot study in 20 patients, half of the patients received instillations. Instillations' bother was measured with visual analog scores (VAS, 0–10); bladder pain, with VAS; micturition-related quality of life, with the urogenital distress inventory (UDI).

Results

One of the instilled patients discontinued the instillations. The first median “acceptability”-VAS was 0 (range, 0–3); the last median was 1 (range, 0–3). “Bladder pain”-VAS peaked halfway in the treatment among controls (median, 1; range, 0–5) and after treatment in the instilled patients (median, 1; range, 1–3). UDI scores showed over time median follow-up scores at or above median baseline scores in controls and at or below median baseline scores in instilled patients.

Conclusion

Intravesical instillations with chondroitin sulfate 0.2% solution may decrease the bother related to bladder symptoms and are well tolerated.

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Title: Prophylactic vesical instillations with 0.2% chondroitin sulfate may reduce symptoms of acute radiation cystitis in patients undergoing radiotherapy for gynecological malignancies
Authors: Menke H. Hazewinkel
Lukas J. A. Stalpers
Marcel G. Dijkgraaf
Jan-Paul W. R. Roovers
Publication date: 01-06-2011
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 6/2011
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-010-1357-0

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Prophylactic vesical instillations with 0.2% chondroitin sulfate may reduce symptoms of acute radiation cystitis in patients undergoing radiotherapy for gynecological malignancies

Abstract

Introduction and hypothesis

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusion

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